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作者：Huang, Zitong; Zhang, Yuan; Wang, Shoupeng; Qi, Renfei; Sun, Yufang; Tao, Yu; Jiang, Dongsheng; Jiang, Xinghong; Tao, Jin
作者单位：Soochow University - China; Soochow University - China; Soochow University - China; Soochow University - China; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Soochow University - China
摘要：The N6- methyladenosine (m6A) modification of RNA is an emerging epigenetic regulatory mechanism that has been shown to participate in various pathophysiological processes. However, its involvement in modulating neuropathic pain is still poorly understood. In this study, we elucidate a functional role of the m6A demethylase alkylation repair homolog 5 (ALKBH5) in modulating trigeminal- mediated neuropathic pain. Peripheral nerve injury selectively upregulated the expression level of ALKBH5 in ...
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作者：Kim, Khwan; Askin, Noah; Evans, James A.
作者单位：INSEAD Business School; University of California System; University of California Irvine; University of Chicago; University of Chicago
摘要：Understanding and predicting the emergence and evolution of cultural tastes manifested in consumption patterns is of central interest to social scientists, analysts of culture, and purveyors of content. Prior research suggests that taste preferences relate to personality traits, values, shifts in mood, and immigration destination. Understanding everyday patterns of listening and the function music plays in life has remained elusive, however, despite speculation that musical nostalgia may compe...
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作者：Baghdasaryan, Ani; Liu, Haoran; Ren, Fuqiang; Hsu, RuSiou; Jiang, Yingying; Wang, Feifei; Zhang, Mengzhen; Grigoryan, Lilit; Dai, Hongjie
作者单位：Stanford University; Stanford University
摘要：Surgical resections of solid tumors guided by visual inspection of tumor margins have been performed for over a century to treat cancer. Near-infrared (NIR) fluorescence labeling/imaging of tumor in the NIR-I (800 to 900 nm) range with systemically administrated fluorophore/tumor-targeting antibody conjugates have been introduced to improve tumor margin delineation, tumor removal accuracy, and patient survival. Here, we show Au25 molecular clusters functionalized with phosphorylcholine ligands...
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作者：Ren, Lingxiao; Hu, Zhenglin; Peng, Chengxin; Zhang, Lan; Wang, Nan; Wang, Fei; Xia, Yongyao; Zhang, Suojiang; Hu, Enyuan; Luo, Jiayan
作者单位：Shanghai Jiao Tong University; Tianjin University; University of Shanghai for Science & Technology; Institute of Process Engineering, CAS; Chinese Academy of Sciences; United States Department of Energy (DOE); Brookhaven National Laboratory; Fudan University; Fudan University; Shanghai Jiao Tong University
摘要：Direct use of metals as battery anodes could significantly boost the energy density, but suffers from limited cycling. To make the batteries more sustainable, one strategy is mitigating the propensity for metals to form random morphology during plating through orientation regulation, e.g., hexagonal Zn platelets locked horizontally by epitaxial electrodeposition or vertically aligned through Zn/electrolyte interface modulation. Current strategies center around obtaining (002) faceted depositio...
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作者：Rockstroem, Johan; Kotze, Louis; Milutinovic, Svetlana; Biermann, Frank; Brovkin, Victor; Donges, Jonathan; Ebbesson, Jonas; French, Duncan; Gupta, Joyeeta; Kim, Rakhyun; Lenton, Timothy; Lenzi, Dominic; Nakicenovic, Nebojsa; Neumann, Barbara; Schuppert, Fabian; Winkelmann, Ricarda; Bosselmann, Klaus; Folke, Carl; Lucht, Wolfgang; Schlosberg, David; Richardson, Katherine; Steffen, Will
作者单位：Potsdam Institut fur Klimafolgenforschung; University of Potsdam; Stockholm University; North West University - South Africa; University of Lincoln; Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences; Utrecht University; Max Planck Society; Stockholm University; University of Lincoln; University of Amsterdam; IHE Delft Institute for Water Education; University of Exeter; University of Twente; International Institute for Applied Systems Analysis (IIASA); Technische Universitat Wien; Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences; University of Potsdam; Max Planck Society; University of Auckland; Royal Swedish Academy of Sciences; Beijer Institute of Ecological Economics; Humboldt University of Berlin; University of Sydney; University of Copenhagen; Australian National University
摘要：The Anthropocene signifies the start of a no- analogue tra-jectory of the Earth system that is fundamentally different from the Holocene. This new trajectory is characterized by rising risks of triggering irreversible and unmanageable shifts in Earth system functioning. We urgently need a new global approach to safeguard critical Earth system regulating functions more effectively and comprehensively. The global commons framework is the closest example of an existing approach with the aim of go...
