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作者：Zhang, Juan; Zhang, Hui-Lin; Xu, Xin-Rong; Feng, Yan-Li; Zhu, Qi-Meng; Morisseau, Christophe; Qiu, Feng; Hammock, Bruce D.; Sun, Cheng-Peng
作者单位：Tianjin University of Traditional Chinese Medicine; University of California System; University of California Davis
摘要：Neuroinflammation is a complex immunological phenomenon characterized by a dysregulated inflammatory response in the central nervous system (CNS) that can be triggered by various pathological injuries, such as toxins, which are involved in Parkinson's and Alzheimer's diseases (PD and AD), therefore, suppressing neuroinflammation serves as an effective treatment for CNS diseases. Herein, we found that natural soluble epoxide hydrolase (sEH) inhibitor 1-O-acetyl-4R,6S-britannilactone (AB) regula...
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作者：Mas- Herrero, Ernest; Marco- Pallares, Josep
作者单位：University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Hospital Duran i Reynals
摘要：Current models suggest that musical pleasure is tied to the intrinsic reward of learning, as it relies on predictive processes that challenge our minds. According to predictive coding, optimal learning, which maximizes epistemic value, depends on balancing predictability and uncertainty, implying that musical pleasure should also reflect this equilibrium. We tested this idea in two independent large samples using a novel decision- making paradigm, where participants indicated preferences for m...
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作者：Frantzeskaki, Niki; Wijsman, Katinka; Kabisch, Nadja; McPhearson, Timon
作者单位：Utrecht University; Leibniz University Hannover; The New School; Cary Institute of Ecosystem Studies; Stockholm University; Royal Swedish Academy of Sciences; Beijer Institute of Ecological Economics
摘要：Nature- based solutions (NBS) are used to transform existing unsustainable and undesirable path dependencies in cities. For NBS to contribute to just urban transformations, a stronger inter- and transdisciplinary knowledge base is needed. This knowledge base is essential to engage with six complex yet crucial questions about NBS, including for what?, which nature?, where?, how?, when, and for whom?. To address these questions, we identify two critical opportunities to advance the knowledge of ...
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作者：Gao, Kaixuan; Zhang, Xin; Nie, Jia; Meng, Hengyu; Zhang, Weishe; Tian, Boxue; Liu, Xiangyu
作者单位：Tsinghua University; Tsinghua University; Central South University
摘要：G protein-coupled receptors (GPCRs) play pivotal roles in cellular signaling and represent prominent drug targets. Structural elucidation of GPCRs is crucial for drug discovery efforts. However, structural studies of GPCRs remain challenging, particularly for inactive-state structures, which often require extensive protein engineering. Here, we present a de novo design strategy termed click fusion for generating fusion proteins to facilitate GPCR structural studies. Our method involves the rat...
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作者：Skeels, Alexander; Sauquet, Herve; Mast, Austin; Weston, Peter H.; Olde, Peter M.; Jordan, Gregory J.; Carpenter, Raymond J.; Fenker, Jessica; Reynolds, Zoe K. M.; Lemmon, Alan R.; Lemmon, Emily Moriarty; Pichardo-Marcano, Fritz J.; Cardillo, Marcel
作者单位：Australian National University; University of New South Wales Sydney; State University System of Florida; Florida State University; University of Tasmania; University of Adelaide; State University System of Florida; Florida State University
摘要：Theories of adaptive radiation propose predictable trajectories in which diversity accumulates rapidly in newly formed or colonized environments with underexploited niche space and few competing species, before slowing down as competition intensifies, and speciation and extinction rates approach equilibrium. This historical perspective on diversity may be more important than current environmental variation for explaining today's biodiversity, but this has been difficult to determine because of...
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作者：Beal, Ty; Manohar, Swetha; Miachon, Lais; Fanzo, Jessica
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作者：Carozza, Sofia; Kletenik, Isaiah; Astle, Duncan; Schwamm, Lee; Dhand, Amar
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作者：Komarova, Ksenia; Gelfand, Natalia A.; Remacle, Francoise; Levine, Raphael D.; Chakraborty, Subrata; Jackson, Teresa L.; Kostko, Oleg; Thiemens, Mark H.
作者单位：Hebrew University of Jerusalem; University of Liege; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California San Diego; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Southern California
摘要：Stable isotope ratio measurements provide valuable insights into a broad range of natural processes, from planetary atmospheres and climate to interstellar chemistry. Nitrogen, which has two stable isotopes, exhibits varying isotope ratios across the solar system. To model these observations, the isotope fraction as a function of energy is essential. At the Advanced Light Source (ALS), we measured the photodissociation of molecular nitrogen (N2) with vacuum UV photons where a single photon is ...
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作者：Hanson, Lucas C.; Reinhardt, William H.; Shrager, Scott; Sivakumar, Tarunyaa; Miskin, Marc Z.
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：Semiconductor microelectronics are emerging as a powerful tool for building smart, autonomous sub-millimeter robots. Yet a number of existing microrobot platforms, despite significant advantages in speed, robustness, power consumption, or ease of fabrication, have no clear path toward electronics integration, limiting their potential for intelligence. Here, we show how to upgrade a class of self-propelled particles into electronically integrated microrobots, reaping the best of both platforms ...
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作者：Wainwright, J. Benito; Loupasaki, Theodora; Ramirez, Francisco; Penry, Iestyn L.; England, Sam J.; Barker, Annalie; Meier, Joana I.; How, Martin J.; Roberts, Nicholas W.; Troscianko, Jolyon; Montgomery, Stephen H.
作者单位：University of Bristol; Pontificia Universidad Catolica del Ecuador; Leibniz Institut fur Evolutions und Biodiversitatsforschung; University of Cambridge; Wellcome Trust Sanger Institute; University of Exeter; University of St Andrews
摘要：Niche partitioning within variable habitats can expose species to distinct sensory information. Vision is the primary sensory modality used by many animals to interact with their habitat. However, the role of terrestrial light environment properties in shaping species assemblages and visual system evolution is not fully understood. By studying a diverse, sympatric community of mimetic butterflies, we demonstrate that forest architecture creates a mosaic of light microhabitats that drive adapti...
