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作者：Tian, Jing; Goldstein, Joseph L.; Li, Shili; Schumacher, Marc M.; Brown, Michael S.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：Insig-1 and Insig-2 are endoplasmic reticulum (ER) proteins that inhibit lipid synthesis by blocking transport of sterol regulatory element- binding proteins (SREBP-1 and SREBP-2) from ER to Golgi. In the Golgi, SREBPs are processed proteolytically to release their transcription- activating domains, which enhance the synthesis of fatty acids, triglycerides, and cholesterol. Heretofore, the two Insigs have redundant functions, and there is no rationale for two isoforms. The current data identif...
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作者：Valente, Christine; Toh, Wen Qiang; Jalingo, Inuwa; Lepine, Aurelia; de Paula, Aureo; Miller, Grant
作者单位：University of Bristol; Erasmus University Rotterdam - Excl Erasmus MC; Erasmus University Rotterdam; University of London; University College London; University of London; University College London; University of London; London School Economics & Political Science; Stanford University; National Bureau of Economic Research
摘要：Desired fertility measures are routinely collected and used by researchers and policy makers, but their self-reported nature raises the possibility of reporting bias. In this paper, we test for the presence of such bias by comparing responses to direct survey questions with indirect questions offering a varying, randomized, degree of confidentiality to respondents in a socioeconomically diverse sample of Nigerian women (N = 6,256). We find that women report higher fertility preferences when as...
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作者：Zhou, Yu; Reddy, Curran; Zhang, Xudong
作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station
摘要：The human neck is a unique mechanical structure, highly flexible but fatigue prone. The rising prevalence of neck pain and chronic injuries has been attributed to increasing exposure to fatigue loading in activities such as prolonged sedentary work and overuse of electronic devices. However, a causal relationship between fatigue and musculoskeletal mechanical changes remains elusive. This work aimed to establish this relationship through a unique experiment design, inspired by a cantilever bea...
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作者：Roth, Jonathan; Hoop, Cody; Williams, Jonathan K.; Nanda, Vikas; Baum, Jean
作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Bristol-Myers Squibb
摘要：The hierarchic assembly of fibrillar collagen into an extensive and ordered supramolecular protein fibril is critical for extracellular matrix function and tissue mechanics. Despite decades of study, we still know very little about the complex process of fibrillogenesis, particularly at the earliest stages where observation of rapidly forming, nanoscale intermediates challenges the spatial and temporal resolution of most existing microscan observe details of the first few minutes of collagen f...
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作者：Jiang, Haihui Joy; Underwood, Thomas C.; Bell, Jeffrey G.; Lei, Jonathan; Gonzales, Joe C.; Emge, Lukas; Tadese, Leah G.; Rahman, Mohamed K. Abd El-; Wilmouth, David M.; Brazaca, Lais C.; Ni, Gigi; Belding, Lee; Dey, Supriya; Ashkarran, Ali Akbar; Nagarkar, Amit; Nemitz, Markus P.; Cafferty, Brian J.; Sayres, David S.; Ranjan, Sukrit; Crocker, Daniel R.; Anderson, James G.; Sasselov, Dimitar D.; Whitesides, George M.
作者单位：Harvard University; Harvard University; University of Texas System; University of Texas Austin; Harvard University; University of Arizona; University of Arizona; Harvard University
摘要：To test the hypothesis that an abiotic Earth and its inert atmosphere could form chemically reactive carbon- and nitrogen- containing compounds, we designed a plasma electrochemical setup to mimic lightning- induced electrochemistry under steady- state conditions of the early Earth. Air- gap electrochemical reactions at air-water-ground interfaces lead to remarkable yields, with up to 40 moles of carbon dioxide being reduced into carbon monoxide and formic acid, and 3 moles of gaseous nitrogen...
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作者：Li, Yong; Wen, Yiling; Li, Ying; Tan, Xinyi; Gao, Shuaixin; Fan, Peiyao; Tian, Wenmin; Wong, Catherine C. L.; Chen, Yang
作者单位：Peking University; Peking University; Tsinghua University; Chinese Academy of Sciences; Institute of Biophysics, CAS; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
摘要：Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal component of their cargoes. The mechanism underlying the transportation of these intraluminal vesicles to the migrasomes remains enigmatic. In this study, we identified that Rab10 and Caveolin- 1 (CAV1) mark th...
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作者：Mason, Alexander H.; Motta, Alessandro; Kratish, Yosi; Marks, Tobin J.
作者单位：Northwestern University; Northwestern University; Sapienza University Rome
摘要：A kinetic/mechanistic investigation of gaseous propane hydrogenolysis over the single-site heterogeneous polyolefin depolymerization catalysts AlS/ZrNp2 and AlS/HfNp2 (AlS = sulfated alumina, Np = neopentyl), is use to probe intrinsic catalyst properties without the complexities introduced by time- and viscosity-dependent polymer medium effects. In a polymer-free automated plug-flow catalytic reactor, propane hydrogenolysis turnover frequencies approach 3,000 h(-1) at 150 degrees C. Both catal...
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作者：Zhou, Qixing; Xue, Wendan; Cui, Xun; Wang, Pengfei; Zuo, Sijin; Mo, Fan; Li, Chengzhi; Liu, Gaolei; Ouyang, Shaohu; Zhan, Sihui; Chen, Juan; Wang, Chao
作者单位：Nankai University; Wuhan Textile University; China Pharmaceutical University; Hohai University
摘要：Rechargeable zinc-air batteries (ZABs) are regarded as a remarkably promising alternative to current lithium- ion batteries, addressing the requirements for large- scale high- energy storage. Nevertheless, the sluggish kinetics involving oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) hamper the widespread application of ZABs, necessitating the development of high- efficiency and durable bifunctional electrocatalysts. Here, we report oxygen atom-bridged Fe, Co dual- metal d...
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作者：Ma, Qianqian; Han, Xiao; Zhu, Kexin; He, Danxia; Ng, Cai Xin; Miao, Yansong
作者单位：Nanyang Technological University; Nanyang Technological University
摘要：The dynamic organization of the actin cytoskeleton, crucial for numerous cellular processes, is intricately regulated by the nucleotide state of actin filaments (F-actin). Visualization tools for specifically detecting ADP-bound F-actin, however, remain limited. Here, we introduce ADPact, a 20-amino-acid peptide that selectively binds to ADP-F-actin. ADPact allows for the precise visualization of ADP-F-actin structures both in vitro and in eukaryotic cells, particularly under energy stress con...
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作者：Alonso-Matilla, Roberto; Lam, Alice R.; Miettinen, Teemu P.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Massachusetts Institute of Technology (MIT)
摘要：Cytokinesis is the process where the mother cell's cytoplasm separates into daughter cells. This is driven by an actomyosin contractile ring that produces cortical contractility and drives cleavage furrow ingression, resulting in the formation of a thin intercellular bridge. While cytoskeletal reorganization during cytokinesis has been extensively studied, less is known about the spatiotemporal dynamics of the plasma membrane. Here, we image and model plasma membrane lipid and protein dynamics...