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作者：Long, Chengyi; Deng, Jie; Nguyen, Jen; Liu, Yang-Yu; Alm, Eric J.; Sole, Ricard; Saavedra, Serguei
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Illinois System; University of Illinois Urbana-Champaign; Pompeu Fabra University; ICREA; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; The Santa Fe Institute
摘要：communities on the current taxon membership, enhancing the switching capacity of microbial systems. Following a structuralist approach, we propose that each community is feasible within a unique domain in environmental parameter space. Then, structured transitions between any two communities can happen with probability proportional to the size of their feasibility domains and inversely proportional to their distance in environmental parameter space-which can be treated as a special case of the...
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作者：Jarillo, Sergio; Barnett, Jon
作者单位：University of Melbourne
摘要：Climate change might catalyze and exacerbate the trend of outmigration from low-lying atoll islands. There is speculation that migration away from atolls may not stop until such islands are abandoned. Yet migration creates both opportunities and risks for the sustainability of atoll communities. There is a trade-off between reduced demographic pressure on increasingly fragile atoll island environments and the financial and human resources necessary to adapt to climate change that can result fr...
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作者：Yuan, Youwen; Li, Kangli; Ye, Xueru; Wen, Shiyi; Zhang, Yanan; Teng, Fei; Zhou, Xuan; Deng, Yajuan; Yang, Xiaoyu; Wang, Weiwei; Lin, Jiayang; Luo, Shenjian; Zhang, Peizhen; Shi, Guojun; Zhang, Huijie
作者单位：Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Army Medical University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
摘要：Brown adipose tissue (BAT) is the main site of nonshivering thermogenesis which plays an important role in thermogenesis and energy metabolism. However, the regulatory factors that inhibit BAT activity remain largely unknown. Here, cardiotrophin-like cytokine factor 1 (CLCF1) is identified as a negative regulator of thermogenesis in BAT. Adenovirus-mediated overexpression of CLCF1 in BAT greatly impairs the thermogenic capacity of BAT and reduces the metabolic rate. Consistently, BAT-specific ...
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作者：Cui, Mengying; Yamano, Koji; Yamamoto, Kenichi; Yamamoto-Imoto, Hitomi; Minami, Satoshi; Yamamoto, Takeshi; Matsui, Sho; Kaminishi, Tatsuya; Shima, Takayuki; Ogura, Monami; Tsuchiya, Megumi; Nishino, Kohei; Layden, Brian T.; Kato, Hisakazu; Ogawa, Hidesato; Oki, Shinya; Okada, Yukinori; Isaka, Yoshitaka; Kosako, Hidetaka; Matsuda, Noriyuki; Yoshimori, Tamotsu; Nakamura, Shuhei
作者单位：University of Osaka; Tokyo Metropolitan Institute of Medical Science; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); University of Osaka; University of Osaka; University of Osaka; University of Osaka; Nara Medical University; University of Osaka; University of Osaka; Tokushima University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center; University of Osaka; Kyoto University; University of Osaka
摘要：Mitochondrial and lysosomal functions are intimately linked and are critical for cellular homeostasis, as evidenced by the fact that cellular senescence, aging, and multiple prominent diseases are associated with concomitant dysfunction of both organelles. However, it is not well understood how the two important organelles are regulated. Transcription factor EB (TFEB) is the master regulator of lysosomal function and is also implicated in regulating mitochondrial function; however, the mechani...
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作者：Moore, Emily J.; Karplus, Valerie J.; Morgan, M. Granger
作者单位：Carnegie Mellon University
摘要：Many studies anticipate that carbon capture and sequestration (CCS) will be essential to decarbonizing the U.S. economy. However, prior work has not estimated the time required to develop, approve, and implement a geologic sequestration site in the United States. We generate such an estimate by identifying six clearance points that must be passed before a sequestration site can become operational. For each clearance point (CP), we elicit expert judgments of the time required in the form of pro...
