2024

最新文章

• The IL-17 pathway intertwines with neurotrophin and TLR/IL-1R pathways since its domain shuffling origin AI翻译
  作者：Chen, Shenghui; Fan, Huiping; Ran, Chenrui; Hong, Yun; Feng, Huixiong; Yue, Zirui; Zhang, Hao; Pontarotti, Pierre; Xu, Anlong; Huang, Shengfeng
  作者单位：Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Aix-Marseille Universite; Beijing University of Chinese Medicine
  摘要：The IL- 17 pathway displays remarkably diverse functional modes between different subphyla, classes, and even orders, yet its driving factors remains elusive. Here, we demonstrate that the IL- 17 pathway originated through domain shuffling between a Toll- like receptor (TLR)/IL- 1R pathway and a neurotrophin- RTK (receptor- tyrosine- kinase) pathway (a Trunk- Torso pathway). Unlike other new pathways that evolve independently, the IL- 17 pathway remains intertwined with its donor pathways thro...
• HYPK: A marginally disordered protein sensitive to charge decoration AI翻译
  作者：Firouzbakht, Arash; Haider, Austin; Gaalswyk, Kari; Alaeen, Sepehr; Ghosh, Kingshuk; Gruebele, Martin
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Denver; University of Denver; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Intrinsically disordered proteins (IDPs) that lie close to the empirical boundary separating IDPs and folded proteins in Uversky's charge-hydropathy plot may behave as marginal IDPs and sensitively switch conformation upon changes in environment (temperature, crowding, and charge screening), sequence, or both. In our search for such a marginal IDP, we selected Huntingtin - interacting protein K (HYPK) near that boundary as a candidate; PKI alpha , also near that boundary, has lower secondary s...
• Chaotic neural dynamics facilitate probabilistic computations through sampling AI翻译
  作者：Terada, Yu; Toyoizumi, Taro
  作者单位：RIKEN; University of California System; University of California San Diego; University of Tokyo; University of Tokyo
  摘要：Cortical neurons exhibit highly variable responses over trials and time. Theoretical works posit that this variability arises potentially from chaotic network dynamics of recurrently connected neurons. Here, we demonstrate that chaotic neural dynamics, formed through synaptic learning, allow networks to perform sensory cue integration in a sampling -based implementation. We show that the emergent chaotic dynamics provide neural substrates for generating samples not only of a static variable bu...
• Identifying air quality monitoring deserts in the United States AI翻译
  作者：Roque, Nelson A.; Andrews, Hailey; Santos-Lozada, Alexis R.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Air quality is associated with adverse health outcomes and mortality risk. While most research has focused on the association between air quality estimates and these outcomes, or the place- level characteristics associated with such placements. We classify counties without a monitoring station as air quality monitoring deserts. Using the Environmental Protection Agency's AirData active sites directory, we determine the number and location of monitoring deserts. We then study whether demographi...
• Milestoning estimators of dissipation in systems observed at a coarse resolution AI翻译
  作者：Blom, Kristian; Song, Kevin; Vouga, Etienne; Godec, Aljaz; Makarov, Dmitrii E.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：Many nonequilibrium, active processes are observed at a coarse -grained level, where different microscopic configurations are projected onto the same observable state. Such lumped observables display memory, and in many cases, the irreversible character of the underlying microscopic dynamics becomes blurred, e.g., when the projection hides dissipative cycles. As a result, the observations appear less irreversible, and it is very challenging to infer the degree of broken time -reversal symmetry...
• The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction AI翻译
  作者：Woo, Ju Rang; Bae, Seung-Hyun; Wales, Thomas E.; Engen, John R.; Lee, Jongsoon; Jang, Hyonchol; Park, Sangyoun
  作者单位：National Cancer Center - Korea (NCC); National Cancer Center - Korea (NCC); Northeastern University; Soonchunhyang University; Soongsil University; Soongsil University
  摘要：Serine phosphorylations on insulin receptor substrate 1 (IRS - 1) by diverse kinases aoccur widely during obesity - , stress - , and inflammation - induced conditions in models of insulin resistance and type 2 diabetes. In this study, we define a region within the human IRS - 1, which is directly C - terminal to the PTB domain encompassing numerous serine phosphorylation sites including Ser307 (mouse Ser302) and Ser312 (mouse 307) creating a phosphorylation insulin resistance (PIR) domain. We ...
