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作者：Doolittle, W. Ford
作者单位：Dalhousie University; Dalhousie University
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作者：Gu, Xiaosong; Feng, Xuezhen; Yang, Songhe; Wang, Ranhao; Zeng, Qiang; Shangguan, Yangzi; Liang, Jiaxin; Zhou, Huiling; Li, Zhiwei; Lin, Zhang; Zheng, Chunmiao; Xu, Zhenghe; Chen, Hong
作者单位：Southern University of Science & Technology; Central South University; Eastern Institute of Technology, Ningbo; Eastern Institute for Advanced Study; Southern University of Science & Technology
摘要：The insatiable demand for lithium in portable energy storage necessitates a sustainable and low- carbon approach to its recovery. Conventional hydrometallurgical and pyrometallurgical methods heavily involve hazardous chemicals and significant CO2 emissions. Herein, by integrating electrode oxidation with electrolyte oxidation, we establish a photovoltaic- driven dual- oxidation seawater electrolyzer system for low- carbon footprint and high lithium recovery. A 98.96% lithium leaching rate wit...
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作者：Gao, Jun; Yang, Jingyi; Dong, Hongzhe; Tao, Shaoyang; Shi, Jianbo; He, Bin; Bian, Xiqing; Wu, Jian-lin; Yin, Yongguang; Hu, Ligang; Jiang, Guibin
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Macau University of Science & Technology; Jianghan University
摘要：Methylmercury (MeHg) is a bioaccumulating neurotoxin mainly produced by anaerobic microorganisms, with methanogen being one of the important methylators. A critical aspect for understanding the mechanism for microbial mercury (Hg) methylation is the origin of the methyl group. However, the origin of methyl group in methanogen- mediated Hg methylation remains unclear. This study aims to identify the source of methyl group for MeHg synthesis in methanogens. Our study revealed that Hg methylation...
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作者：Hu, Yingjie; Lopez, Victor A.; Xu, Hengyi; Pfister, James P.; Song, Bing; Servage, Kelly A.; Sakurai, Masahiro; Jones, Benjamin T.; Mendell, Joshua T.; Wang, Tao; Wu, Jun; Lambowitz, Alan M.; Tomchick, Diana R.; Pawlowski, Krzysztof; Tagliabracci, Vincent S.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：ATP- grasp superfamily enzymes contain a hand- like ATP- binding fold and catalyze a variety of reactions using a similar catalytic mechanism. More than 30 protein families are categorized in this superfamily, and they are involved in a plethora of cellular processes and human diseases. Here, we identify C12orf29 (RLIG1) as an atypical ATP- grasp enzyme that ligates RNA. Human RLIG1 and its homologs autoadenylate on an active site Lys residue as part of a reaction intermediate that specificall...
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作者：Ortega-Ramirez, Audrey Magdalena; Albani, Simone; Bachmann, Michele; Schmidt, Axel; Pinoe, Manuela; Assmann, Marc; Augustinowski, Katrin; Rossetti, Giulia; Gruender, Stefan
作者单位：University of Bonn; University of Bonn; RWTH Aachen University; Helmholtz Association; Research Center Julich; Helmholtz Association; Research Center Julich; RWTH Aachen University
摘要：The only known peptide- gated ion channels-FaNaCs/WaNaCs and HyNaCs-belong to different clades of the DEG/ENaC family. FaNaCs are activated by the short neuropeptide FMRFamide, and HyNaCs by Hydra RFamides, which are not evolutionarily related to FMRFamide. The FMRFamide- binding site in FaNaCs was recently identified in a cleft atop the large extracellular domain. However, this cleft is not conserved in HyNaCs. Here, we combined molecular modeling and site- directed mutagenesis and identified...
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作者：Smart, Matthew; Shvartsman, Stanislav Y.; Gershman, Samuel J.
作者单位：Simons Foundation; Flatiron Institute; Princeton University; Princeton University; Ruhr University Bochum
摘要：Habituation-a phenomenon in which a dynamical system exhibits a diminishing response to repeated stimulations that eventually recovers when the stimulus is withheld-is universally observed in living systems from animals to unicellular organisms. Despite its prevalence, generic mechanisms for this fundamental form of learning remain poorly defined. Drawing inspiration from prior work on systems that respond adaptively to step inputs, we study habituation from a nonlinear dynamics perspective. T...
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作者：Gao, Mu; Skolnick, Jeffrey
作者单位：University System of Georgia; Georgia Institute of Technology
摘要：Identifying antibodies that neutralize specific antigens is crucial for developing effective immunotherapies, but this task remains challenging for many target antigens. The rise of deep learning-based computational approaches presents a promising avenue to address this challenge. Here, we assess the performance of a deep learning approach through two benchmark tests aimed at predicting antibodies for the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
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作者：Gadea, Esteban D.; Sirkin, Yamila A. Perez; Molinero, Valeria; Scherlis, Damian A.
作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Utah System of Higher Education; University of Utah
摘要：Many of the relevant electrochemical processes in the context of catalysis or energy conversion and storage, entail the production of gases. This often implicates the nucleation of bubbles at the interface, with the concomitant blockage of the electroactive area leading to overpotentials and Ohmic drop. Nanoelectrodes have been envisioned as assets to revert this effect, by inhibiting bubble formation. Experiments show, however, that nanobubbles nucleate and attach to nanoscale electrodes, imp...
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作者：Bartolucci, Silvia; Caccioli, Fabio; Caravelli, Francesco; Vivo, Pierpaolo
作者单位：University of London; University College London; Imperial College London; University of London; London School Economics & Political Science; United States Department of Energy (DOE); Los Alamos National Laboratory; University of London; King's College London
摘要：The Katz centrality of a node in a complex network is a measure of the node's importance as far as the flow of information across the network is concerned. For ensembles of locally tree-like undirected random graphs, this observable is a random variable. Its full probability distribution is of interest but difficult to handle analytically because of its global character and its definition in terms of a matrix inverse. Leveraging a fast Gaussian Belief Propagation-Cavity algorithm to solve line...
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作者：Curtis, Zachary; Escudeiro, Pedro; Mallon, John; Leland, Olivia; Rados, Theopi; Dodge, Ashley; Andre, Katherine; Kwak, Jasmin; Yun, Kun; Isaac, Berith; Pastor, Mar Martinez; Schmid, Amy K.; Pohlschroder, Mechthild; Alva, Vikram; Bisson, Alex
作者单位：Brandeis University; University of Pennsylvania; Duke University
摘要：Bactofilins are rigid, nonpolar bacterial cytoskeletal filaments that link cellular processes to specific curvatures of the cytoplasmic membrane. Although homologs of bactofilins have been identified in archaea and eukaryotes, functional studies have remained confined to bacterial systems. Here, we characterize representatives of two families of archaeal bactofilins from the pleomorphic archaeon Haloferax volcanii, halofilin A straight bundles. HalA polymers are highly dynamic and accumulate a...
