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作者：Romagnano, Valentina; Kubon, Julian; Sokolov, Alexander N.; Fallgatter, Andreas J.; Braun, Christoph; Pavlova, Marina A.
作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital
摘要：Face pareidolia is a tendency to seeing faces in nonface images that reflects high tuning to a face scheme. Yet, studies of the brain networks underwriting face pareidolia are scarce. Here, we examined the time course and dynamic topography of gamma oscillatory neuromagnetic activity while administering a task with nonface images resembling a face. Images were presented either with canonical orientation or with display inversion that heavily impedes face pareidolia. At early processing stages,...
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作者：Wang, Zhaoqian; Mccallum, Matthew; Yan, Lianying; Gibson, Cecily A.; Sharkey, William; Park, Young - Jun; V. Dang, Ha; Amaya, Moushimi; Person, Ashley; Broder, Christopher C.; Veeslera, David
作者单位：University of Washington; University of Washington Seattle; Uniformed Services University of the Health Sciences - USA; Howard Hughes Medical Institute
摘要：Langya virus (LayV) is a recently discovered henipavirus (HNV), isolated from febrile patients in China. HNV entry into host cells is mediated by the attachment (G) and fusion (F) glycoproteins which are the main targets of neutralizing antibodies. We show here that the LayV F and G glycoproteins promote membrane fusion with human, mouse, and hamster target cells using a different, yet unknown, receptor than Nipah virus (NiV) and Hendra virus (HeV) and that NiV- and HeV- elicited monoclonal an...
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作者：Martinez-Fernandez, Irene; Fourquin, Chloe; Lindsay, Donna; Berbel, Ana; Balanza, Vicente; Huang, Shaoming; Dalmais, Marion; Lesignor, Christine; Bendahmane, Abdelhafid; Warkentin, Thomas D.; Madueno, Francisco; Ferrandiz, Cristina; Coupland, George
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universitat Politecnica de Valencia; CSIC-UPV - Instituto de Biologia Molecular y Celular de Plantas (IBMCP); University of Saskatchewan; Universite Paris Saclay; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; INRAE; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); INRAE; Universite Bourgogne Europe; Institut Agro; AgroSup Dijon
摘要：Monocarpic plants have a single reproductive phase in their life. Therefore, flower and fruit production are restricted to the length of this period. This reproductive strategy involves the regulation of flowering cessation by a coordinated arrest of the growth of the inflorescence meristems, optimizing resource allocation to ensure seed filling. Flowering cessation appears to be a regulated phenomenon in all monocarpic plants. Early studies in several species identified seed production as a m...
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作者：Nasiri, Mahdi; Loran, Edwin; Liebchen, Benno
作者单位：Technical University of Darmstadt
摘要：Throughout evolution, bacteria and other microorganisms have learned efficient foraging strategies that exploit characteristic properties of their unknown environment. While much research has been devoted to the exploration of statisticalmodels describing the dynamics of foraging bacteria and other (micro-) organisms, little is known, regarding the question of how good the learned strategies actually are. This knowledge gap is largely caused by the absence of methods allowing to systematically...
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作者：Xu, Zenghui; Zhuo, La; Feng, Bianbian; Li, Meng; Wang, Wei; Huang, Hongrong; Wu, Pute
作者单位：Northwest A&F University - China; Northwest A&F University - China; Ministry of Water Resources; Chinese Academy of Sciences; Institute of Soil & Water Conservation (ISWC), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Institute of Soil & Water Conservation (ISWC), CAS; Dongguan University of Technology
摘要：Corrugated packaging for express grew by 90 times to 16.5 Mt y-1 in China, where 81% of recent global express delivery growth occurred. However, the environmental impacts of production, usage, disposal, and recycling of corrugated boxes under the entire supply chain remain unclear. Here, we estimate the magnitudes, drivers, and mitigation potentials of cradle-to-grave life-cycle carbon footprint (CF) and three colors of water footprints (WFs) for corrugated cardboard packaging in China. Over 2...
