2024

最新文章

• Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5catalyzed desuccinylation orchestrates antiviral innate immunity AI翻译
  作者：Liu, Xing; Zhu, Chunchun; Jia, Shuke; Deng, Hongyan; Tang, Jinhua; Sun, Xueyi; Zeng, Xiaoli; Chen, Xiaoyun; Wang, Zixuan; Liao, Qian; Liu, Wen; Zha, Huangyuan; Cai, Xiaolian; Xiao, Wuhan
  作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Hubei Hongshan Laboratory; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：To effectively protect the host from viral infection while avoiding excessive immunopathology, the innate immune response must be tightly controlled. However, the precise regulation of antiviral innate immunity and the underlying mechanisms remain unclear. Here, we find that sirtuin3 (SIRT3) interacts with mitochondrial antiviral signaling protein (MAVS) to catalyze MAVS deacetylation at lysine residue 7 (K7), which promotes MAVS aggregation, as well as TANK - binding kinase I and IRF3 phospho...
• Proof- of- concept studies with a computationally designed Mpro inhibitor as a synergistic combination regimen alternative to Paxlovid AI翻译
  作者：Papini, Christina; Ullah, Irfan; Ranjan, Amalendu P.; Zhang, Shuo; Wu, Qihao; Spasov, Krasimir A.; Zhang, Chunhui; Mothes, Walther; Crawford, Jason M.; Lindenbach, Brett D.; Uchil, Pradeep D.; Kumar, Priti; Jorgensen, William L.; Anderson, Karen S.
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：As the SARSCoV - 2 virus continues to spread and mutate, it remains important to focus not only on preventing spread through vaccination but also on treating infection with direct - acting antivirals (DAA). The approval of Paxlovid, a SARSCoV - 2 main protease (M pro ) DAA, has been significant for treatment of patients. A limitation of this DAA, however, is that the antiviral component, nirmatrelvir, is rapidly metabolized and requires inclusion of a CYP450 3A4 metabolic inhibitor, ritonavir,...
• PurA is the main target of aurodox, a type III secretion system inhibitor AI翻译
  作者：Watanabe, Yoshihiro; Haneda, Takeshi; Kimishima, Aoi; Kuwae, Asaomi; Suga, Takuya; Suzuki, Takahiro; Iwabuchi, Yoshiharu; Honsho, Masako; Honma, Sota; Iwatsuki, Masato; Matsui, Hidehito; Hanaki, Hideaki; Kanoh, Naoki; Abe, Akio; Asami, Yukihiro; Omura, Satoshi
  作者单位：Kitasato University; Kitasato University; Kitasato University; Tohoku University; Hoshi University; Hoshi University
  摘要：Anti - microbial resistance (AMR) is one of the greatest threats to global health. The continual battle between the emergence of AMR and the development of drugs will be extremely difficult to stop as long as traditional anti - biotic approaches are taken. In order to overcome this impasse, we here focused on the type III secretion system (T3SS), which is highly conserved in many Gram - negative pathogenic bacteria. The T3SS is known to be indispensable in establishing disease processes but no...
• Developmental trajectories of GABAergic cortical interneurons are sequentially modulated by dynamic FoxG1 expression levels AI翻译
  作者：Miyoshi, Goichi; Ueta, Yoshifumi; Yagasaki, Yuki; Kishi, Yusuke; Fishell, Gord; Machold, Robert P.; Miyata, Mariko
  作者单位：Gunma University; Tokyo Women's Medical University; New York University; University of Tokyo; University of Tokyo; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：GABAergic inhibitory interneurons, originating from the embryonic ventral forebrain territories, traverse a convoluted migratory path to reach the neocortex. These interneuron precursors undergo sequential phases of tangential and radial migration before settling into specific laminae during differentiation. Here, we show that the developmental trajectory of FoxG1 expression is dynamically controlled in these interneuron precursors at critical junctures of migration. By utilizing mouse genetic...
• Pregnancy is linked to faster epigenetic aging in young women AI翻译
  作者：Ryan, Calen P.; Lee, Nanette R.; Carba, Delia B.; Macisaac, Julie L.; Lin, David T. S.; Atashzay, Parmida; Belsky, Daniel W.; Kobor, Michael S.; Kuzawa, Christopher W.
  作者单位：Columbia University; University of San Carlos; BC Children's Hospital; BC Children's Hospital Research Institute; University of British Columbia; Columbia University; Canadian Institute for Advanced Research (CIFAR); University of British Columbia; Northwestern University
  摘要：A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accelerating biological aging. Supporting this prediction are findings that high fertility among women predicts shorter lifespan and poorer health later in life. However, biological aging is thought to begin before age- related health declines, limiting the applicability of morbidity and mortality for studying the aging process earlier in life. Here, we ...
