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作者：Jahnke, Kevin; Pavlovic, Marko; Xu, Wentao; Chen, Anqi; Knowles, Tuomas P. J.; Arriaga, Laura R.; Weitz, David A.
作者单位：Harvard University; University of Cambridge; Autonomous University of Madrid; Autonomous University of Madrid; Harvard University; Harvard University
摘要：The biophysical properties of lipid vesicles are important for their stability and integrity, key parameters that control the performance when these vesicles are used for drug delivery. The vesicle properties are determined by the composition of lipids used to form the vesicle. However, for a given lipid composition, they can also be tailored by tethering polymers to the membrane. Typically, synthetic polymers like polyethyleneglycol are used to increase vesicle stability, but the use of polys...
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作者：Scaletti, Carla; Russell, Premila P. Samuel; Hebel, Kurt J.; Rickard, Meredith M.; Boob, Mayank; Danksagmueller, Franz; Taylor, Stephen A.; V. Pogorelov, Taras; Gruebele, Martin
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Protein-protein and protein-water hydrogen bonding interactions play essential roles in the way a protein passes through the transition state during folding or unfolding, but the large number of these interactions in molecular dynamics (MD) simulations makes them difficult to analyze. Here, we introduce a state space representation and associated rarity measure to identify and quantify transition state passage (transit) events. Applying this representation to a long MD simulation trajectory th...
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作者：Fu, Haochen; Fei, Chenyi; Ouyang, Qi; Tu, Yuhai
作者单位：University of California System; University of California San Diego; Massachusetts Institute of Technology (MIT); Peking University; International Business Machines (IBM); IBM USA
摘要：Nearly all circadian clocks maintain a period that is insensitive to temperature changes, a phenomenon known as temperature compensation (TC). Yet, it is unclear whether there is any common feature among different systems that exhibit TC. From a general timescale invariance, we show that TC relies on the existence of certain periodlengthening reactions wherein the period of the system increases strongly with the rates in these reactions. By studying several generic oscillator models, we show t...
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作者：Mizera, Jiri; Strunga, Vladimir
作者单位：Czech Academy of Sciences; Nuclear Physics Institute of the Czech Academy of Sciences; Czech Academy of Sciences; Institute of Rock Structure & Mechanics of the Czech Academy of Sciences
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作者：Yang, Chen; Dong, Xinrui; Sun, Bingrui; Cao, Ting; Xie, Ruipei; Zhang, Yiyu; Yang, Ziyue; Huang, Jing; Lu, Ying; Li, Ming; Wang, Xiaochen; Xu, Ye; Ye, Fangfu; Fan, Qihui
作者单位：Beihang University; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang University; Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Oujiang Laboratory
摘要：The significance of biochemical cues in the tumor immune microenvironment in affecting cancer metastasis is well established, but the role of physical factors in the microenvironment remains largely unexplored. In this article, we investigated how the mechanical interaction between cancer cells and immune cells, mediated by extracellular matrix (ECM), influences immune escape of cancer cells. We focus on the mechanical regulation of macrophages' targeting ability on two distinct types of color...
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作者：Ashokan, Akash; Sarkar, Shrita; Kamran, Mohammad Z.; Surnar, Bapurao; Kalathil, Akil A.; Spencer, Alexis; Dhar, Shanta
作者单位：University of Miami; University of Miami; University of Miami
摘要：Brain metastasis of advanced breast cancer often results in deleterious consequences. Metastases to the brain lead to significant challenges in treatment options, as the blood- brain barrier (BBB) prevents conventional therapy. Thus, we hypothesized that creation of a nanoparticle (NP) that distributes to both primary tumor site and across the BBB for secondary brain tumor can be extremely beneficial. Here, we report a simple targeting strategy to attack both the primary breast and secondary b...
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作者：Fromm, Katja; Ortelli, Monica; Boegli, Alexandra; Dehio, Christoph
作者单位：University of Basel; University of Lausanne
摘要：The evolutionary conserved YopJ family comprises numerous type- III- secretion system (T3SS) effectors of diverse mammalian and plant pathogens that acetylate host proteins to dampen immune responses. Acetylation is mediated by a central acetyltransferase domain that is flanked by conserved regulatory sequences, while a nonconserved N- terminal extension encodes the T3SS- specific translocation signal. Bartonella spp. are facultative- intracellular pathogens causing intraerythrocytic bacteremi...
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作者：Maloney, Ashley E.; Kopf, Sebastian H.; Zhang, Zhaoyue; Mcfarlin, Jamie; Nelson, Daniel B.; Masterson, Andrew L.; Zhang, Xinning
作者单位：Princeton University; University of Colorado System; University of Colorado Boulder; Princeton University; Princeton University; University of Wyoming; University of Basel; Northwestern University; Princeton University
摘要：Shifts in the hydrogen stable isotopic composition (H-2/H-1 ratio) of lipids relative to water (lipid/water H-2-fractionation) at natural abundances reflect different sources of the central cellular reductant, NADPH, in bacteria. Here, we demonstrate that lipid/water H-2-fractionation ((2)epsilon(fattyacid/water)) can also constrain the relative importance of key NADPH pathways in eukaryotes. We used the metabolically flexible yeast Saccharomyces cerevisiae, a microbial model for respiratory a...
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作者：Marshall, Adrienne M.; Abatzoglou, John T.; Rahimi, Stefan; Lettenmaier, Dennis P.; Hall, Alex
作者单位：Colorado School of Mines; University of California System; University of California Merced; University of Wyoming; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：The increasing prevalence of low snow conditions in a warming climate has attracted substantial attention in recent years, but a focus exclusively on low snow leaves high snow years relatively underexplored. However, these large snow years are hydrologically and economically important in regions where snow is critical for water resources. Here, we introduce the term snow deluge and use anomalously high snowpack in California's Sierra Nevada during the 2023 water year as a case study. Snow moni...
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作者：[Anonymous]
