29期

最新文章

• Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes AI翻译
  作者：Sanchez-Hernandez, Raul; Benitez-Angeles, Miguel; Talyzina, Irina A.; Llorente, Itzel; Gonzalez-Avendano, Mariela; Sierra, Felix; Mendez-Resendiz, Angelica; Mercado, Francisco; Vergara-Jaque, Ariela; Sobolevsky, Alexander I.; Islas, Leon D.; Rosenbaum, Tamara
  作者单位：Universidad Nacional Autonoma de Mexico; Columbia University; Universidad de Talca; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz
  摘要：The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in primary nociceptive afferents, which participate in processes such as pain and inflammation. Considerable efforts have been directed toward finding inhibitors of TRPV1 and understanding the molecular details of their interactions with this channel. alpha- humulene (AH) is a sesquiterpene derived from plants such as hops and other members of Cannabaceae family, with a long history of popular use as an analgesic and...
• Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo AI翻译
  作者：V. Shuvaev, Vladimir; Tam, Ying K.; Lee, Benjamin W.; Myerson, Jacob W.; Herbst, Alan; Kiseleva, Raisa Yu.; Glassman, Patrick M.; Parhiz, Hamideh; Alameh, Mohamad-Gabriel; Pardi, Norbert; Muramatsu, Hiromi; Shuvaeva, Tea I.; Arguiri, Evguenia; Marcos-Contreras, Oscar A.; Hood, Elizabeth D.; V. Brysgel, Taylor; Nong, Jia; Papp, Tyler E.; Eaton, Deborah M.; Riley, Rachel; Palanki, Rohan; Musunuru, Kiran; Brenner, Jacob S.; Mitchell, Michael J.; Ferrari, Victor A.; Mui, Barbara L.; Semple, Sean C.; Weppler, Sherry A.; Atluri, Pavan; Margulies, Kenneth B.; Weissman, Drew; Muzykantov, Vladimir R.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Rowan University
  摘要：Lipid nanoparticles (LNP) represent a versatile platform for improving delivery of therapeutic nucleic acids. Yet, delivery to the myocardium remains a formidable challenge due to local barriers in the heart and systemic hindrances. In particular, plasma apolipoprotein E (apoE) directs LNP to the liver, limiting potential extrahepatic delivery. Here, we report a cardiotropic LNP (cLNP), which within 30 min post-intravenous injection accumulates in the heart of ApoE knockout (Apoe-/-) mice. The...
• Empowering cities globally: Four levers for transformative urban adaptation with nature- based solutions AI翻译
  作者：Diep, Loan; McPhearson, Timon
  作者单位：The New School; Cary Institute of Ecosystem Studies; Stockholm University; Royal Swedish Academy of Sciences; Beijer Institute of Ecological Economics
  摘要：The latest report of the Intergovernmental Panel on Climate Change showed that upcoming decades are likely to be accompanied with an increase in climate impacts in urban areas, thereby stressing the need for empowering cities to help them address the challenges ahead by closing the urban adaptation gap. The lock-in systems in which cities are often trapped create resistance to change and leads to missed opportunities to cocreate better futures. Putting nature at the center of urban adaptation ...
• Resource-use plasticity governs the causal relationship between traits and community structure in model microbial communities AI翻译
  作者：McGuinness, Brendon; Weber, Stephanie C.; Guichard, Frederic
  作者单位：McGill University; McGill University; McGill University
  摘要：Resolving the relationship between species' traits and their relative abundance is a central challenge in ecology. Current hypotheses assume relative abundances either result from or are independent of traits. However, despite some success, these hypotheses do not integrate the feedback interactions between traits and abundances to predictions of community structure such as relative abundance distributions and trait-abundance relationships. Here, we study how plasticity in resource-use traits ...
• Norms emerge through iterated learning AI翻译
  作者：Partington, Scott; Kamtekar, Rachana; Nichols, Shaun
  作者单位：University of Cambridge; Cornell University
  摘要：Injunctive norms are universal: Every culture has rules that specify what actions are forbidden, obligatory, or permitted. Where do all of these norms come from? In this paper, we identify a mechanism of cultural transmission that can explain the emergence of injunctive norms. In particular, we develop an iterated learning account that shows how weak biases in pedagogy and inference can drive norm emergence through cultural transmission. Using transmission chain studies, we confirm the core pr...
