2024

最新文章

• Breathing orchestrates synchronization of sleep oscillations in the human hippocampus AI翻译
  作者：Sheriff, Andrew; Zhou, Guangyu; Sagar, Vivek; Morgenthaler, Justin B.; Cyr, Christopher; Hauner, Katherina K.; Omidbeigi, Mahmoud; Rosenow, Joshua M.; Schuele, Stephan U.; Lane, Gregory; Zelano, Christina
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine
  摘要：Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory- driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate s...
• Growth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity AI翻译
  作者：Tavares, Mariana R.; dos Santos, Willian O.; Amaral, Andressa G.; List, Edward O.; Kopchick, John J.; Alves, Guilherme A.; Frazao, Renata; dos Santos, Jessica D. M.; Cruz, Alessandra G.; Camporez, Joao Paulo; Donato Jr, Jose
  作者单位：Universidade de Sao Paulo; Institute Biomed Science, University Sao Paulo; University System of Ohio; Ohio University; University System of Ohio; Ohio University; Universidade de Sao Paulo; Institute Biomed Science, University Sao Paulo; Universidade de Sao Paulo
  摘要：Growth hormone (GH) has several metabolic effects, including a profound impact on glucose homeostasis. For example, GH oversecretion induces insulin resistance and increases the risk of developing diabetes mellitus. Here, we show that GH receptor (GHR) ablation in vesicular glutamate transporter 2 (VGLUT2)- expressing cells, which comprise a subgroup of glutamatergic neurons, led to a slight decrease in lean body mass without inducing changes in body adiposity. VGLUT2 triangle GHR mice exhibit...
• Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells AI翻译
  作者：Yang, Jiao; Dan, Jiameng; Zhao, Nannan; Liu, Linlin; Wang, Huasong; Liu, Qiangqiang; Wang, Lingling; Li, Jie; Wu, Yiwei; Chen, Feilong; Fu, Weilun; Liu, Fei; Lin, Meiqi; Zhang, Weiyu; Chen, Fuquan; Liu, Xinqi; Lu, Xinyi; Chen, Quan; Wu, Xudong; Niu, Yuyu; Yang, Na; Zhu, Yushan; Long, Jiafu; Liu, Lin
  作者单位：Nankai University; Nankai University; Kunming University of Science & Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Nankai University; Nankai University; Tianjin Medical University; Nankai University
  摘要：Zygotic genome activation occurs in two-cell (2C) embryos, and a 2C-like state is also activated in sporadic (similar to 1%) naive embryonic stem cells in mice. Elevated chromatin accessibility is critical for the 2C-like state to occur, yet the underlying molecular mechanisms remain elusive. Zscan4 exhibits burst expression in 2C embryos and 2C-like cells. Here, we show that Zscan4 mediates chromatin remodeling to promote the chromatin accessibility for achieving the 2C-like state. Through co...
• The shard test and nanoporomechanics reverse classical paradigm of cement hydration being contractive AI翻译
  作者：Rosa, Raul E. Marrero; Bhibho, Tapiwanashe; Donmez, Ahmet A.; Cusatis, Gianluca; Bazant, Zdenek P.
  作者单位：Northwestern University
  摘要：Le Chatelier in 1887 and Powers in 1947 demonstrated that the volume of nanoscale C-S-H (calcium silicate hydrate) particles formed during hydration is smaller than the combined volume of the reactants-the anhydrous Portland cement and water. Hydration has thus been considered as contractive. An experiment shows that the opposite is true above the nanoscale. The porous skeleton of cement paste expands as the growing C-S-H particles push each other apart, similar to crystal growth pressure. Thi...
• Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2 AI翻译
  作者：Xu, Jiuyin; Xu, Youwei; Hou, Li; He, Xinheng; Li, Yang; Zhao, Jing; Meng, Xue; Wang, James Jiqi; Wu, Yanli; Zhang, Heng; Li, Yunhai; Hu, Wen; Yuan, Qingning; Wu, Kai; Cheng, Xi; Jiang, Yi; Xia, Yu; Xu, H. Eric; Wu, Canrong
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; ShanghaiTech University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanjing University of Chinese Medicine; Tsinghua University; Huazhong University of Science & Technology; Xiamen University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Lingang Laboratory
  摘要：Prostaglandin D2 receptor 2 (DP2) is an important anti- inflammatory and antiallergic drug target. While inactive DP2 structures are known, its activation mechanisms and biased signaling remain unclear. Here, we report cryo-EM structures of an apo DP2-Gi complex, a DP2-Gi complex bound to the endogenous ligand Prostaglandin D2 (PGD2), and a DP2-Gi complex bound to indomethacin, an arrestin- biased ligand, at resolutions of 2.5 & Aring;, 2.8 & Aring;, and 2.3 & Aring;, respectively. These struc...
