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作者：Taeb, Armeen; Buhlmann, Peter; Chandrasekaran, Venkat
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作者：Wheeler, Hailey B.; Madrigal, Assael A.; Chaim, Isaac A.
作者单位：University of California System; University of California San Diego
摘要：Over two decades ago, increased levels of RNA oxidation were reported in postmortem patients with ALS, Alzheimer's, Parkinson's, and other neurodegenerative diseases. Interestingly, not all cell types and transcripts were equally oxidized. Furthermore, it was shown that RNA oxidation is an early phenomenon, altogether indicating that oxidative RNA damage could be a driver, and not a consequence, of disease. Despite all these exciting observations, the field appears to have stagnated since then...
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作者：Zhu, Julia Li; Chau, Nancy; Rodewald, Amanda D.; Garip, Filiz
作者单位：California State University System; San Diego State University; Cornell University; Cornell University; Princeton University; Princeton University
摘要：As the world's climate continues to change, human populations are exposed to increasingly severe and extreme weather conditions that can promote migration. Here, we examine how extreme weather influences the likelihood of undocumented migration and return between Mexico and the United States. We used data from 48,313 individuals observed between 1992 and 2018 in 84 Mexican agricultural communities. While controlling for regional and temporal confounding factors, we related individual decisions...
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作者：Cho, Jae Sung; Luo, Zi Wei; Moon, Cheon Woo; Prabowo, Cindy Pricilia Surya; Lee, Sang Yup
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
摘要：Environmental concerns from plastic waste are driving interest in alternative monomers from bio- based sources. Pseudoaromatic dicarboxylic acids are promising alternatives with chemical structures similar to widely used petroleum- based aromatic dicarboxylic acids. However, their use in polyester synthesis has been limited due to production challenges. Here, we report the fermentative production of five pseudoaromatic dicarboxylic acids, including 2- pyrone- 4,6- dicarboxylic acid (PDC) and p...
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作者：Denchfield, Adam; Park, Hyowon; Hemley, Russell J.
作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; United States Department of Energy (DOE); Argonne National Laboratory; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要：While hydrogen-rich materials have been demonstrated to exhibit high Tc superconductivity at high pressures, there is an ongoing search for ternary, quaternary, and more chemically complex hydrides that achieve such high critical temperatures at much lower pressures. First-principles searches are impeded by the computational complexity of solving the Eliashberg equations for large, complex crystal structures. Here, we adopt a simplified approach using electronic indicators previously establish...
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作者：Kawakatsu, Mari; Kessinger, Taylor A.; Plotkin, Joshua B.
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作者：Ulrich, Nicole D.; Vargo, Alex; Ma, Qianyi; Shen, Yu - chi; Bazzano, Dominic; Hannum, D. Ford; Gurczynski, Stephen J.; Moore, Bethany B.; Schon, Samantha; Lieberman, Richard; Shikanov, Ariella; Marsh, Erica E.; Fazleabas, Asgerally; Li, Jun Z.; Hammoud, Saher Sue
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Michigan State University; University of Michigan System; University of Michigan
摘要：The human uterus is a complex and dynamic organ whose lining grows, remodels, and regenerates every menstrual cycle or upon tissue damage. Here, we applied single- cell RNA sequencing to profile more the 50,000 uterine cells from both the endometrium and myometrium of five healthy premenopausal individuals, and jointly analyzed the data with a previously published dataset from 15 subjects. The resulting normal uterus cell atlas contains more than 167K cells, representing the lymphatic endothel...
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作者：Akandil, Cengiz; Plekhanova, Elena; Rietze, Nils; Oehri, Jacqueline; Roman, Miguel O.; Wang, Zhuosen; Radeloff, Volker C.; Strub, Gabriela Schaepman -
作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Wisconsin System; University of Wisconsin Madison
摘要：Climate warming enables easier access and operation in the Arctic, fostering industrial and urban development. However, there is no comprehensive pan- Arctic overview of industrial and urban development, which is crucial for the planning of sustainable development of the region. In this study, we utilize satellite- derived artificial light at night (ALAN) data to quantify the hotspots and the development of light- emitting human activity across the Arctic from 1992 to 2013. We find that out of...
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作者：Li, He; Qiang, Yuhao; Li, Xuejin; Brugnara, Carlo; Buffet, Pierre A.; Dao, Ming; Karniadakis, George E.; Suresh, Subra
作者单位：University System of Georgia; University of Georgia; Massachusetts Institute of Technology (MIT); Zhejiang University; Zhejiang University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Brown University; Brown University
摘要：The clearance of senescent and altered red blood cells (RBCs) in the red pulp of the human spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior work has elucidated the mechanisms underlying the first two processes, biomechanical processes driving the postfiltration phagocytosis of RBCs retained at interendothelial slits (IES) are still poorly understood. We present here a unique computational model of macrophages to study the role of cell biomechan...
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作者：Ma, Xiqi; Zhang, Zhixiong; Barba-Bon, Andrea; Han, Dongxue; Qi, Zichun; Ge, Baosheng; He, Hua; Huang, Fang; Nau, Werner M.; Wang, Xiaojuan
作者单位：China University of Petroleum; Constructor University
摘要：Intracellular protein delivery has the potential to revolutionize cell- biological research and medicinal therapy, with broad applications in bioimaging, disease treatment, and genome editing. Herein, we demonstrate successful delivery of a functional protein, cytochrome c (CYC), by using a boron cluster anion as molecular carrier of the superchaotropic anion type (B12Br11OPr2-). CYC was delivered into lipid bilayer vesicles as well as living cells, with a cellular uptake ratio approaching 90%...
