2024

最新文章

• Gut bacteria are essential for development of an invasive bark beetle by regulating glucose transport AI翻译
  作者：Liu, Fanghua; Ye, Fangyuan; Yang, Yunwen; Kang, Zhiwei; Liu, Yang; Chen, Wei; Wang, Saige; Kou, Hongru; Kang, Le; Sun, Jianghua
  作者单位：Hebei University; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS
  摘要：Insects and their gut bacteria form a tight and beneficial relationship, especially in utilization of host nutrients. The red turpentine beetle (RTB), a destructive and invasive pine pest, employs mutualistic microbes to facilitate its invasion success. However, the molecular mechanism underlying the utilization of nutrients remains unknown. In this study, we found that gut bacteria are crucial for the utilization of D- glucose, a main carbon source for RTB development. Downstream assays revea...
• Reconstruction of single- cell lineage trajectories and identification of diversity in fates during the epithelial- to- mesenchymal transition AI翻译
  作者：Cheng, Yu - Chen; Zhang, Yun; Tripathi, Shubham; Harshavardhan, B. V.; Jolly, Mohit Kumar; Schiebinger, Geoffrey; Levine, Herbert; Mcdonald, Thomas O.; Michor, Franziska
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS; Yale University; Indian Institute of Science (IISC) - Bangalore; Indian Institute of Science (IISC) - Bangalore; University of British Columbia; Northeastern University; Northeastern University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Exploring the complexity of the epithelial- to- mesenchymal transition (EMT) unveils a diversity of potential cell fates; however, the exact timing and mechanisms by which early cell states diverge into distinct EMT trajectories remain unclear. Studying these EMT trajectories through single- cell RNA sequencing is challenging due to the necessity of sacrificing cells for each measurement. In this study, we employed optimal- transport analysis to reconstruct the past trajectories of different c...
• Significant challenges to the sustainability of the California coast considering climate change AI翻译
  作者：Thorne, Karen M.; Macdonald, Glen M.; Chavez, Francisco P.; Ambrose, Richard F.; Barnard, Patrick L.
  作者单位：United States Department of the Interior; United States Geological Survey; University of California System; University of California Los Angeles; Monterey Bay Aquarium Research Institute; University of California System; University of California Los Angeles; United States Department of the Interior; United States Geological Survey
  摘要：Climate change is an existential threat to the environmental and socioeconomic sustainability of the coastal zone and impacts will be complex and widespread. Evidence from California and across the United States shows that climate change is impacting coastal communities and challenging managers with a plethora of stressors already present. Widespread action could be taken that would sustain California's coastal ecosystems and communities. In this perspective, we highlight the main threat to co...
• Pink noise promotes sooner state transitions during bimanual coordination AI翻译
  作者：Brink, Kolby J.; Kim, Seung Kyeom; Sommerfeld, Joel H.; Amazeen, Polemnia G.; Stergiou, Nikolaos; Likens, Aaron D.
  作者单位：University of Nebraska System; Arizona State University; Arizona State University-Tempe; Aristotle University of Thessaloniki
  摘要：The seemingly straightforward task of tying one's shoes requires a sophisticated interplay of joints, muscles, and neural pathways, posing a formidable challenge for researchers studying the intricacies of coordination. A widely accepted framework for measuring coordinated behavior is the Haken-Kelso-Bunz (HKB) model. However, a significant limitation of this model is its lack of accounting for the diverse variability structures inherent in the coordinated systems it frequently models. Variabi...
• Dynamic spatial representation of self and others' actions in the macaque frontal cortex AI翻译
  作者：Ninomiya, Taihei; Isoda, Masaki
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Institute for Physiological Sciences (NIPS); Graduate University for Advanced Studies - Japan
  摘要：Modulation of neuronal firing rates by the spatial locations of physical objects is a widespread phenomenon in the brain. However, little is known about how neuronal responses to the actions of biological entities are spatially tuned and whether such spatially tuned responses are affected by social contexts. These issues are of key importance for understanding the neural basis of embodied social cognition, such as imitation and perspective- taking. Here, we show that spatial representation of ...