• Structural stability and thermodynamics of artistic composition AI翻译
  作者：Chan, San To; Fried, Eliot
  作者单位：Okinawa Institute of Science & Technology Graduate University
  摘要：Inspired by the way that digital artists zoom out of the canvas to assess the visual impact of their works, we introduce a conceptually simple yet effective metric for quantifying the clarity of digital images. This metric contrasts original images with progressively melted counterparts, produced by randomly flipping adjacent pixel pairs. It measures the presence of stable structures, assigning the value zero to completely uniform or random images and finite values for those with discernible p...
• Magnetochrome- catalyzed oxidation of ferrous iron by MamP enables magnetite crystal growth in the magnetotactic bacterium AMB-1 AI翻译
  作者：Amor, Matthieu; Chevrier, Daniel M.; Siponen, Marina I.; Egli, Ramon; Scoppola, Ernesto; Marcano, Lourdes; Li, Chenghao; Choueikani, Fadi; Faivre, Damien
  作者单位：CEA; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Max Planck Society; CIC biomaGUNE; University of Oviedo; SOLEIL Synchrotron
  摘要：Magnetotactic bacteria have evolved the remarkable capacity to biomineralize chains of magnetite [Fe(II)Fe(III)2O4] nanoparticles that align along the geomagnetic field and optimize their navigation in the environment. Mechanisms enabling magnetite formation require the complex action of numerous proteins for iron acquisition, sequestration in dedicated magnetosome organelles, and precipitation into magnetite. The MamP protein contains c- type cytochromes called magnetochrome domains that are ...
• Alternative splicing of Clock transcript mediates the response of circadian clocks to temperature changes AI翻译
  作者：Cai, Yao D.; Liu, Xianhui; Chow, Gary K.; Hidalgo, Sergio; Jackson, Kiya C.; Vasquez, Cameron D.; Gao, Zita Y.; Lam, Vu H.; Tabuloc, Christine A.; Zheng, Haiyan; Zhao, Caifeng; Chiu, Joanna C.
  作者单位：University of California System; University of California Davis; Soochow University - China; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
  摘要：Circadian clocks respond to temperature changes over the calendar year, allowing organisms to adjust their daily biological rhythms to optimize health and fitness. In Drosophila, seasonal adaptations are regulated by temperature- sensitive alternative splicing (AS) of period (per) and timeless (tim) genes that encode key transcriptional repressors of clock gene expression. Although Clock (Clk) gene encodes the critical activator of circadian gene expression, AS of its transcripts and its poten...
• Behavioral interventions to motivate plant- based food selection in an online shopping environment AI翻译
  作者：Katare, Bhagyashree; Zhao, Shuoli
  作者单位：Purdue University System; Purdue University; University of Kentucky
  摘要：Encouraging consumption of plant- based food products can help mitigate the impact of dietary choices on climate change. Research suggests that modifying environments in which people make purchasing decisions has the potential to achieve behavioral changes toward sustainable consumption. We examine the impact of two behavioral interventions, carbon footprint labeling, and product categorization, to promote sustainable food selection in an online grocery shopping environment. Online grocery sho...
• Recurrent DNA nicks drive massive expansions of (GAA)n repeats AI翻译
  作者：Li, Liangzi; Scott, W. Shem; Khristich, Alexandra N.; Armenia, Jillian F.; Mirkin, Sergei M.
  作者单位：Tufts University; Stanford University; Vanderbilt University
  摘要：Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA)n repeat expansions are responsible for Friedreich's ataxia as well as late- onset cerebellar ataxias (LOCAs). Thus, the mechanisms of (GAA)n repeat expansions attract broad scientific attention. To investigate the role of DNA nicks in this process, we utilized a CRISPR-Cas9 nickase system to introduce targeted nicks adjacent to the (GAA)n repeat tract. We found that DNA nicks 5 ' of the...