2024

最新文章

• Half a century of quantitative cultural evolution AI翻译
  作者：Fogarty, Laurel; Kandler, Anne; Creanza, Nicole; Feldman, Marcus W.
  作者单位：Max Planck Society; Vanderbilt University; Stanford University
• Ribosomally derived lipopeptides containing distinct fatty acyl moieties (vol 119, e2113120119, 2022) AI翻译
  作者：Hubrich, Florian; Bosch, Nina M.; Chepkirui, Clara; Morinaka, Brandon I.; Rust, Michael; Gugger, Muriel; Robinson, Serina L.; Vagstad, Anna L.; Piel, Jorn
• Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits AI翻译
  作者：Pedroncini, Olivia; Federman, Noel; Marin-Burgin, Antonia
  作者单位：Max Planck Society; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Francis Crick Institute
  摘要：Odors are key signals for guiding spatial behaviors such as foraging and navigation in rodents. Recent findings reveal that odor representations in the piriform cortex (PCx) also encode spatial context information. However, the brain origins of this information and its integration into PCx microcircuitry remain unclear. This study investigates the lateral entorhinal cortex (LEC) as a potential source of spatial contextual information affecting the PCx microcircuit and its olfactory responses. ...
• Ultradeep O- GlcNAc proteomics reveals widespread O- GlcNAcylation on tyrosine residues of proteins AI翻译
  作者：Hou, Chunyan; Deng, Jingtao; Wu, Ci; Zhang, Jing; Byers, Stephen; Moremen, Kelley W.; Pei, Huadong; Ma, Junfeng
  作者单位：Georgetown University; University System of Georgia; Georgia State University; University System of Georgia; Georgia State University; University System of Georgia; University of Georgia
  摘要：As a unique type of glycosylation, O- linked beta-N- acetylglucosamine (O- GlcNAc) modification (O- GlcNAcylation) on Ser/Thr residues of proteins was discovered 40 y ago. O- GlcNAcylation is catalyzed by two enzymes: O- GlcNAc transferase (OGT) and O- GlcNAcase (OGA), which add and remove O- GlcNAc, respectively. O- GlcNAcylation is an essential glycosylation that regulates the functions of many proteins in virtually all cellular processes. However, deep and site- specific characterization of...
• Cotranscriptional splicing is required in the cold to produce COOLAIR isoforms that repress Arabidopsis FLC AI翻译
  作者：Long, Xiaogang; Cai, Yajun; Wang, Huamei; Liu, Yue; Huang, Xiaoyi; Xuan, Hua; Li, Wenjuan; Zhang, Xiaoling; Zhang, Hongya; Fang, Xiaofeng; He, Hang; Xu, Guoyong; Dean, Caroline; Yang, Hongchun
  作者单位：Wuhan University; Hubei Hongshan Laboratory; Peking University; Wuhan University; Wuhan University; Tsinghua University
  摘要：Plants use seasonal cold to time the transition to reproductive development. Shortand long- term cold exposure is registered via parallel transcriptional shutdown and Polycomb- dependent epigenetic silencing of the Arabidopsis thaliana major flowering repressor locus FLOWERING LOCUS C (FLC). The cold- induced antisense transcripts (COOLAIR) determine the dynamics of FLC transcriptional shutdown, but the thermosensory mechanisms are still unresolved. Here, through a forward genetic screen, we i...
• The structures of protein kinase A in complex with CFTR : Mechanisms of phosphorylation and noncatalytic activation AI翻译
  作者：Fiedorczuk, Karol; Iordanov, Iordan; Mihalyi, Csaba; Szollosi, Andras; Csanady, Laszlo; Chen, Jue
  作者单位：Rockefeller University; Semmelweis University; Semmelweis University; Howard Hughes Medical Institute
  摘要：Protein kinase A (PKA) is a key regulator of cellular functions by selectively phosphorylating numerous substrates, including ion channels, enzymes, and transcription factors. It has long served as a model system for understanding the eukaryotic kinases. Using cryoelectron microscopy, we present complex structures of the PKA catalytic subunit (PKA-C) bound to a full- length protein substrate, the cystic fibrosis transmembrane conductance regulator (CFTR)-an ion channel vital to human health. C...
