Gut bacteria are essential for development of an invasive bark beetle by regulating glucose transport

• 成果类型: Article
• 署名作者: Liu, Fanghua; Ye, Fangyuan; Yang, Yunwen; Kang, Zhiwei; Liu, Yang; Chen, Wei; Wang, Saige; Kou, Hongru; Kang, Le; Sun, Jianghua
• 署名单位: Hebei University; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9079
• DOI: 10.1073/pnas.2410889121
• 发表日期: 2024-08-13
• 关键词: chain fatty-acids; skeletal-muscle; microbiota; metabolism; GROWTH; cells

摘要

Insects and their gut bacteria form a tight and beneficial relationship, especially in utilization of host nutrients. The red turpentine beetle (RTB), a destructive and invasive pine pest, employs mutualistic microbes to facilitate its invasion success. However, the molecular mechanism underlying the utilization of nutrients remains unknown. In this study, we found that gut bacteria are crucial for the utilization of D- glucose, a main carbon source for RTB development. Downstream assays revealed that gut bacteria- induced gut hypoxia and the secretion of riboflavin are responsible for RTB development by regulating D- glucose transport via the activation of a hypoxia- induced transcription factor 1 (Hif-1 alpha). Further functional investigations confirmed that Hif-1 alpha mediates glucose transport by direct upregulation of two glucose transporters (ST10 and ST27), thereby promoting RTB development. Our findings reveal how gut bacteria regulate the development of RTB, and promote our understanding of the mutualistic relationship of animals and their gut bacteria.