-
作者：Martinez-Vasallo, Carlos; Cole, Benjamin; Perez-Alemany, Jaime; Ortiz-Ramirez, Clara I.; Gallego-Bartolome, Javier; Chory, Joanne; Kay, Steve A.; Nohales, Maria A.
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universitat Politecnica de Valencia; CSIC-UPV - Instituto de Biologia Molecular y Celular de Plantas (IBMCP); University of Southern California; Salk Institute; Howard Hughes Medical Institute; United States Department of Energy (DOE); Joint Genome Institute - JGI; Lawrence Berkeley National Laboratory
摘要：For plants adapted to bright light, a decrease in the amount of light received can be detrimental to their growth and survival. Consequently, in response to shade from surrounding vegetation, they initiate a suite of molecular and morphological changes known as the shade avoidance response through which stems and petioles elongate in search for light. Under sunlight-night cycles, the plant's responsiveness to shade varies across the day, being maximal at dusk time. While a role for the circadi...
-
作者：Aquino-Perez, Cecilia; Safaralizade, Mahira; Podhajecky, Roman; Wang, Hong; Lansky, Zdenek; Grosse, Robert; Macurek, Libor
作者单位：Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; University of Freiburg; Czech Academy of Sciences; Institute of Biotechnology of the Czech Academy of Sciences; University of Freiburg
摘要：Precise segregation of chromosomes during mitosis requires assembly of a bipolar mitotic spindle followed by correct attachment of microtubules to the kinetochores. This highly spatiotemporally organized process is controlled by various mitotic kinases and molecular motors. We have recently shown that Casein Kinase 1 (CK1) promotes timely progression through mitosis by phosphorylating FAM110A leading to its enrichment at spindle poles. However, the mechanism by which FAM110A exerts its functio...
-
作者：Nova, Ian C.; Craig, Jonathan M.; Mazumder, Abhishek; Laszlo, Andrew H.; Derrington, Ian M.; Noakes, Matthew T.; Brinkerhoff, Henry; Yang, Shuya; Vahedian-Movahed, Hanif; Li, Lingting; Zhang, Yu; Bowman, Jasmine L.; Huang, Jesse R.; Mount, Jonathan W.; Ebright, Richard H.; Gundlach, Jens H.
作者单位：University of Washington; University of Washington Seattle; Rutgers University System; Rutgers University New Brunswick; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
摘要：RNA polymerases (RNAPs) carry out the first step in the central dogma of molecular biology by transcribing DNA into RNA. Despite their importance, much about how RNAPs work remains unclear, in part because the small (3.4 Angstrom) and fast (similar to 40 ms/nt) steps during transcription were difficult to resolve. Here, we used high- resolution nanopore tweezers to observe the motion of single Escherichia coli RNAP molecules as it transcribes DNA similar to 1,000 times improved temporal resolu...
-
作者：Bao, Shu-Jin; Zou, Yan; Zhang, Hai-Ning; Jin, Guo-Xin
作者单位：Fudan University
摘要：Although mechanically interlocked molecules (MIMs) display unique properties and functions associated with their intricate connectivity, limited assembly strategies are available for their synthesis. Herein, we presented a synergistic assembly strategy based on coordination and noncovalent interactions (pi-pi stacking and CH & ctdot;pi interactions) to selectively synthesize molecular closed three- link chains ( 631 links), highly entangled figure- eight knots ( 41 knots), trefoil knot ( 31 kn...
-
作者：Ghio, Davide; Dandi, Yatin; Krzakala, Florent; Zdeborova, Lenka
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Recent years witnessed the development of powerful generative models based on flows, diffusion, or autoregressive neural networks, achieving remarkable success in generating data from examples with applications in a broad range of areas. A theoretical analysis of the performance and understanding of the limitations of these methods remain, however, challenging. In this paper, we undertake a step in this direction by analyzing the efficiency of sampling by these methods on a class of problems w...
