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作者：Bail, Christopher A.
作者单位：Duke University; Duke University; Duke University
摘要：Generative AI that can produce realistic text, images, and other human-like outputs is currently transforming many different industries. Yet it is not yet known how such tools might influence social science research. I argue Generative AI has the potential to improve survey research, online experiments, automated content analyses, agent-based models, and other techniques commonly used to study human behavior. In the second section of this article, I discuss the many limitations of Generative A...
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作者：Braymer, Joseph J.; Stehling, Oliver; Stuempfig, Martin; Roesser, Ralf; Spantgar, Farah; Blinn, Catharina M.; Muehlenhoff, Ulrich; Pierik, Antonio J.; Lill, Roland
作者单位：Philipps University Marburg; Philipps University Marburg; Federal Institute for Materials Research & Testing
摘要：The biogenesis of iron-sulfur (Fe/S) proteins entails the synthesis and trafficking of Fe/S clusters, followed by their insertion into target apoproteins. In eukaryotes, the multiple steps of biogenesis are accomplished by complex protein machineries in both mitochondria and cytosol. The underlying biochemical pathways have been elucidated over the past decades, yet the mechanisms of cytosolic [2Fe-2S] protein assembly have remained ill-defined. Similarly, the precise site of glutathione (GSH)...
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作者：Emery, Caroline M.; Vijayendran, Krishna G.; Zipser, Marie C.; Sawyer, Allison M.; Niu, Lili; Kim, Jessica J.; Hatton, Charles; Chopra, Rajiv; Oberholzer, Patrick A.; Karpova, Maria B.; MacConaill, Laura E.; Zhang, Jianming; Gray, Nathanael S.; Sellers, William R.; Dummer, Reinhard; Garraway, Levi A.
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作者：Sanchez, Ignacio E.; Galpern, Ezequiel A.; Ferreiro, Diego U.
作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
摘要：We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to the chemical composition of biopolymers and crucially depend on the solvent in which they are embedded. We show that molecular information theory and energy landscape theory allow us to explore the limits that solvents impose on biopolymer existence. We consider 54 solvents, including water, alcohols, hydrocarbons, ...
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作者：Xie, Yu; Yang, Feng; Huang, Junming; He, Yuchen; Zhou, Yi; Qian, Yue; Cai, Weicheng; Zhou, Jie
作者单位：Princeton University; Peking University; University of British Columbia; Chinese Academy of Sciences; Institute of Psychology, CAS
摘要：In this paper, we present findings from four separate studies using different data sources and methods to examine Chinese attitudes toward the United States amid the COVID - 19 pandemic. The empirical results consistently indicate a marked and significant decline in Chinese attitudes toward the US between late 2019 and the end of 2022. Using a quasi - experimental design and granular survey data that exploit daily variations in public opinion, we offer additional evidence that the decline in C...
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作者：Beissinger, Steven R.; Berg, Karl S.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Texas System; University of Texas Rio Grande Valley
摘要：Infanticide and adoption have been attributed to sexual selection, where an individual later reproduces with the parent whose offspring it killed or adopted. While sexually selected infanticide is well known, evidence for sexually selected adoption is anecdotal. We report on both behaviors at 346 nests over 27 y in green - rumped parrotlets ( Forpus passerinus ) in Venezuela. Parrotlets are monogamous with long - term pair bonds, exhibit a strongly male - biased adult sex ratio, and nest in ca...
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作者：Jing, Weiqiang; Wang, Ganyu; Cui, Zhiwei; Li, Xinyuan; Zeng, Shuyan; Jiang, Xin; Li, Wushan; Han, Bo; Xing, Nianzeng; Zhao, Yunxue; Chen, Shouzhen; Shi, Benkang
作者单位：Shandong University; Shandong University; Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong University; Shandong University; Shandong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS
摘要：The immune landscape of bladder cancer progression is not fully understood, and effective therapies are lacking in advanced bladder cancer. Here, we visualized that bladder cancer cells recruited neutrophils by secreting interleukin - 8 (IL - 8); in turn, neutrophils played dual functions in bladder cancer, including hepatocyte growth factor (HGF) release and CCL3 high PD - L1 high super - immunosuppressive subset formation. Mechanistically, c - Fos was identified as the mediator of HGF up - r...
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作者：Knight, David Jonathan; Zhang, Baobao
作者单位：Columbia University; Columbia University; Syracuse University
摘要：This study examines the impact of residential mobility on electoral participation among the poor by matching data from Moving to Opportunity, a US - based multicity housing - mobility experiment, with nationwide individual voter data. Nearly all participants in the experiment were Black and Hispanic families who originally lived in high - poverty public housing developments. Notably, the study finds that receiving a housing voucher to move to a lowpoverty neighborhood decreased adult participa...
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作者：Ma, Tianyi; Rothschild, Jeremy; Halabeya, Faisal; Zilman, Anton; Milstein, Joshua N.
作者单位：University of Toronto; University of Toronto; University Toronto Mississauga
摘要：Multispecies bacterial populations often inhabit confined and densely packed encommunity. However, the role of mechanical interactions in shaping the ecology is still poorly understood. Here, we study a model system consisting of two populations of nonmotile Escherichia coli bacteria competing within open, monolayer microchannels. The competitive dynamics is observed to be biphasic: After seeding, either one strain rapidly fixates or both strains orient into spatially stratified, stable commun...
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作者：Chen, Jingting; Stephan, Till; Gaedke, Felix; Liu, Tianyan; Li, Yiyan; Schauss, Astrid; Chen, Peng; Wulff, Veronika; Jakobs, Stefan; Juengst, Christian; Chen, Zhixing
作者单位：Peking University; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Cologne; Peking University; University of Gottingen
摘要：Fluorescence labeling of chemically fixed specimens, especially immunolabeling, plays a vital role in superresolution imaging as it offers a convenient way to visualize cellular structures like mitochondria or the distribution of biomolecules with high detail. Despite the development of various distinct probes that enable superresolved stimulated emission depletion (STED) imaging of mitochondria in live cells, most of these membrane - potential - dependent fluorophores cannot be retained well ...
