2024

最新文章

• Advantage of an epigenetic switch in response to alternate environments AI翻译
  作者：Low, David
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
• In situ electrogenerated Cu(III) triggers hydroxyl radical production on the Cu-Sb-SnO2 electrode for highly efficient water decontamination (vol 120, e2306835120, 2023) AI翻译
  作者：Lu, Sen; Li, Xuechuan; Cheng, Yumeng; Zhou, Jia; Zhang, Guan
• Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis AI翻译
  作者：Lopes, Filipa L.; Jordan, Pau Formosa; Malivert, Alice; Margalha, Leonor; Confraria, Ana; Feil, Regina; Lunn, John E.; Jonsson, Henrik; Landrein, Benoit; Baena-Gonzalez, Elena
  作者单位：Instituto Gulbenkian de Ciencia; Universidade Nova de Lisboa; University of Cambridge; University of Oxford; Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; INRAE; Max Planck Society; University of Cambridge; Lund University
  摘要：In plants, development of all above- ground tissues relies on the shoot apical meristem (SAM) which balances cell proliferation and differentiation to allow life- long growth. To maximize fitness and survival, meristem activity is adjusted to the prevailing conditions through a poorly understood integration of developmental signals with environmental and nutritional information. Here, we show that sugar signals influence SAM function by altering the protein levels of SHOOT MERISTEMLESS (STM), ...
• An integrated transcription factor framework for Treg identity and diversity AI翻译
  作者：Chowdhary, Kaitavjeet; Leon, Juliette; Mathis, Diane; Benoist, Christophe
  作者单位：Harvard University; Harvard Medical School; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Vertebrate cell identity depends on the combined activity of scores of transcription factors (TF). While TFs have often been studied in isolation, a systematic perspective on their integration has been missing. Focusing on FoxP3+ regulatory T cells (Tregs), key guardians of immune tolerance, we combined single- cell chromatin accessibility, machine learning, and high- density genetic variation, to resolve a validated framework of diverse Treg chromatin programs, each shaped by multi-TF inputs....
• Type I interferon signaling pathway enhances immune- checkpoint inhibition in KRAS mutant lung tumors AI翻译
  作者：Fernandez-Garcia, Fernando; Fernandez-Rodriguez, Ana; Fustero-Torre, Coral; Pineiro-Yanez, Elena; Wang, Haiyun; Lechuga, Carmen G.; Callejas, Sergio; Alvarez, Rebeca; Lopez-Garcia, Alejandra; Esteban-Burgos, Laura; Salmon, Marina; San Roman, Marta; Guerra, Carmen; Ambrogio, Chiara; Drosten, Matthias; Santamaria, David; Al Shahrour, Fatima; Dopazo, Ana; Barbacid, Mariano; Musteanu, Monica
  作者单位：Tongji University; Centro Nacional de Investigaciones Cardiovasculares (CNIC); Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; University of Turin; Consejo Superior de Investigaciones Cientificas (CSIC); University of Salamanca; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; Complutense University of Madrid; Helmholtz Association; Max Delbruck Center for Molecular Medicine
  摘要：Lung cancer is the leading cause of cancer mortality worldwide. KRAS oncogenes are responsible for at least a quarter of lung adenocarcinomas, the main subtype of lung cancer. After four decades of intense research, selective inhibitors of KRAS oncoproteins are finally reaching the clinic. Yet, their effect on overall survival is limited due to the rapid appearance of drug resistance, a likely consequence of the high intratumoral heterogeneity characteristic of these tumors. In this study, we ...
• Lactobacillus Firm-5-derived succinate prevents honeybees from having diabetes- like symptoms AI翻译
  作者：Han, Benfeng; Hu, Jiawei; Yang, Chengfeng; Tang, Junbo; Du, Yating; Guo, Lizhen; Wu, Yashuai; Zhang, Xue; Zhou, Xin
  作者单位：China Agricultural University; China Agricultural University; China Agricultural University; China Agricultural University
  摘要：The gut microbiome plays an important role in honeybee hormonal regulation and growth, but the underlying mechanisms are poorly understood. Here, we showed that the depletion of gut bacteria resulted in reduced expression of insulin- like peptide gene (ilp) in the head, accompanied by metabolic syndromes resembling those of Type 1 diabetes in humans: hyperglycemia, impaired lipid storage, and decreased metabolism. These symptoms were alleviated by gut bacterial inoculation. Gut metabolite prof...
