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作者：Varshavsky, Alexander
作者单位：California Institute of Technology
摘要：An N- degron is a degradation signal whose main determinant is a destabilizing N- terminal residue of a protein. Specific N- degrons, discovered in 1986, were the first identified degradation signals in short- lived intracellular proteins. These N- degrons are recognized by a ubiquitin- dependent proteolytic system called the Arg/N- degron pathway. Although bacteria lack the ubiquitin system, they also have N- degron pathways. Studies after 1986 have shown that all 20 amino acids of the geneti...
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作者：Uribe-Cano, Santiago; Kottmann, Andreas H.
作者单位：New York University; City University of New York (CUNY) System
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作者：Kim, Ji Yeon; Lee, Jong An; Ahn, Jung Ho; Lee, Sang Yup
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Institute of Science & Technology (KIST)
摘要：Succinic acid (SA), a dicarboxylic acid of industrial importance, can be efficiently produced by metabolically engineered Mannheimia succiniciproducens. Although the importance of magnesium (Mg2+) ion on SA production has been evident from our previous studies, the role of Mg2+ ion remains largely unexplored. In this study, we investigated the impact of Mg2+ ion on SA production and developed a hyper- SA producing strain of M. succiniciproducens by reconstructing the Mg2+ ion transport system....
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作者：Borovska, Petra; de Haas, Benjamin
作者单位：Justus Liebig University Giessen
摘要：Complex visual stimuli evoke diverse patterns of gaze, but previous research suggests that their neural representations are shared across brains. Here, we used hyperalignment to compare visual responses between observers viewing identical stimuli. We find that individual eye movements enhance cortical visual responses but also lead to representational divergence. Pairwise differences in the spatial distribution of gaze and in semantic salience predict pairwise representational divergence in V1...
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作者：Tian, Yijie; Koncz, Istvan; Defant, Sarah; Giostra, Caterina; Vyas, Deven N.; Soltysiak, Arkadiusz; Baricco, Luisella Pejrani; Fetner, Rafal; Posth, Cosimo; Brandt, Guido; Bedini, Elena; Modi, Alessandra; Lari, Martina; Vai, Stefania; Francalacci, Paolo; Fernandes, Ricardo; Steinhof, Axel; Pohl, Walter; Caramelli, David; Krause, Johannes; Izdebski, Adam; Geary, Patrick J.; Veeramah, Krishna R.
作者单位：State University of New York (SUNY) System; Stony Brook University; Eotvos Lorand University; Free University of Berlin; Max Planck Society; Free University of Berlin; Catholic University of the Sacred Heart; University of Warsaw; Eberhard Karls University of Tubingen; Max Planck Society; University of Florence; University of Cagliari; Masaryk University; Princeton University; Max Planck Society; Austrian Academy of Sciences; University of Vienna; Jagiellonian University; Institute for Advanced Study - USA
摘要：Elites played a pivotal role in the formation of post- Roman Europe on both macro- and microlevels during the Early Medieval period. History and archaeology have long focused on their description and identification based on written sources or through their archaeological record. We provide a different perspective on this topic by integrating paleogenomic, archaeological, and isotopic data to gain insights into the role of one such elite group in a Langobard period community near Collegno, Ital...
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作者：Madl, Christopher M.; Wang, Yu Xin; Holbrook, Colin A.; Su, Shiqi; Shi, Xuechen; Byfield, Fitzroy J.; Wicki, Gwendoline; Flaig, Iris A.; Blau, Helen M.
作者单位：Stanford University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Muscle stem cells (MuSCs) are specialized cells that reside in adult skeletal muscle poised to repair muscle tissue. The ability of MuSCs to regenerate damaged tissues declines markedly with aging and in diseases such as Duchenne muscular dystrophy, but the underlying causes of MuSC dysfunction remain poorly understood. Both aging and disease result in dramatic increases in the stiffness of the muscle tissue microenvironment from fibrosis. MuSCs are known to lose their regenerative potential i...
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作者：Reed, Kevin B.; Kim, Wantae; Lu, Hongyuan; Larue, Clayton T.; Guo, Shirley; Brooks, Sierra M.; Montez, Michael R.; Wagner, James M.; Zhang, Y. Jessie; Alper, Hal S.
作者单位：University of Texas System; University of Texas Austin; Bayer AG; Bayer CropScience; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：The enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) functions in the shikimate pathway which is responsible for the production of aromatic amino acids and precursors of other essential secondary metabolites in all plant species. EPSPS is also the molecular target of the herbicide glyphosate. While some plant EPSPS variants have been characterized with reduced glyphosate sensitivity and have been used in biotechnology, the glyphosate insensitivity typically comes with a cost to catal...
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作者：Song, Shikai; Yang, Shixin; Zheng, Ruicheng; Yin, Dandan; Cao, Yue; Wang, Yao; Qiao, Lu; Bai, Rina; Wang, Shuge; Yin, Wenjuan; Dong, Yanjun; Bai, Li; Yang, Hui; Shen, Jianzhong; Wu, Congming; Hu, Fupin; Wang, Yang
作者单位：China Agricultural University; Shandong Academy of Agricultural Sciences; Fudan University; Hebei University
摘要：is a growing concern due to its high mortality and limited treatment options. Although hypermucoviscosity is crucial for CR- hvKp infection, the role of changes in bacterial mucoviscosity in the host colonization and persistence of CR- hvKp is not clearly defined. Herein, we observed a phenotypic switch of CR- hvKp from a hypermucoviscous to a hypomucoviscous state in a patient with scrotal abscess and urinary tract infection (UTI). This switch was attributed to decreased expression of rmpADC,...
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作者：Xiong, Ame; Richmond, Janet E.; Kim, Hongkyun
作者单位：Chicago Medical School; Rosalind Franklin University of Medicine & Science; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要：The abundance of CaV2 voltage- gated calcium channels is linked to presynaptic homeostatic plasticity (PHP), a process that recalibrates synaptic strength to maintain the stability of neural circuits. However, the molecular and cellular mechanisms governing PHP and CaV2 channels are not completely understood. Here, we uncover a previously not described form of PHP in Caenorhabditis elegans, revealing an inverse regulatory relationship between the efficiency of neurotransmitter release and the ...
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作者：Ye, Zhengwei; Yang, Ke R.; Zhang, Bingxing; Navid, Ishtiaque Ahmed; Shen, Yifan; Xiao, Yixin; Pofelski, Alexandre; Botton, Gianluigi A.; Ma, Tao; Mondal, Shubham; Norris, Theodore B.; Batista, Victor S.; Mi, Zetian
作者单位：University of Michigan System; University of Michigan; Yale University; Yale University; McMaster University; University of Michigan System; University of Michigan
摘要：The conversion of CO2 into liquid fuels, using only sunlight and water, offers a promising path to carbon neutrality. An outstanding challenge is to achieve high efficiency and product selectivity. Here, we introduce a wireless photocatalytic architecture for conversion of CO2 and water into methanol and oxygen. The catalytic material consists of semiconducting nanowires decorated with core-shell nanoparticles, with a copper- rhodium core and a chromium oxide shell. The Rh/CrOOH interface prov...