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作者：Tian, Zhong-qi K.; Chen, Kai; Li, Songting; Mclaughlind, David W.; Zhou, Douglas
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; New York University; New York University; New York University; NYU Shanghai; New York University; Shanghai Jiao Tong University
摘要：The causal connectivity of a network is often inferred to understand network function. It is arguably acknowledged that the inferred causal connectivity relies on the causality measure one applies, and it may differ from the network's underlying structural connectivity. However, the interpretation of causal connectivity remains to be fully clarified, in particular, how causal connectivity depends on causality measures and how causal connectivity relates to structural connectivity. Here, we foc...
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作者：Chuaychob, Surachada; Lyu, Ruyin; Tanaka, Miwa; Haginiwa, Ayumi; Kitada, Atsuya; Nakamura, Takuro; Yokokawa, Ryuji
作者单位：Kyoto University; Japanese Foundation for Cancer Research; Tokyo Medical University
摘要：Alveolar soft - part sarcoma (ASPS) is a slow- growing soft tissue sarcoma with high mortality rates that affects adolescents and young adults. ASPS resists conventional chemotherapy; thus, decades of research have elucidated pathogenic mechanisms driving the disease, particularly its angiogenic capacities. Integrated blood vessels that are rich in pericytes (PCs) and metastatic potential are distinctive of ASPS. To mimic ASPS angiogenic microenvironment, a microfluidic coculture vasculature c...
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作者：Yang, Jonathan Lee; Yamada-Hunter, Sean A.; Labanieh, Louai; Sotillo, Elena; Cheah, Joleen S.; Roberts, David S.; Mackall, Crystal L.; Bertozzi, Carolyn R.; Ting, Alice Y.
作者单位：Stanford University; Stanford University; Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Lysosome- targeting chimeras (LYTACs) are a promising therapeutic modality to drive the degradation of extracellular proteins. However, early versions of LYTAC contain synthetic glycopeptides that cannot be genetically encoded. Here, we present our designs for a fully genetically encodable LYTAC (GELYTAC), making our tool compatible with integration into therapeutic cells for targeted delivery at diseased sites. To achieve this, we replaced the glycopeptide portion of LYTACs with the protein i...
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作者：Berger, Simone; Laechelt, Ulrich; Wagner, Ernst
作者单位：University of Munich; University of Munich; University of Vienna
摘要：Carriers for RNA delivery must be dynamic, first stabilizing and protecting therapeutic RNA during delivery to the target tissue and across cellular membrane barriers and then releasing the cargo in bioactive form. The chemical space of carriers ranges from small cationic lipids applied in lipoplexes and lipid nanoparticles, over medium- sized sequence- defined xenopeptides, to macromolecular poly-cations applied in polyplexes and polymer micelles. This perspective highlights the discovery of ...
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作者：Giubertoni, Giulia; Feng, Liru; Klein, Kevin; Giannetti, Guido; Rutten, Luco; Choi, Yeji; van der Net, Anouk; Castro-Linares, Gerard; Caporaletti, Federico; Micha, Dimitra; Hunger, Johannes; Deblais, Antoine; Bonn, Daniel; Sommerdijk, Nico; Saric, Andela; Ilie, Ioana M.; Koenderink, Gijsje H.; Woutersen, Sander
作者单位：University of Amsterdam; Institute of Science & Technology - Austria; University of London; University College London; Radboud University Nijmegen; Max Planck Society; Delft University of Technology; University of Amsterdam; University of Amsterdam; University of Amsterdam
摘要：Water is known to play an important role in collagen self -assembly, but it is still largely unclear how water-collagen interactions influence the assembly process and determine the fibril network properties. Here, we use the H2O/D2O isotope effect on the hydrogen -bond strength in water to investigate the role of hydration in collagen selfassembly. We dissolve collagen in H2O and D2O and compare the growth kinetics and the structure of the collagen assemblies formed in these water isotopomers...
