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作者：Beveridge, Claire F.; Espinoza, Jhan-Carlo; Athayde, Simone; Correa, Sandra Bibiana; Couto, Thiago B. A.; Heilpern, Sebastian A.; Jenkins, Clinton N.; Piland, Natalia C.; Utsunomiya, Renata; Wongchuig, Sly; Anderson, Elizabeth P.
作者单位：State University System of Florida; Florida International University; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Institut de Recherche pour le Developpement (IRD); Pontificia Universidad Catolica del Peru; State University System of Florida; Florida International University; State University System of Florida; Florida International University; Mississippi State University; Lancaster University; Cornell University; Universidade de Sao Paulo; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Laboratoire d'Etudes en Geophysique et oceanographie spatiales; Cornell University
摘要：The Amazon River Basin's extraordinary social-ecological system is sustained by various water phases, fluxes, and stores that are interconnected across the tropical Andes mountains, Amazon lowlands, and Atlantic Ocean. This Andes-Amazon- Atlantic (AAA) pathway is a complex hydroclimatic system linked by the regional water cycle through atmospheric cir - culation and continental hydrology. Here, we aim to articu - late the AAA hydroclimate pathway as a foundational system for research, manageme...
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作者：Casden, Natania; Belzer, Vitali; El Khayari, Abdellatif; El Fatimy, Rachid; Behar, Oded
作者单位：Hebrew University of Jerusalem; Mohammed VI Polytechnic University
摘要：After central nervous system injury, a rapid cellular and molecular response is induced. This response can be both beneficial and detrimental to neuronal survival in the first few days and increases the risk for neurodegeneration if persistent. Semaphorin4B (Sema4B), a transmembrane protein primarily expressed by cortical astrocytes, has been shown to play a role in neuronal cell death following injury. Our study shows that after cortical stab wound injury, cytokine expression is attenuated in...
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作者：Gahlot, Shivani; Singh, Jogender
作者单位：Indian Institute of Science Education & Research (IISER) - Mohali
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作者：Del Tatto, Vittorio; Fortunato, Gianfranco; Bueti, Domenica; Laio, Alessandro
作者单位：International School for Advanced Studies (SISSA); Abdus Salam International Centre for Theoretical Physics (ICTP)
摘要：We introduce an approach which allows detecting causal relationships between variables for which the time evolution is available. Causality is assessed by a variational scheme based on the Information Imbalance of distance ranks, a statistical test capable of inferring the relative information content of different distance measures. We test whether the predictability of a putative driven system Y can be improved by incorporating information from a potential driver system X, without explicitly ...
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作者：Gabrielsen, Paul
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作者：Katerndahl, Casey D. S.; Rogers, Olivia R. S.; Day, Ryan B.; Xu, Ziheng; Helton, Nichole M.; Ramakrishnan, Sai Mukund; Miller, Christopher A.; Ley, Timothy J.
作者单位：Washington University (WUSTL)
摘要：The underlying mechanism(s) by which the PML::RARA fusion protein initiates acute promyelocytic leukemia is not yet clear. We defined the genomic binding sites of PML::RARA in primary mouse and human hematopoietic progenitor cells with V5-tagged PML::RARA, using anti-V5-PML::RARA chromatin immunoprecipitation sequencing and CUT&RUN approaches. Most genomic PML::RARA binding sites were found in regions that were already chromatin-accessible (defined by ATAC-seq) in unmanipulated, wild-type prom...
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作者：Senyuk, Bohdan; Wu, Jin-Sheng; Smalyukh, Ivan I.
作者单位：University of Colorado System; University of Colorado Boulder; Hiroshima University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要：Many living and artificial systems show similar emergent behavior and collective motions on different scales, starting from swarms of bacteria to synthetic active particles, herds of mammals, and crowds of people. What all these systems often have in common is that new collective properties like flocking emerge from interactions between individual self-propelled or driven units. Such systems are naturally out-of-equilibrium and propel at the expense of consumed energy. Mimicking nature by maki...
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作者：Galloni, Alessandro R.; Yuan, Yifan; Zhu, Minning; Yu, Haoming; Bisht, Ravindra S.; Wu, Chung-Tse Michael; Grienberger, Christine; Ramanathan, Shriram; Milstein, Aaron D.
作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Purdue University System; Purdue University; Brandeis University; Brandeis University; Brandeis University
摘要：Design of hardware based on biological principles of neuronal computation and plasticity in the brain is a leading approach to realizing energy- and sample- efficient AI and learning machines. An important factor in selection of the hardware building blocks is the identification of candidate materials with physical properties suitable to emulate the large dynamic ranges and varied timescales of neuronal signaling. Previous work has shown that the all- or- none spiking behavior of neurons can b...
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作者：Gu, Lijie; Du, Yanhong; Chen, Jianglei; Hasan, Mohammad Nazmul; Clayton, Yung Dai; Matye, David J.; Friedman, Jacob E.; Li, Tiangang
作者单位：University of Oklahoma System; University of Oklahoma Health Sciences Center
摘要：Cullin RING E3 ligases (CRL) have emerged as key regulators of disease - modifying pathways and therapeutic targets. Cullin3 (Cul3) - containing CRL (CRL3) has been implicated in regulating hepatic insulin and oxidative stress signaling. However, CRL3 function in liver pathophysiology is poorly defined. Here, we report that hepatocyte Cul3 knockout results in rapid resolution of steatosis in obese mice. However, the remarkable resistance of hepatocyte Cul3 knockout mice to developing steatosis...
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作者：Hellsberg, Eva; Boytsov, Danila; Chen, Qingyang; Niello, Marco; Freissmuth, Michael; Rudnick, Gary; Zhang, Yuan-Wei; Sandtner, Walter; Forrest, Lucy R.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Medical University of Vienna; Guangzhou University; Yale University
摘要：Clearance of serotonin (5 - hydroxytryptamine, 5 - HT) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter (SERT), which couples this process to the movement of a Na + ion down its chemical gradient. After release of 5 - HT and Na + into the cytoplasm, the transporter faces a rate - limiting challenge of resetting its conformation to be primed again for 5 - HT and Na + binding. Early studies of vesicles containing native SERT revealed that K + gradients can pr...