• Resolving the 22q11.2 deletion using CTLR- Seq reveals chromosomal rearrangement mechanisms and individual variance in breakpoints AI翻译
  作者：Zhou, Bo; Purmann, Carolin; Guo, Hanmin; Shin, GiWon; Huang, Yiling; Pattni, Reenal; Meng, Qingxi; Greer, Stephanie U.; Roychowdhury, Tanmoy; Wood, Raegan N.; Ho, Marcus; zu Dohna, Heinrich; Abyzov, Alexej; Hallmayer, Joachim F.; Wong, Wing H.; Ji, Hanlee P.; Urban, Alexander E.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Mayo Clinic; American University of Beirut; Stanford University; Washington University (WUSTL); Yale University
  摘要：We developed a generally applicable method, CRISPR/Cas9- targeted long- read sequencing (CTLR-Seq), to resolve, haplotype- specifically, the large and complex regions in the human genome that had been previously impenetrable to sequencing analysis, such as large segmental duplications (SegDups) and their associated genome rearrangements. CTLR-Seq combines in vitro Cas9- mediated cutting of the genome and pulse- field gel electrophoresis to isolate intact large (i.e., up to 2,000 kb) genomic re...
• Dibutyl phthalate released by solitary female locusts mediates sexual communication at low density AI翻译
  作者：Cui, Weichan; Ge, Jin; Chen, Dafeng; Nie, Xin; Dong, Liushu; Wang, Xianhui; Kang, Le
  作者单位：Chinese Academy of Sciences; Institute of Zoology, CAS; China Agricultural University; Hebei University
  摘要：Sex pheromones play a crucial role in mate location and reproductive success. Insects face challenges in finding mates in low- density environments. The population dynamics of locusts vary greatly, ranging from solitary individuals to high- density swarms, leading to multiple- trait divergence between solitary and gregarious phases. However, differences in sexual communication between solitary and gregarious locusts have not been sufficiently explored. Herein, we found that solitary locusts bu...
• A silicon diode-based optoelectronic interface for bidirectional neural modulation AI翻译
  作者：Fu, Xin; Hu, Zhengwei; Li, Wenjun; Ma, Liang; Chen, Junyu; Liu, Muyang; Liu, Jie; Hu, Shuhan; Wang, Huachun; Huang, Yunxiang; Tang, Guo; Zhang, Bozhen; Cai, Xue; Wang, Yuqi; Li, Lizhu; Ma, Jian; Shi, Song - Hai; Yin, Lan; Zhang, Hao; Li, Xiaojian; Sheng, Xing
  作者单位：Tsinghua University; Tsinghua University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Tsinghua University; Tsinghua University; Sun Yat Sen University
  摘要：The development of advanced neural modulation techniques is crucial to neuroscience research and neuroengineering applications. Recently, optical- based, nongenetic modulation approaches have been actively investigated to remotely interrogate the nervous system with high precision. Here, we show that a thin- film, silicon (Si)- based diode device is capable to bidirectionally regulate in vitro and in vivo neural activities upon adjusted illumination. When exposed to high- power and short- puls...
• SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23 (vol 121, e2322974121, 2024) AI翻译
  作者：Segovia, Danilo; Adams, Dexter W.; Hoffman, Nickolas; Tepes, Polona Safaric; Wee, Tse- Luen; Cifani, Paolo; Joshua-Tor, Leemor; Krainer, Adrian R.
• An RNA aptamer exploits exosite- dependent allostery to achieve specific inhibition of coagulation factor IXa AI翻译
  作者：Kolyadko, Vladimir N.; Layzer, Juliana M.; Perry, Kay; Sullenger, Bruce A.; Krishnaswamy, Sriram
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Duke University; United States Department of Energy (DOE); Argonne National Laboratory; Cornell University; University of Pennsylvania
  摘要：Hemostasis relies on a reaction network of serine proteases and their cofactors to form a blood clot. Coagulation factor IXa (protease) plays an essential role in hemostasis as evident from the bleeding disease associated with its absence. RNA aptamers specifically targeting individual coagulation factors have potential as anticoagulants and as probes of the relationship between structure and function. Here, we report X- ray structures of human factor IXa without a ligand bound to the active s...