Auditory cortical regions show resting- state functional connectivity with the default mode- like network in echolocating bats

• 成果类型: Article
• 署名作者: Washington, Stuart D.; Shattuck, Kyle; Steckel, Jan; Peremans, Herbert; Jonckers, Elisabeth; Hinz, Rukun; Venneman, Tom; Van den Berg, Monica; Van Ruijssevelt, Lisbeth; Verellen, Thomas; Pritchett, Dominique L.; Scholliers, Jan; Liang, Sayuan; Wang, Paul C.; Verhoye, Marleen; Esser, Karl-Heinz; Van der Linden, Annemie; Keliris, Georgios A.
• 署名单位: University of Antwerp; Massachusetts Institute of Technology (MIT); Howard University; Howard University; Georgetown University; Georgetown University; University of Antwerp; University of Antwerp; University of Antwerp; Howard University; University of Antwerp; University of Antwerp; Fu Jen Catholic University; University of Veterinary Medicine Hannover; Foundation for Research & Technology - Hellas (FORTH); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-13691
• DOI: 10.1073/pnas.2306029121
• 发表日期: 2024-07-02
• 关键词: phyllostomus-discolor; cortex; REPRESENTATION; lateralization; selectivity; plasticity; motivation; direction; PATHWAY; sounds

摘要

Echolocating bats are among the most social and vocal of all mammals. These animals are ideal subjects for functional MRI (fMRI) studies of auditory social communication given their relatively hypertrophic limbic and auditory neural structures and their reduced ability to hear MRI gradient noise. Yet, no resting - state networks relevant to social cognition (e.g., default mode - like networks or DMLNs) have been identified in bats since there are few, if any, fMRI studies in the chiropteran order. Here, we acquired fMRI data at 7 Tesla from nine lightly anesthetized pale spear - nosed bats ( Phyllostomus discolor ). We applied independent components analysis (ICA) to reveal resting - state networks and measured neural activity elicited by noise ripples (on: 10 ms; off: 10 ms) that span this species' ultrasonic hearing range (20 to 130 kHz). Resting - state networks pervaded auditory, parietal, and occipital cortices, along with the hippocampus, cerebellum, basal ganglia, and auditory brainstem. Two midline networks formed an apparent DMLN. Additionally, we found four predominantly auditory/parietal cortical networks, of which two were left - lateralized and two right - lateralized. Regions within four auditory/parietal cortical networks are known to respond to social calls. Along with the auditory brainstem, regions within these four cortical networks responded to ultrasonic noise ripples. Iterative analyses revealed consistent, significant functional connectivity between the left, but not right, auditory/parietal cortical networks and DMLN nodes, especially the anterior - most cingulate cortex. Thus, a resting - state network implicated in social cognition displays more distributed functional connectivity across left, relative to right, hemispheric cortical substrates of audition and communication in this highly social and vocal species.