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作者：Sheriff, Killian; Cao, Yifan; Smidt, Tess; Freitas, Rodrigo
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Metallic alloys often form phases-known as solid solutions-in which chemical elements are spread out on the same crystal lattice in an almost random manner. The tendency of certain chemical motifs to be more common than others is known as chemical short-range order (SRO), and it has received substantial consideration in alloys with multiple chemical elements present in large concentrations due to their extreme configurational complexity (e.g., high-entropy alloys). SRO renders solid solutions ...
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作者：Luo, Yefei; Li, Jia; Li, Xiaoman; Lin, Haodong; Mao, Zuchao; Xu, Zhanzhan; Li, Shiwei; Nie, Chen; Zhou, Xiao Albert; Liao, Junwei; Xiong, Yundong; Xu, Xingzhi; Wang, Jiadong
作者单位：Peking University; Shenzhen University; Shenzhen University; Peking University
摘要：Transcription is extremely important for cellular processes but can be hindered by RNA polymerase II (RNAPII) pausing and stalling. Cockayne syndrome protein B (CSB) promotes the progression of paused RNAPII or initiates transcription - coupled nucleotide excision repair (TC - NER) to remove stalled RNAPII. However, the specific mechanism by which CSB initiates TC - NER upon damage remains unclear. In this study, we identified the indispensable role of the ARK2N-CK2 complex in the CSB - mediat...
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作者：Cohen, Sara B.; Urdahl, Kevin B.
作者单位：Seattle Children's Hospital; University of Washington; University of Washington Seattle
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作者：Krupovic, Mart; Kuhn, Jens H.; Fischer, Matthias G.; V. Koonin, Eugene; Redrejo, Modesto
作者单位：Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Max Planck Society; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
摘要：The phylum Preplasmiviricota (kingdom Bamfordvirae , realm Varidnaviria ) is a broad assemblage of diverse viruses with comparatively short double - stranded DNA genomes (<50 kbp) that produce icosahedral capsids built from double jelly - roll major capsid proteins. Preplasmiviricots infect hosts from all cellular domains, testifying to their ancient origin, and, in particular, are associated with six of the seven supergroups of eukaryotes. Preplasmiviricots comprise four major groups of virus...
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作者：Kurumaji, Takashi; Fang, Shiang; Ye, Linda; Kitou, Shunsuke; Checkelsky, Joseph G.
作者单位：Massachusetts Institute of Technology (MIT); Rutgers University System; Rutgers University New Brunswick; University of Tokyo
摘要：Frustrated rare - earth - based intermetallics provide a promising platform for emergent magnetotransport properties through exchange coupling between conduction electrons and localized rare - earth magnetic moments. Metamagnetism, the abrupt change of magnetization under an external magnetic field, is a signature of first - order magnetic phase transitions; recently, metamagnetic transitions in frustrated rare earth intermetallics have attracted interest for their accompanying nontrivial spin...
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作者：Qiu, Ting; Kong, Yichao; Wei, Guifeng; Sun, Kai; Wang, Ruijie; Wang, Yang; Chen, Yiji; Wang, Wenxin; Zhang, Yun; Jiang, Caihong; Yang, Peiguo; Xie, Tian; Chen, Xiabin
作者单位：Hangzhou Normal University; Hangzhou Normal University; Hangzhou Normal University; Hangzhou Normal University; Westlake University
摘要：Rearranged during transfection (RET) rearrangement oncoprotein - mediated Ras/ MAPK signaling cascade is constitutively activated in cancers. Here, we demonstrate a unique signal niche. The niche is a ternary complex based on the chimeric RET liquid- liquid phase separation. The complex comprises the rearranged kinase (RET fusion); the adaptor (GRB2), and the effector (SHC1). Together, they orchestrate the Ras/ MAPK signal cascade, which is dependent on tyrosine kinase. CCDC6 - RET fusion unde...
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作者：Kitamura, Seiya; Lin, Ting Hui; Lee, Chang Chun David; Takamura, Akihiro; Kadam, Rameshwar U.; Zhang, Ding; Zhu, Xueyong; Dada, Lucas; Nagai, Emiko; Yu, Wenli; Yao, Yao; Sharpless, K. Barry; Wilson, Ian A.; Wolan, Dennis W.
作者单位：Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Scripps Research Institute
摘要：Seasonal and pandemic - associated influenza strains cause highly contagious viral respiratory infections that can lead to severe illness and excess mortality. Here, we report on the optimization of our smallmolecule inhibitor F0045(S) targeting the influenza hemagglutinin (HA) stem with our Sulfur - Fluoride Exchange (SuFEx) click chemistry-based highthroughput medicinal chemistry (HTMC) strategy. A combination of SuFEx - and amide - based lead molecule diversification and structure - guided ...
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作者：Chen, Jizhang; Chen, Minfeng; Chen, Hongli; Yang, Ming; Han, Xiang; Ma, Dingtao; Zhang, Peixin; Wong, Ching - Ping
作者单位：Nanjing Forestry University; East China University of Science & Technology; Shenzhen University; University System of Georgia; Georgia Institute of Technology
摘要：While aqueous zinc- ion batteries exhibit great potential, their performance is impeded by zinc dendrites. Existing literature has proposed the use of hydrogel electrolytes to ameliorate this issue. Nevertheless, the mechanical attributes of hydrogel electrolytes, particularly their modulus, are suboptimal, primarily ascribed to the substantial water content. This drawback would severely restrict the dendrite- inhibiting efficacy, especially under large mass loadings of active materials. Inspi...
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作者：Ferrarone, John R.; Thomas, Jerin; Unni, Arun M.; Zheng, Yuxiang; Nagiec, Michal J.; Gardner, Eric E.; Mashadova, Oksana; Li, Kate; Koundouros, Nikos; Montalbano, Antonino; Mustafa, Meer; Cantley, Lewis C.; Blenis, John; Sanjana, Neville E.; Varmus, Harold
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; New York University; Cornell University; Weill Cornell Medicine; Northwell Health; Hofstra University; Harvard University; Harvard Medical School; Regeneron; 23andMe, Inc.
摘要：The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell polarity and metabolism; however, the pathways that mediate the tumor - suppressive activity of LKB1 are incompletely defined. To identify mechanisms of LKB1mediated growth suppression, we developed a spheroid - based cell culture assay to study LKB1dependent growth. We then performed genome - wid...
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作者：Kauai, Felipe; Bafort, Quinten; Mortier, Frederik; Van Montagu, Marc; Bonte, Dries; Van de Peer, Yves
作者单位：Ghent University; Flanders Institute for Biotechnology (VIB); Ghent University; University of Pretoria; Nanjing Agricultural University
摘要：Hybridization blurs species boundaries and leads to intertwined lineages resulting in reticulate evolution. Polyploidy, the outcome of whole genome duplication (WGD), has more recently been implicated in promoting and facilitating hybridization between polyploid species, potentially leading to adaptive introgression. However, because polyploid lineages are usually ephemeral states in the evolutionary history of life it is unclear whether WGD - potentiated hybridization has any appreciable effe...