• Unusual bone bed reveals a vertebrate community with pterosaurs and turtles in equatorial Pangaea before the end- Triassic extinction AI翻译
  作者：Kligman, Ben T.; Whatley, Robin L.; Ramezani, Jahandar; Marsh, Adam D.; Lyson, Tyler R.; Fitch, Adam J.; Parker, William G.; Behrensmeyer, Anna K.
  作者单位：Smithsonian Institution; Smithsonian National Museum of Natural History; Massachusetts Institute of Technology (MIT)
  摘要：Temporally constrained microvertebrate bone beds are powerful tools for understanding continent-scale biotic change. Such sites are rare globally in nonmarine settings during the 12 million years (Ma) preceding the end-Triassic extinction (ETE; similar to 201.5 Ma), obscuring patterns of faunal change across this interval. A vertebrate assemblage from Arizona, USA, provides unique insights into community composition and ecology prior to the ETE. PFV 393 is a macro- and microvertebrate bone bed...
• Decoding nature's grammar with DNA language models AI翻译
  作者：Morrell, Peter L.; Pakhomov, Serguei, V
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
• Bistable random momentum transfer in a linear on- chip resonator AI翻译
  作者：Gu, Tingyi; Chang, Lorry; Wu, Jiagui; Wu, Lijun; Lee, Hwaseob; Chen, Young-Kai; Rahim, Masudur; Dong, Po; Wong, Chee Wei
  作者单位：University of Delaware; Columbia University; University of California System; University of California Los Angeles; United States Department of Energy (DOE); Brookhaven National Laboratory
  摘要：Optical switches and bifurcation rely on the nonlinear response of materials. Here, we demonstrate linear temporal bifurcation responses in a passive multimode microresonator, with strongly coupled chaotic and whispering gallery modes (WGMs). In micro-disks, the chaotic modes exhibit broadband transfer within the deformed cavities, but their transient response is less explored and yields a random output of the analog signal distributed uniformly from 0 to 1. Here, we build chaotic states by pe...
• Spirandelli et al., Exotic self-assembly of hard spheres in a morphometric solvent (vol 121, e2314959121, 2024) AI翻译
  作者：Spirandelli, Ivan; Coles, Rhoslyn; Friesecke, Gero; Evans, Myfanwy E.
• Cell- type- informed genotyping of mosaic focal epilepsies reveals cell- autonomous and non- cell- autonomous disease- associated transcriptional programs AI翻译
  作者：Bizzotto, Sara; Talukdar, Maya; Stronge, Edward A.; Ramirez, Rosita B.; Yang, Yingxi; Huang, August Yue; Hu, Qiwen; Hou, Yingping; Hylton, Norma K.; Finander, Benjamin; Tillett, Ashton; Zhou, Zinan; Chhouk, Brian H.; D'Gama, Alissa M.; Yang, Edward; Green, Timothy E.; Reutens, David C.; Mullen, Saul A.; Scheffer, Ingrid E.; Hildebrand, Michael S.; Buono, Russell J.; Blumcke, Ingmar; Poduri, Annapurna H.; Khoshkhoo, Sattar; Walsh, Christopher A.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; Austin Research Institute; University of Queensland; Royal Brisbane & Women's Hospital; Murdoch Children's Research Institute; Rowan University; Cooper Medical School of Rowan University; University of Erlangen Nuremberg; Cleveland Clinic Foundation; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute
  摘要：While it is widely accepted that somatic variants that activate the PI3K-mTOR pathway are a major cause of drug-resistant focal epilepsy, typically associated with focal cortical dysplasia (FCD) type 2, understanding the mechanism of epileptogenesis requires identifying genotype-associated changes at the single-cell level, which is technically challenging with existing methods. Here, we performed single-nucleus RNA-sequencing (snRNA-seq) of 18 FCD type 2 samples removed surgically for treatmen...