2024

最新文章

• Multi- axis fields boost SABRE hyperpolarization AI翻译
  作者：Lindale, Jacob R.; Smith, Loren L.; Mammen, Mathew W.; Eriksson, Shannon L.; Everhart, Lucas M.; Warren, Warren S.
  作者单位：Duke University; Duke University; Duke University; Duke University; Duke University
  摘要：The inherently low signal - to - noise ratio of NMR and MRI is now being addressed by hyperpolarization methods. For example, iridium - based catalysts that reversibly bind both parahydrogen and ligands in solution can hyperpolarize protons (SABRE) or heteronuclei (X- SABRE) on a wide variety of ligands, using a complex interplay of spin dynamics and chemical exchange processes, with common signal enhancements between 10(3 )and 10(4). This does not approach obvious theoretical limits, and furt...
• Thermodynamic properties and enhancement of diamagnetism in nitrogen doped lutetium hydride synthesized at high pressure AI翻译
  作者：Han, Yifeng; Ou, Yunbo; Sun, Hualei; Kopaczek, Jan; Leonel, Gerson J.; Guo, Xin; Brugman, Benjamin L.; Leinenweber, Kurt; Xu, Hongwu; Wang, Meng; Tongay, Sefaattin; Navrotsky, Alexandra
  作者单位：Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Sun Yat Sen University; Wroclaw University of Science & Technology; Arizona State University; Arizona State University-Tempe; Sun Yat Sen University
  摘要：Nitrogen doped lutetium hydride has drawn global attention in the pursuit of room- temperature superconductivity near ambient pressure and temperature. However, variable synthesis techniques and uncertainty surrounding nitrogen concentration have contributed to extensive debate within the scientific community about this material and its properties. We used a solid - state approach to synthesize nitrogen doped lutetium hydride at high pressure and temperature (HPT) and analyzed the residual sta...
• The dorsomedial prefrontal cortex prioritizes social learning during rest AI翻译
  作者：Jimenez, Courtney A.; Meyer, Meghan L.; Falk, Emily B.; Gazzaniga, Michael S.
  作者单位：Columbia University
  摘要：Sociality is a defining feature of the human experience: We rely on others to ensure survival and cooperate in complex social networks to thrive. Are there brain mechanisms that help ensure we quickly learn about our social world to optimally navigate it? We tested whether portions of the brain's default network engage by default to quickly prioritize social learning during the memory consolidation process. To test this possibility, participants underwent functional MRI (fMRI) while viewing sc...
• A type I interferon regulatory network for human plasmacytoid dendritic cells based on heparin, membrane- bound and soluble BDCA-2 AI翻译
  作者：Solis, Francisco Venegas-; Staliunaite, Laura; Rudolph, Elisa; Muench, Carina Chan - Song; Yu, Philipp; Freibert, Sven - A.; Maeda, Takahiro; Zimmer, Christine L.; Moebs, Christian; Keller, Christian; Kaufmann, Andreas; Bauer, Stefan
  作者单位：Philipps University Marburg; Philipps University Marburg; Philipps University Marburg; Philipps University Marburg; Nagasaki University; Philipps University Marburg
  摘要：Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFNs) after sensing viral/bacterial RNA or DNA by toll - like receptor (TLR) 7 or TLR9, respectively. However, aberrant pDCs activation can cause adverse effects on the host and contributes to the pathogenesis of type I IFN- related autoimmune diseases. Here, we show that heparin interacts with the human pDCs- specific blood dendritic cell antigen 2 (BDCA-2) but not with related lectins such as DCIR or dectin-2. Importantly, BDCA-...
• Negative trend in total solar irradiance over the satellite era AI翻译
  作者：Amdur, Ted; Huybers, Peter
  作者单位：Harvard University
  摘要：Linear trends in total solar irradiance (TSI) between different reconstructions of the satellite era, defined as 1978 to 2023, disagree by up to 0.17 W/m2 per decade. Furthermore, high-quality satellite radiometer observations of the most recent solar cycle, 24, systematically differ from estimates that rely on TSI proxies for reasons that have been unclear. Using a Bayesian Kalman filtering approach to estimate TSI from both satellite-based observations and proxies gives two complementary exp...
• Telling time in tumor samples reveals diversity of clock disruption AI翻译
  作者：Lamia, Katja A.
  作者单位：Scripps Research Institute
• Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage AI翻译
  作者：Jain, Akansha; Kim, Bo Ram; Yu, Wenjie; Moninger, Thomas O.; Karp, Philip H.; Wagner, Brett A.; Welsh, Michael J.
  作者单位：University of Iowa; University of Iowa; Howard Hughes Medical Institute; University of Iowa; University of Iowa
  摘要：Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely grouping mitochondria just beneath the apical membrane. However, this efficient localization comes at a cost because electrons leaked during oxidative phosphorylation react with molecular oxygen to form superoxide, and thus, the cluster of mitochondria creates a hotspot for oxidant production. The relatively hi...
• A rare germline BMP15 missense mutation causes hereditary ovarian immature teratoma in human AI翻译
  作者：Liu, Yakun; Fan, Hongwei; Kang, Xi; Hao, Yuntao; Wang, Na; Zheng, Hui; Li, Yan; Kang, Shan
  作者单位：Hebei Medical University; Hebei Medical University; Hebei Medical University
  摘要：Ovarian immature teratomas (OITs) are malignant tumors originating from the ovarian germ cells that mainly occur during the first 30 y of a female's life. Early age of onset strongly suggests the presence of susceptibility gene mutations for the disease yet to be discovered. Whole exon sequencing was used to screen pathogenic mutations from pedigrees with OITs. A rare missense germline mutation (C262T) in the first exon of the BMP15 gene was identified. In silico calculation suggested that the...
• The ALOG domain defines a family of plant- specific transcription factors acting during Arabidopsis flower development AI翻译
  作者：Rieu, Philippe; Beretta, Veronica Maria; Caselli, Francesca; Thevenon, Emmanuel; Lucas, Jeremy; Rizk, Mahmoud; Franchini, Emanuela; Caporali, Elisabetta; Paleni, Chiara; Nanao, Max H.; Kater, Martin M.; Dumas, Renaud; Zubieta, Chloe; Parcy, Francois; Gregis, Veronica
  作者单位：University of Geneva; INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); University of Milan; European Synchrotron Radiation Facility (ESRF)
  摘要：The ALOG (Arabidopsis LIGHT- DEPENDENT SHORT HYPOCOTYLS 1 (LSH1) and Oryza G1) proteins are conserved plant- specific Transcription Factors (TFs). They play critical roles in the development of various plant organs (meristems, inflorescences, floral organs, and nodules) from bryophytes to higher flowering plants. Despite the fact that the first members of this family were originally discovered in Arabidopsis, their role in this model plant has remained poorly characterized. Moreover, how these...
• Deportation threat predicts Latino US citizens and noncitizens' psychological distress, 2011 to 2018 AI翻译
  作者：Johnson, Amy L.; Levesque, Christopher; Lewis, Neil A., Jr.; Asad, Asad L.
  作者单位：Lehigh University; University System of Ohio; Kenyon College; Cornell University; Stanford University
  摘要：The national context of deportation threat, defined as the federal government's approach to deportation and/or deportation's salience to the US public, fluctuated between 2011 and 2018. US Latinos across citizenship statuses may have experienced growing psychological distress associated with these changes, given their disproportionate personal or proximal vulnerabilities to deportation. Drawing on 8 y of public- and restricted-access data from the National Health Interview Survey (2011 to 2018...