• The Myc- associated zinc finger protein epigenetically controls expression of interferon-γ-stimulated genes by recruiting STAT1 to chromatin AI翻译
  作者：Xiao, Tiaojiang; Li, Xin; Felsenfeld, Gary
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：The MYC - Associated Zinc Finger Protein (MAZ) plays important roles in chromatin organization and gene transcription regulation. Dysregulated expression of MAZ causes diseases, such as glioblastoma, breast cancer, prostate cancer, and liposarcoma. Previously, it has been reported that MAZ controls the proinflammatory response colitis and colon cancer via STAT3 signaling, suggesting that MAZ is involved in ulating immunity - related pathways. However, the molecular mechanism underlying this re...
• Caenorhabditis elegans telomere- binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA AI翻译
  作者：Padmanaban, Shilpa; Lambacher, Nils J.; Tesmer, Valerie M.; Zhang, Jingjing; Shibuya, Hiroki; Nandakumar, Jayakrishnan
  作者单位：University of Michigan System; University of Michigan; Washington University (WUSTL); University of Gothenburg; RIKEN
  摘要：Protecting chromosome ends from misrecognition as double- stranded (ds) DNA breaks is fundamental to eukaryotic viability. The protein complex shelterin prevents a DNA damage response at mammalian telomeres. Mammalian shelterin proteins TRF1 and TRF2 and their homologs in yeast and protozoa protect telomeric dsDNA. N- terminal homodimerization and C- terminal Myb- domain- mediated dsDNA binding are two structural hallmarks of end protection by TRF homologs. Yet our understanding of how Caenorh...
• Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity, and pigment transfer AI翻译
  作者：Prosperi, Marie- Therese; Giordano, Cecile; Gomez-Duro, Mireia; Hurbain, Ilse; Mace, Anne- Sophie; Raposo, Graca; D'Angelo, Gisela
  作者单位：Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS)
  摘要：Extracellular vesicles (EVs) facilitate the transfer of proteins, lipids, and genetic material between cells and are recognized as an additional mechanism for sustaining intercellular communication. In the epidermis, the communication between melanocytes and keratinocytes is tightly regulated to warrant skin pigmentation. Melanocytes synthesize the melanin pigment in melanosomes that are transported along the dendrites prior to the transfer of melanin pigment to keratinocytes. EVs secreted by ...
• Soil moisture decline in China's monsoon loess critical zone: More a result of land- use conversion than climate change AI翻译
  作者：Wang, Yunqiang; Hu, Wei; Sun, Hui; Zhao, Yali; Zhang, Pingping; Li, Zimin; Zhou, Zixuan; Tong, Yongping; Liu, Shaozhen; Zhou, Jingxiong; Huang, Mingbin; Jia, Xiaoxu; Clothier, Brent; Shao, Ming'an; Zhou, Weijian; An, Zhisheng
  作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Xi'an Jiaotong University; New Zealand Institute for Plant & Food Research Ltd; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Soil & Water Conservation (ISWC), CAS; Ministry of Water Resources; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; New Zealand Institute for Plant & Food Research Ltd; Beijing Normal University
  摘要：Soil moisture (SM) is essential for sustaining services from Earth's critical zone, a thinliving skin spanning from the canopy to groundwater. In the Anthropocene epoch, intensive afforestation has remarkably contributed to global greening and certain service improvements, often at the cost of reduced SM. However, attributing the response of SM in deep soil to such human activities is a great challenge because of the scarcity of long - term observations. Here, we present a 37 y (1985 to 2021) ...