• Command of three- dimensional solitary waves via photopatterning AI翻译
  作者：Li, Chao-Yi; Tang, Xing- Zhou; Yu, Xiao; Atzin, Noe; Song, Zhen- Peng; Chen, Chu- Qiao; Abbott, Nicholas L.; Li, Bing- Xiang; de Pablo, Juan J.; Lu, Yan-Qing
  作者单位：Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Nanjing University of Posts & Telecommunications; Nanjing University of Posts & Telecommunications; University of Chicago; Cornell University; United States Department of Energy (DOE); Argonne National Laboratory
  摘要：Multidimensional solitons are prevalent in numerous research fields. In orientationally ordered soft matter system, three- dimensional director solitons exemplify the localized distortion of molecular orientation. However, their precise manipulation remains challenging due to unpredictable and uncontrolled generation. Here, we utilize preimposed programmable photopatterning in nematics to control the kinetics of director solitons. This enables both unidirectional and bidirectional generation a...
• Prevotella are major contributors of sialidases in the human vaginal microbiome AI翻译
  作者：Pelayo, Paula; Hussain, Fatima A.; Werlang, Caroline A.; Wu, Chloe M.; Woolston, Benjamin M.; Xiang, Claire M.; Rutt, Lindsay; France, Michael T.; Ravel, Jacques; Ribbeck, Katharina; Kwon, Douglas S.; Balskus, Emily P.
  作者单位：Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Ragon Institute; Massachusetts Institute of Technology (MIT); Northeastern University; University System of Maryland; University of Maryland Baltimore; Harvard University; Howard Hughes Medical Institute
  摘要：Elevated bacterial sialidase activity in the female genital tract is strongly associated with poor health outcomes including preterm birth and bacterial vaginosis (BV). These negative effects may arise from sialidase- mediated degradation of the protective mucus layer in the cervicovaginal environment. Prior biochemical studies of vaginal bacterial sialidases have focused solely on the BV- associated organism Gardnerella vaginalis. Despite their implications for sexual and reproductive health,...
• Synonymous codon substitutions modulate transcription and translation of a divergent upstream gene by modulating antisense RNA production AI翻译
  作者：Rodriguez, Anabel; Diehl, Jacob D.; Wright, Gabriel S.; Bonar, Christopher D.; Lundgren, Taylor J.; Moss, McKenze J.; Li, Jun; Milenkovic, Tijana; Huber, Paul W.; Champion, Matthew M.; Emrich, Scott J.; Clark, Patricia L.
  作者单位：Milwaukee School Engineering
  摘要：Synonymous codons were originally viewed as interchangeable, with no phenotypic consequences. However, substantial evidence has now demonstrated that synonymous substitutions can perturb a variety of gene expression and protein homeostasis mechanisms, including translational efficiency, translational fidelity, and cotranslational folding of the encoded protein. To date, most studies of synonymous codon-derived perturbations have focused on effects within a single gene. Here, we show that synon...
• Increasing environmental variability inhibits evolutionary rescue in a long- lived vertebrate AI翻译
  作者：Clark-Wolf, T. J.; Boersma, P. Dee; Plard, Floriane; Rebstock, Ginger A.; Abrahms, Briana
  作者单位：University of Washington; University of Washington Seattle; Utah System of Higher Education; Utah State University
  摘要：Evolutionary rescue, whereby adaptive evolutionary change rescues populations from extinction, is theorized to enable imperiled animal populations to persist under increasing anthropogenic change. Despite a large body of evidence in theoretical and laboratory settings, the potential for evolutionary rescue to be a viable adaptation process for free- ranging animals remains unknown. Here, we leverage a 38- year dataset following the fates of 53,959 Magellanic penguins ( Spheniscus magellanicus)...