-
作者：Martin, Jonathan; Mateos, Marcos Lequerica; Onuchic, Jose N.; Coluzza, Ivan; Morcos, Faruck
作者单位：University of Texas System; University of Texas Dallas; BCMaterials; Rice University; Rice University; Rice University; Rice University; Basque Foundation for Science; University of Texas System; University of Texas Dallas
摘要：Machine learning has been proposed as an alternative to theoretical modeling when dealing with complex problems in biological physics. However, in this perspective, we argue that a more successful approach is a proper combination of these two methodologies. We discuss how ideas coming from physical modeling neuronal processing led to early formulations of computational neural networks, e.g., Hopfield networks. We then show how modern learning approaches like Potts models, Boltzmann machines, a...
-
作者：Washington, Stuart D.; Shattuck, Kyle; Steckel, Jan; Peremans, Herbert; Jonckers, Elisabeth; Hinz, Rukun; Venneman, Tom; Van den Berg, Monica; Van Ruijssevelt, Lisbeth; Verellen, Thomas; Pritchett, Dominique L.; Scholliers, Jan; Liang, Sayuan; Wang, Paul C.; Verhoye, Marleen; Esser, Karl-Heinz; Van der Linden, Annemie; Keliris, Georgios A.
作者单位：University of Antwerp; Massachusetts Institute of Technology (MIT); Howard University; Howard University; Georgetown University; Georgetown University; University of Antwerp; University of Antwerp; University of Antwerp; Howard University; University of Antwerp; University of Antwerp; Fu Jen Catholic University; University of Veterinary Medicine Hannover; Foundation for Research & Technology - Hellas (FORTH); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
摘要：Echolocating bats are among the most social and vocal of all mammals. These animals are ideal subjects for functional MRI (fMRI) studies of auditory social communication given their relatively hypertrophic limbic and auditory neural structures and their reduced ability to hear MRI gradient noise. Yet, no resting - state networks relevant to social cognition (e.g., default mode - like networks or DMLNs) have been identified in bats since there are few, if any, fMRI studies in the chiropteran or...
-
作者：Lipkowitz, Gabriel; Saccone, Max A.; Panzer, Matthew A.; Coates, Ian A.; Hsiao, Kaiwen; Ilyn, Daniel; Kronenfeld, Jason M.; Tumbleston, John R.; Shaqfeh, Eric S. G.; DeSimone, Joseph M.
作者单位：Stanford University; Stanford University; Stanford University; Stanford University
摘要：Vat photopolymerization (VP) additive manufacturing enables fabrication of complex 3D objects by using light to selectively cure a liquid resin. Developed in the 1980s, this technique initially had few practical applications due to limitations in print speed and final part material properties. In the four decades since the inception of VP, the field has matured substantially due to simultaneous advances in light delivery, interface design, and materials chemistry. Today, VP materials are used ...
-
作者：Liu, Bing-Qi; Bao, Xi-Yu; Yan, Jin-Yang; Zhang, Dan; Sun, Xiang; Li, Chu-Qiao; Chen, Zhan-Bo; Luan, Jun-Bo
作者单位：Shenyang Agricultural University
摘要：Heritable symbionts are common among animals in nature, but the molecular mechanisms underpinning symbiont invasions of host populations have been elusive. In this study, we demonstrate the spread of Rickettsia in an invasive agricultural pest, the whitefly Bemisia tabaci Mediterranean (MED), across northeastern China from 2018 to 2023. Here, we show that the beneficial symbiont Rickettsia spreads by manipulating host hormone signals. Our analyses suggest that Rickettsia have been horizontally...
-
作者：Gao, Shujuan; Rodriguez, Jake W. Carrasquillo; Bahmanyar, Shirin; Airola, Michael V.
作者单位：State University of New York (SUNY) System; Stony Brook University; Yale University
摘要：C - terminal Domain Nuclear Envelope Phosphatase 1 (CTDNEP1) is a noncanonical protein serine/threonine phosphatase that has a conserved role in regulating ER membrane biogenesis. Inactivating mutations in CTDNEP1 correlate with the development of medulloblastoma, an aggressive childhood cancer. The transmembrane protein Nuclear Envelope Phosphatase 1 Regulatory Subunit 1 (NEP1R1) binds CTDNEP1, but the molecular details by which NEP1R1 regulates CTDNEP1 function are unclear. Here, we find tha...
