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作者：Kiyabu, Steven; Nelson, Daniel; Thomson, John; Schultz, Benjamin; Vincent, Timothy; Hertlein, Nathan; Gillman, Andrew; Criner, Amanda; Buskohl, Philip R.
作者单位：UES, Inc.; United States Department of Defense; United States Air Force
摘要：Nonlinear dynamics are pervasive phenomena in natural and synthetic material systems, where time-varying signals from different physical stimuli in the environment influence the material system behavior. Physical reservoir computing leverages these nonlinear dynamics to produce complex input-output mappings by interpreting the dynamical system as a physical recurrent neural network. A source of physical nonlinearity is crucial for enabling the reservoir to predict nonlinear relationships. Desp...
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作者：Koren, Ore; Weidmann, Nils B.
作者单位：Indiana University System; Indiana University Bloomington; University of Konstanz
摘要：The COVID- 19 pandemic has renewed attention to the far- reaching social implications of emerging infectious diseases, an issue with historical parallels in the transformative reshape political trust and fuel instability has remained underexplored. This study leverages a novel dataset on zoonotic disease outbreaks-including Ebola, Marburg, H1N1, and the Black Plague-and geolocated Afrobarometer survey data from dozens of African states to investigate whether exposure to these deadly outbreaks ...
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作者：Manna, Raj Kumar; Retzlaff, Emma M.; Hinman, Anna Maria; Lan, Yiling; Abdel-Razek, Osama; Bates, Mike; Hehnly, Heidi; Amack, Jeffrey D.; Manning, M. Lisa
作者单位：Syracuse University; Syracuse University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kharagpur; State University of New York (SUNY) System; SUNY Upstate Medical University; Syracuse University
摘要：Cells, tissues, and organs must change shape in precise ways during embryonic development to execute their functions. Multiple mechanisms including biochemical signaling pathways and biophysical forces help drive these morphology changes, but it has been difficult to tease apart their contributions, especially from tissue-scale dynamic forces that are typically ignored. We use a combination of mathematical models and in vivo experiments to study a simple organ in the zebrafish embryo called Ku...
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作者：Anand, Uttam; Patra, Shubhadeep; Sekar, Rohith Vedhthaanth; Garen, Craig R.; Woodside, Michael T.
作者单位：University of Alberta; University of Alberta; University of Alberta
摘要：Misfolding of the protein PrP causes prion diseases in mammals. Disease susceptibility varies widely among species, despite PrP sequences differing by only a few amino acids. How these differences alter PrP folding and misfolding remains unclear. We compared the folding dynamics of single PrP molecules from three species with different disease susceptibility: dogs (immune), hamsters (susceptible), and bank voles (extremely susceptible). Measurements with optical tweezers revealed important dif...
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作者：Leahy, Lily; Chown, Steven L.; Riskas, Hannah L.; Wright, Ian J.; Carlesso, Amelia G.; Hammer, Ian J.; Sanders, Nathan J.; Bishop, Tom R.; Parr, Catherine L.; Gibb, Heloise
作者单位：La Trobe University; Monash University; Western Sydney University; Macquarie University; Deakin University; University of Melbourne; University of Michigan System; University of Michigan; Cardiff University; University of Pretoria; University of Liverpool; University of New South Wales Sydney
摘要：Metabolic rate dictates life's tempo, yet how ecological and environmental factors integrate to shape metabolic traits remains contentious. Considering metabolic traits of 114 species of ants from seven subfamily clades along a 1,500 km climatic and soil phosphorus availability gradient in Australia, we tested four hypotheses relating to variation in metabolic rate due to niche conservatism, temperature, aridity, and ecological stoichiometry. We also tested the contested hygric hypothesis, whi...
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作者：Lena, Anna Maria; Smirnov, Artem; Mancini, Mara; Montanaro, Manuela; Ciccosanti, Fabiola; Foti, Valeria; Nardacci, Roberta; Fimia, Gian Maria; Mavilio, Mara; Federici, Massimo; Mauriello, Alessandro; Piacentini, Mauro; Melino, Gerry; Candi, Eleonora
作者单位：University of Rome Tor Vergata; University of Rome Tor Vergata
摘要：The transcription factor p63 is an essential regulator of epithelial development. Yet, the complexity at the 3 ' UTR, which gives rise to the three distinct C-terminal protein isoforms (alpha, f3, and gamma), remains unresolved and opens an investigation on the in vivo role of the C-terminus. This region, codified by exon 13, harbors genetic mutations leading to AEC syndrome. Here, we generated a mouse with a deletion of p63 exon 13 in keratin-14-expressing tissues and employed transcriptome, ...
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作者：Nelson, Melissa K.; Reed, Graeme
作者单位：Arizona State University; Arizona State University-Tempe; York University - Canada
摘要：Indigenous peoples have long histories and diverse contemporary practices of caring for and enhancing biodiversity at different scales, in rural and urban contexts. As has been researched and documented by the Convention on Biological Diversity and others, Indigenous peoples globally only constitute 5% of the world's population and control and care for just 20% of the Earth's surface yet protect nearly 80% of the world's remaining biodiversity. Indigenous peoples have forms of biodiversity con...
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作者：Chen, Kevin; Li, Xueke; Weaver, Mackenzie M.; Christiansen, Shannon A.; Horton, Annabelle L.; Mann, Michael E.
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：Nor'easters are coastal extratropical cyclones that feed upon both thermal contrasts (meridional and land-ocean) and oceanic latent heat release, causing them to intensify along the U.S. East Coast. With central pressures that sometimes rival those of tropical cyclones, they represent a significant coastal hazard and are often associated with strong winds, heavy snowfall, disruption, and damage. While interest in studying the impacts of climate change on storm behavior is growing, nor'easters ...
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作者：Posor, York; Conduit, Sarah E.; Pearce, Wayne; Morelli, Daniele; Constantinou, Georgia; Whitehead, Maria; Sebire, Neil J.; Scudamore, Cheryl L.; Peltzer, Nieves; Walczak, Henning; Vanhaesebroeck, Bart
作者单位：University of London; University College London; Leibniz Association; Leibniz Forschungsinstitut furr Molekulare Pharmakologie (FMP); University of London; University College London; University of Cologne; University of Cologne; University of Stuttgart; University of Cologne
摘要：The organismal roles of the class II PI3K isoform PI3K-C2 alpha remain poorly understood. Recent studies have found PI3K-C2 alpha to promote arterial thrombosis and breast cancer metastasis, generating interest in this kinase as a drug target, with small molecule PI3K-C2 alpha inhibitors now available. However, the consequences of systemic PI3K-C2 alpha inactivation in the nondiseased, postnatal state are largely unknown. Here, we show that induction of genetic PI3K-C2 alpha inactivation in ad...
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作者：Zhang, Lei; Sha, Ruojie; Chaikin, Paul
作者单位：New York University; New York University
摘要：Self- replication and exponential growth are essential to all living things, the driving force for Darwinian evolution, and potentially useful in nanotechnology for large- scale production of nanoscopic materials. An artificial (nonliving) self- replication system has been shown to exhibit exponential growth and selection using DNA monomer origami tiles templated on a dimer seed. That system purposefully avoided the use of enzymes to get a hint of how self- replication might have evolved in a ...
