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作者：Zhou, Lei; Song, Qingying; Zhang, Xin; Cao, Mengnian; Xue, Dayu; Sun, Yiwen; Mao, Meihua; Li, Xinling; Zhang, Zhenzhong; Liu, Junjie; Shi, Jinjin
作者单位：Zhengzhou University; Zhengzhou University
摘要：Glioblastoma multiforme (GBM) is one of the most aggressive intracranial tumors for which there is no effective treatment. Chimeric antigen receptor macrophage (CAR-M) therapies have demonstrated impressive therapeutic efficacy in solid tumors; however, the cost and rigor associated with manufacturing engineered macrophages ex vivo can be prohibitive. Here, we utilized enucleated mesenchymal stem cells (MSCs) as vehicles for the targeted delivery of CAR-encoding plasmid to reprogram glioma-ass...
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作者：Fang, Linfa; Lakshmanan, Prakash; Zhang, Hailin; Deng, Yue; Xiao, Ran; Wen, Teng; Ma, Bin; Ge, Tida; Mueller, Christoph; Zhang, Jinbo; Chen, Xinping; Zhu, Yongguan; Su, Xiaoxuan
作者单位：Southwest University - China; Southwest University - China; Guangxi Academy of Agricultural Sciences; University of Queensland; Nanjing Normal University; Zhejiang University; Ningbo University; Justus Liebig University Giessen; Justus Liebig University Giessen; University College Dublin; University College Dublin; Chinese Academy of Sciences
摘要：Viruses are ubiquitous regulators of microbial dynamics and may thus greatly influence global microbial- driven greenhouse gas emissions. Anthropogenic stressors, such as chemical contamination, are likely to amplify these viral contributions; however, their global significance and underlying mechanisms remain elusive. Utilizing 15N tracing, metagenomics, and laboratory assays, we explore soil viral communities and their evolutionary potential under the stress from antibiotic ciprofloxacin (CI...
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作者：Ghosh, Shirsendu; Wiesner, Alice Wagenknecht -; Desai, Shriya; Vyphuis, Jada; Ramos, Mariena Silvestry; Grazul, John L.; Baird, Barbara A.
作者单位：Cornell University; Cornell University
摘要：Similar to T cells and B cells, mast cell surfaces are dominated by microvilli, and like these other immune cells we showed with microvillar cartography (MVC) that key signaling proteins for RBL mast cells localize to these topographical features. Although stabilization of ordered lipid nanodomains around antigen-crosslinked IgE-Fc epsilon RI is known to facilitate necessary coupling with Lyn tyrosine kinase to initiate transmembrane signaling in these mast cells, the relationship of ordered-l...
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作者：Hardcastle, Matthew
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作者：Li, Yingjie; Zhou, Shiyao; Fu, Wangxian; Li, Xinchao; Chen, Tao; Le, Hao; Xu, Yangsong; Tang, Yuting; Mi, Peng; Gao, Huile; Wu, Qinjie; Gong, Changyang
作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University
摘要：Immune checkpoint blockade (ICB) has potential in alleviating cytotoxic T lymphocyte (CTL) exhaustion. However, resistance that impaired major histocompatibility complex class I (MHC-I) expression on tumors can be developed in many patients after ICB treatment, resulting in insufficient antigen presentation to CTLs. Herein, we rationally design a versatile and powerful immunomodulated hierarchical nanoCRISPR converter (SWITCH) targeting PD-L1 and PCSK9 loci to convert the immune-resistance sta...
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作者：Gowen, Savannah D.; Ghimire, Elina; Lindberg, Charlie A.; Appen, Ingrid S.; Rowan, Stuart J.; Nagel, Sidney R.
作者单位：University of Chicago; University of Chicago; University of Chicago; University of Chicago
摘要：Training has emerged as a promising materials design technique in which function can be achieved through repeated physical modification of an existing material rather than by direct chemical functionalization, cutting, or reprocessing. This work investigates both the ability to train for function and then to erase that function on-demand in macroscopic metamaterials made from liquid crystal elastomers. We first show that the Poisson's ratio of these disordered arrays can be tuned via directed ...
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作者：Hirata, Keisuke; Fujimiya, Kana; Ostermann, Andreas; Schrader, Tobias E.; Hiromoto, Takeshi; Goto, Masataka; Arimori, Takao; Hirano, Yu; Kusaka, Katsuhiro; Tamada, Taro; Nakamura, Teruya
作者单位：Kumamoto University; Kumamoto University; Technical University of Munich; Helmholtz Association; Research Center Julich; National Institutes for Quantum Science & Technology; University of Osaka; Chiba University; Comprehensive Research Organisation for Science & Society
摘要：Human MTH1, a Nudix enzyme, hydrolyzes several oxidized nucleotides such as 8-oxo-dGTP and 2-oxo-dATP, owing to its broad substrate specificity. MTH1 has also attracted attention as an anticancer target, and its substrate recognition is of biological and medical interest. Previous studies have suggested that MTH1 exhibits broad substrate specificity by changing the protonation states of Asp119 and Asp120 with high pKa. However, the recognition mechanism remains unclear, owing to the difficulty...
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作者：Hunt, Joshua B.; Buteau, Anna; Barreto, Joe; Hanson, Spencer; Scholl, Benjamin; Poleg-Polsky, Alon; Felsen, Gidon
作者单位：University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus
摘要：How do sensory systems account for stimuli generated by natural behavior? We addressed this question by examining how an ethologically relevant class of saccades modulates visual representations in the mouse superior colliculus (SC), a key region for sensorimotor integration. Leveraging the conserved natural tendency to make saccades that reset the eye-head angle to a default position via the optokinetic reflex, we developed an efficient and unbiased white noise approach to study the modulatio...
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作者：Sungeelee, Selvee; Mailhes, Caroline; Chettouh, Zoubida; Bokiniec, Phillip; Eymael, Annaliese; McMullan, Simon; Lena, Clement; Dempsey, Bowen; Brunet, Jean-Francois
作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); University of Queensland; Macquarie University
摘要：The first phase of feeding consists in the procurement of solid foods from the environment by biting, and their preparation for swallowing by chewing. These actions require the precise coordination of tens of orofacial muscles for the jaw and tongue. The seat for this motor patterning is known to reside in the reticular formation, a complex and poorly mapped region of the hindbrain, but the neuron groups involved are still elusive. Here, we characterize a group of excitatory reticular interneu...
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作者：Stasenko, Alena; Kaestner, Erik; Schadler, Adam J.; Reyes, Anny; Urbanic, Clare; Helm, Jonathan L.; Saldana, Daniel; Carollo-Duprey, Giselle; Polczynska, Monika; Benjamin, Christopher; Sepeta, Leigh N.; Gollan, Tamar H.; Cavanagh, Lucia; McDonald, Carrie R.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Cleveland Clinic Foundation; California State University System; San Diego State University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; California Lutheran University; University of California System; University of California Los Angeles; University of British Columbia; Children's National Health System; University of California System; University of California San Diego
摘要：Are bilingual language networks flexible enough to dynamically adapt to neurological insult? We examined language lateralization in 24 bilingual and 46 monolingual adults with temporal lobe epilepsy using functional MRI. In a group of primarily early sequential bilingual patients, the first acquired language (L1) showed more bilateral lateralization than in monolingual patients, with no effect of seizure onset laterality. In contrast, the second- acquired language (L2) was more bilateral in th...
