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作者:McPhearson, Timon; Frantzeskaki, Niki; Ossola, Alessandro; Diep, Loan; Anderson, Pippin M. L.; Blatch, Timothy; Collier, Marcus J.; Cook, Elizabeth M.; Fatti, Christina Culwick; Grabowski, Zbigniew J.; Grimm, Nancy B.; Haase, Dagmar; Herreros-Cantis, Pablo; Kavonic, Jessica; Lin, Brenda B.; Meneses, Duvan H. Lopez; Matsler, A. Marissa; Moglia, Magnus; Morato, Jordi; O'Farrell, Patrick; Roy, Parama; Singh, Chandni; Wang, Jing; Zhou, Weiqi
作者单位:The New School; Cary Institute of Ecosystem Studies; Stockholm University; Royal Swedish Academy of Sciences; Beijer Institute of Ecological Economics; Utrecht University; University of California System; University of California Davis; University of Melbourne; Macquarie University; University of Cape Town; Trinity College Dublin; Columbia University; University of Connecticut; University of Connecticut; Arizona State University; Arizona State University-Tempe; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Basque Centre for Climate Change (BC3); Autonomous University of Barcelona; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Universitat Politecnica de Catalunya; University System of Maryland; University of Maryland College Park; Swinburne University of Technology; Universitat Politecnica de Catalunya; University of the Western Cape; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Indian Institute for Human Settlements (IIHS); Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要:Nature-based solutions(NbS) have emerged as a key strategy for sustainably addressing multiple urban challenges, with rapidly increasing knowledge production requiring synthesis to better understand whether and how NbS work in different social, ecological, economic, or governance contexts. Insights in this Perspective are drawn from a thematic review of 61 NbS review articles supported by an expert assessment of NbS knowledge in seven global regions to examine key challenges, fill gaps in Glob...
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作者:Rontgen, Alexander; Toprakcioglu, Zenon; Morris, Owen M.; Vendruscolo, Michele
作者单位:University of Cambridge
摘要:The aggregation of amyloid-beta (A beta) and alpha- synuclein (alpha Syn) into insoluble proteinaceous deposits is a hallmark of Alzheimer's and Parkinson's diseases. Recent evidence suggests that these amyloidogenic proteins act in synergy, with their coaggregation frequently observed in these disorders. In this study, we investigate the interaction of A beta and alpha Syn using various biophysical tools. In particular, we explore the cocondensation of A beta with alpha Syn, elucidating the p...
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作者:Thygesen, Uffe Hogsbro
作者单位:Technical University of Denmark
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作者:Limbu, Smriti Pehim; Sturmer, Sidney L.; Zahn, Geoffrey; Aguilar-Trigueros, Carlos A.; Rogers, Noah; Chaudhary, V. Bala
作者单位:Dartmouth College; Universidade Regional de Blumenau (FURB); University of Jyvaskyla; Utah System of Higher Education; Utah Valley University
摘要:Climate-driven variation in traits is crucial for predicting ecological responses to environmental change, yet global patterns and drivers of microbial trait variation remain poorly understood. Using global datasets of arbuscular mycorrhizal (AM) fungal observations linked to spore morphological traits, we show that climate shapes spore trait variation and functional diversity. Larger spore volumes were more prevalent in warm, wet climates but were associated with smaller species range sizes, ...
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作者:Passi, Anurag; Tec-Campos, Diego; Kumar, Manish; Tibocha-Bonilla, Juan D.; Zuniga, Cristal; Peacock, Beth; Hale, Amanda; Santibanez-Palominos, Rodrigo; Borneman, James; Zengler, Karsten
作者单位:University of California System; University of California San Diego; Universidad Autonoma de Yucatan; University of California System; University of California Riverside; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要:Understanding plant response to environmental factors such as temperature, drought, diseases, and carbon-to-nitrogen (C:N) ratio is essential for crop resilience, quality, and adaptation to climate change. Here, we present iCitrus2616, a high-resolution organ-specific genome-scale metabolic model for Citrus clementina, comprising 2,616 genes, 8,653 metabolites, and 10,654 reactions. The model integrates organ-specific metabolomics data, i.e., leaf, stem, and root, and predicts plant responses ...
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作者:Alonso, Rodrigo G.; Gianoli, Francesco; Fabella, Brian; Hudspeth, A. J.
作者单位:Rockefeller University; Howard Hughes Medical Institute; Rockefeller University
摘要:Hearing hinges upon the ear's ability to enhance its responsiveness by means of an energy-expending active process that amplifies the very mechanical inputs that it detects. This process is defined by four properties that, although seemingly unrelated, consistently occur together: amplification, sharp frequency tuning, compressive nonlinearity, and spontaneous otoacoustic emission. In nonmammal tetrapods, the active process is evident in individual hair cells. The hair bundles of the bullfrog,...
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作者:Dashti, Damon; Luepken, Luca M.; Seidisarouei, Mohammad; Forbes, Paul A. G.; Schnitzler, Alfons; Kalenscher, Tobias
作者单位:Heinrich Heine University Dusseldorf; University of Zurich; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital
摘要:Stress changes social behavior, yet its effects remain contradictory. Traditionally, stress was thought to trigger an antagonistic fight- or- flight response aimed at eliminating the stressor. However, recent studies have revealed the opposite response, tend- and- befriend, where individuals prosocially invest in their social network in exchange for support and mutual protection. We hypothesize that stress does not promote one response over the other; instead, it stimulates both behaviors, dis...
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作者:Liu, Yuchen; Sarker, A. H. M. Raihan; Sripa, Banchob; Tangkawattana, Sirikachorn; Khieu, Virak; Nevin, William; Paterson, Steve; Viney, Mark
作者单位:University of Liverpool; University of Chittagong; Khon Kaen University; Khon Kaen University; National Center Parasitology, Entomology & Malaria Control; Liverpool School of Tropical Medicine; Imperial College London; Royal Centre for Defence Medicine; University of Birmingham
摘要:Gut nematode worms are important parasites of people and other animals. The parasitic and is one of the soil- transmitted helminthiases, a WHO- defined neglected tropical disease. It has long been suggested that human S. stercoralis infection may be a zoonosis from dogs. We investigated this by whole genome sequence analysis of S. stercoralis from sympatric human and dog populations in Asia. We find that human- and dog- derived S. stercoralis have genetically distinct nuclear genomes, but we a...
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作者:Morales, Guillermo B.; Munoz, Miguel A.; Tu, Yuhai
作者单位:University of Granada; Simons Foundation; Flatiron Institute; Simons Foundation; Flatiron Institute
摘要:The brain encodes external stimuli through patterns of neural activity, forming internal representations of the world. Increasing experimental evidence showed that neural representations for a specific stimulus can change over time in a phenomenon called representational drift (RD). However, the underlying mechanisms for this widespread phenomenon remain poorly understood. Here, we study RD in the piriform cortex of the olfactory system with a realistic neural network model that incorporates t...
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作者:Nicolas, Jenny R.; Hui, Zeyu; Miao, Qiushi; Lin, Haichen; Davidson, Michael R.; Liu, Ping
作者单位:University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要:Characterizing the morphology of lithium (Li) is crucial for developing long-lasting lithium metal batteries. It is well established that more uniform Li deposition correlates with better cell performance. Li morphology is often characterized through qualitative analysis of scanning electron microscopy (SEM) images; however, there are no widely accepted metrics to quantitatively describe deposition uniformity. Here, we propose a framework to quantify uniformity through SEM image analysis via t...