• Topological wetting states of microdroplets on closed-loop structured surfaces: Breakdown of the Gibbs equation at the microscale AI翻译
  作者：Lin, Dongdong; Wang, Shixian; Xu, Wenwu; Chen, Yuhao; Li, Pei; Fang, Ye-Guang; Zhao, Wenhui; Duan, Xiangmei; Yang, Xinju; Jiang, Zuimin; Fang, Wei-Hai; Zeng, Xiao Cheng; Francisco, Joseph S.; Gao, Yurui
  作者单位：Ningbo University; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Beijing Normal University; City University of Hong Kong; University of Pennsylvania
  摘要：Microdroplets are a class of soft matter that has been extensively employed for chemical, biochemical, and industrial applications. However, fabricating microdroplets with largely controllable contact-area shape and apparent contact angle, a key prerequisite for their applications, is still a challenge. Here, by engineering a type of surface with homocentric closed-loop microwalls/microchannels, we can achieve facile size, shape, and contact-angle tunability of microdroplets on the textured su...
• Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion AI翻译
  作者：Murcia, Francisco Jose Lopez -; Lin, Kun - Han; Berns, Manon M. M.; Ranjan, Mrinalini; Lipstein, Noa; Neher, Erwin; Brose, Nils; Reim, Kerstin; Taschenberger, Holger
  作者单位：University of Gottingen; University of Gottingen; University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); University of Copenhagen
  摘要：The presynaptic SNARE- complex regulator complexin (Cplx) enhances the fusogenicity of primed synaptic vesicles (SVs). Consequently, Cplx deletion impairs action potential- evoked transmitter release. Conversely, though, Cplx loss enhances spontaneous and delayed asynchronous release at certain synapse types. Using electrophysiology and kinetic modeling, we show that such seemingly contradictory transmitter release phenotypes seen upon Cplx deletion can be explained by an additional of Cplx in...
• Exotic self-assembly of hard spheres in a morphometric solvent AI翻译
  作者：Spirandelli, Ivan; Coles, Rhoslyn; Friesecke, Gero; Evans, Myfanwy E.
  作者单位：University of Potsdam; Technical University of Berlin; Technische Universitat Chemnitz; Technical University of Munich
  摘要：The self -assembly of spheres into geometric structures, under various theoretical conditions, offers valuable insights into complex self -assembly processes in soft systems. Previous studies have utilized pair potentials between spheres to assemble maximum contact clusters in simulations and experiments. The morphometric approach to solvation free energy that we utilize here goes beyond pair potentials; it is a geometrybased theory that incorporates a weighted combination of geometric measure...
• Construction of the single- diamond- structured titania scaffold- Recreation of the holy grail photonic structure AI翻译
  作者：Wang, Chao; Cui, Congcong; Deng, Quanzheng; Zhang, Chong; Asahina, Shunsuke; Cao, Yuanyuan; Mai, Yiyong; Che, Shunai; Han, Lu
  作者单位：Tongji University; Tohoku University; East China University of Science & Technology; Shanghai Jiao Tong University
  摘要：As one of the most stunning biological nanostructures, the single- diamond (SD) surface discovered in beetles and weevils exoskeletons possesses the widest complete photonic bandgap known to date and is renowned as the holy grail of photonic materials. However, the synthesis of SD is difficult due to its thermodynamical instability compared to the energetically favoured bicontinuous double diamond and other easily formed lattices; thus, the artificial fabrication of SD has long been a formidab...
• An evolutionarily conserved ubiquitin ligase drives infection and transmission of flaviviruses AI翻译
  作者：Wu, Linjuan; Zhang, Liming; Feng, Shengyong; Chen, Lu; Lin, Cai; Wang, Gang; Zhu, Yibin; Wang, Penghua; Cheng, Gong
  作者单位：Tsinghua University; Peking University; Shenzhen Bay Laboratory; Shenzhen Center for Disease Control & Prevention (SZCDC); University of Connecticut
  摘要：Mosquito - borne flaviviruses such as dengue (DENV) and Zika (ZIKV) cause hundreds of millions of infections annually. The single- stranded RNA genome of flaviviruses is translated into a polyprotein, which is cleaved equally into individual functional proteins. While structural proteins are packaged into progeny virions and released, most of the nonstructural proteins remain intracellular and could become cytotoxic if accumulated over time. However, the mechanism by which nonstructural protei...