• DeSide: A unified deep learning approach for cellular deconvolution of tumor microenvironment AI翻译
  作者：Xiong, Xin; Liu, Yerong; Pu, Dandan; Yang, Zhu; Bi, Zedong; Tian, Liang; Li, Xuefei
  作者单位：Hong Kong Baptist University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Hong Kong Baptist University; Lingang Laboratory; Hong Kong Baptist University; Hong Kong Baptist University
  摘要：Cellular deconvolution via bulk RNA sequencing (RNA-seq) presents a cost- effective and efficient alternative to experimental methods such as flow cytometry and single- cell RNA-seq (scRNA-seq) for analyzing the complex cellular composition of tumor microenvironments. Despite challenges due to heterogeneity within and among tumors, our innovative deep learning-based approach, DeSide, shows exceptional accuracy in estimating the proportions of 16 distinct cell types and subtypes within solid tu...
• SPATEs promote the survival of Shigella to the plasma complement system upon local hemorrhage and bacteremia AI翻译
  作者：Debande, Lorine; Sabbah, Ahmad; Kuhn, Lauriane; Ngondo, Richard Patry; Maucotel, Julie; Valente- Barroso, Marina; Andre, Antonin C.; Roche, Beatrice; Laborde, Matthieu; Cantalapiedra-Mateo, Maria- Victoria; Thahouly, Tamou; Milinski, Ana; Bianchetti, Laurent; Allmang, Christine; Frugier, Magali; Marteyn, Benoit S.
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg
  摘要：Shigella spp. are the causative agents of shigellosis, which remains a leading cause of death in children under the age of 5. Symptoms of shigellosis include bloody diarrhea, associated to colon hemorrhage; in more severe cases, Shigella bacteremia is induced. These clinical features indicate that Shigella are exposed and survive exposure to plasma, locally and systemically, although this has not yet been studied at a molecular level. In this report, we confirmed in a guinea pig model of shige...
• A receptor kinase senses sterol by coupling with elicitins in auxotrophic Phytophthora AI翻译
  作者：Pei, Yong; Ji, Peiyun; Miao, Jinlu; Gu, Xinyi; Wang, Hui; Zhao, Yaning; Song, Wen; Guo, Zhenjie; Zhou, Hao; Shen, Danyu; Liu, Jinding; Si, Jierui; Yan, Jianyu; Ren, Yingkai; Bao, Yazhou; Yin, Zhiyuan; Dou, Daolong
  作者单位：Nanjing Agricultural University; Nanjing Agricultural University
  摘要：Sterols are vital nutrients and signals for eukaryotic organisms. Mammalian cells are known to sense and respond to sterol status changes to maintain them within strict limits, a process associated with various human diseases. However, this process is not understood in oomycete pathogens, most of which are sterol auxotrophic and must obtain sterols from host plants. Here, we report that Phytophthora sojae SSRK1 (sterol- sensing receptor kinase 1) detects host sterols by coupling with elicitins...
• Differential neural mechanisms underlie cortical gating of visual spatial attention mediated by alpha- band oscillations AI翻译
  作者：Yang, Xiaofang; Fiebelkorn, Ian C.; Jensen, Ole; Knight, Robert T.; Kastner, Sabine
  作者单位：Princeton University; Princeton University; University of Rochester; University of Rochester; University of Oxford; University of Oxford; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Selective attention relies on neural mechanisms that facilitate processing of behaviorally relevant sensory information while suppressing irrelevant information, consistently linked to alpha- band oscillations in human M/EEG studies. We analyzed cortical alpha responses from intracranial electrodes implanted in eight epilepsy patients, who performed a visual spatial attention task. Electrocorticographic data revealed a spatiotemporal dissociation between attention- modulated alpha desynchroniz...