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作者：Wang, Zhen; Anderson, David M. G.; Messinger, Jeffrey D.; Curcio, Christine A.; Schey, Kevin L.
作者单位：Vanderbilt University; Vanderbilt University; University of Alabama System; University of Alabama Birmingham
摘要：The retinal pigment epithelium (RPE) is the metabolic gatekeeper to the photoreceptors, thus playing many essential roles in healthy vision. Under certain conditions, RPE cells may transdifferentiate and migrate from the RPE layer. Ectopic RPE cells are potential signal sources for hyperreflective foci, prominent clinically visible biomarkers in age-related macular degeneration, which causes central vision loss globally. Applying multiple imaging modalities including ex vivo optical coherence ...
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作者：Guo, Jun-Chen; Chai, Cong-Zheng; Wang, Ya-Hui; Zhao, Yao; Xin, Sen; Zhang, Ying; Guo, Yu-Guo; Bai, Chunli
作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Chemistry, CAS
摘要：Lithium (Li) metal batteries offer high energy density but face significant safety challenges due togas evolution under thermal abuse conditions. At the anode, the reduction of organic carbonate-based electrolytes generates flammable gases (e.g., H2, CH4), while the poor thermal stability of the cathode results in the release of O2, CO, and CO2. The accumulation of these gases contributes to mechanical rupture, and their migration further exacerbates thermal runaway. To address these challenge...
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作者：Liu, Shuting; Chen, Junyao; Chen, Haiqiao; Guo, Yanan; Yuan, Fa; Xiao, Dongchang; Xiang, Mengqing
作者单位：Sun Yat Sen University; Sun Yat Sen University
摘要：The retinal photoreceptors possess specialized sensory cilia critical for phototransduction while the nonphotoreceptor cells typically exhibit simpler primary cilia or lack them altogether. This dichotomy in ciliary architecture underpins the functional specialization of retinal cell types, but how this dichotomy arises and is maintained remains elusive. This study explores the role of the transcription factor Foxn3 in establishing and maintaining this divergence. We generated retina-specific ...
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作者：Mitani, Takahiro; Takeda, Shuichi; Oda, Toshiro; Narita, Akihiro; Maeda, Yuichiro; Honda, Hajime; Fujiwara, Ikuko
作者单位：Nagaoka University of Technology; Nagoya University; Tokai Gakuin University; Nagoya University
摘要：Cytochalasin D (CytoD), a widely used actin inhibitor, is typically employed in cell studies as a simple barbed end capper. However, accumulating evidence suggests broader effects on actin dynamics. We addressed this by observing single actin filaments using total internal reflection fluorescence microscopy. Our depolymerization assay confirmed that, at nanomolar concentrations, CytoD tightly caps barbed ends. The K1/2 for inhibition was 4.1 nM, consistent with previous bulk measurements, and ...
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作者：Argenziano, Rossella; Gilboa, Itzhak
作者单位：University of Essex; Hautes Etudes Commerciales (HEC) Paris; Reichman University
摘要：We study the decision problem of a Proposer who has a set of applications to submit for approval to an Authority and can choose an order of submission. The Proposer's utility depends on the Authority's rulings. The Authority has to be consistent with its past decisions, which we model using the nearest-neighbor criterion. If the Proposer's utility increases with the set of approved applications, then any greedy strategy is optimal for her: She should submit any application that, given the curr...
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作者：Fan, Pan; Liu, Yaqing; Liu, Chunyue; Yao, Hao; Xu, Shibo; Jiang, Yueqing; Wu, Yang; Liu, Yan; Guo, Xing
作者单位：Nanjing Medical University; Nanjing Medical University; Nanjing Medical University; Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; Nanjing Medical University; Nanjing Medical University; Nanjing Medical University
摘要：Impairment of mitochondrial protein stability is associated with neurodegeneration in Huntington's disease (HD). However, the E3 ligase responsible for maintaining mitochondrial protein homeostasis in HD remains poorly understood. In this study, we demonstrate that NEDD4L protein levels are elevated in human striatal organoids (hSOs) derived from induced pluripotent stem cells of patients as well as in a mouse model of HD. Overexpression of NEDD4L leads to degeneration and cell death of medium...
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作者：Hoff, Hannah K.; Littleford-Colquhoun, Bethan L.; Kartzinel, Rebecca Y.; Anderson, Heidi M.; Geremia, Chris; McGarvey, Lauren M.; Segal, Carlisle; Kartzinel, Tyler R.
作者单位：Brown University; Brown University; Brown University; Montana State University System; Montana State University Bozeman
摘要：Evaluating species' roles in food webs is critical for advancing ecological theories on competition, coexistence, and biodiversity but is complicated by pronounced dietary variability within species and overlap across species. We combined dietary DNA metabarcoding, GPS tracking, and a machine-learning algorithm to cluster and compare dietary profiles within and among five migratory large-herbivore species from Yellowstone National Park. Interspecific niche partitioning was weak, but statistica...
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作者：Jankovic, Matija; Kang, Seungmin; Bhattacharya, Sarnab; Kashanchi, Jordon; Wang, Jieting; Deoli, Kanika; Huang, Tianda; Johnson, Alex; Ambani, Karina; Kim, Sangjun; Wang, Pulin; Coyle, Edward; Lu, Nanshu
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：Assessment of whole-body hydration (WBH) is crucial for health management and disease diagnosis. Traditional methods are invasive or require bulky equipment, making them impractical for mobile, continuous sensing. We present a wearable bioimpedance sensor with strategic electrode placement across the arm for noninvasive, continuous, and mobile WBH monitoring. Although whole-body bioimpedance is a proven method for indicating WBH, the effectiveness of local bioimpedance measurement has been unc...
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作者：Ling, Jing; Liu, Yitong; Dumoulin, Alexandre; Sheng, Danli; Fu, Yunzhe; Liu, Shuzhang; Ding, Ling; Huang, Lulu; Xi, Peng; Tang, Hongyun; Stoeckli, Esther T.; Chen, Zhixing
作者单位：Peking University; Peking University; University of Zurich; University of Zurich; Westlake University; Peking University; Peking University; Peking University; Peking University; University of Zurich; Chinese Academy of Sciences; Peking University
摘要：Plasma membrane (PM) stains are important organelle markers for monitoring membrane morphology and dynamics. The state-of-the-art PM stains are bright, specific, fluorogenic, and compatible with superresolution imaging. However, when recording membrane dynamics using advanced fluorescence microscopes, PM is prone to photo-dynamic damage introduced by dyes due to its phospholipid bilayer nature. Here, we introduce PK Mem dyes tailored for time-lapse fluorescence imaging. By integrating triplet-...
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作者：Rapuc, William; Guinoiseau, Damien; Arnaud, Fabien; Dellinger, Mathieu; Sabatier, Pierre; Gaillardet, Jerome; Poulenard, Jerome; Bouchez, Julien
作者单位：Universite Savoie Mont Blanc; Centre National de la Recherche Scientifique (CNRS); Durham University; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite Paris Saclay
摘要：Agropastoral activities have impacted the habitable part of our planet-the Critical Zone-for thousands of years, triggering a major increase in soil erosion in mountain environments. Understanding and quantifying the impact of these activities on soil is central to the well-being of our societies. Here, we investigate the isotope ratios of the trace element lithium in detrital sediments of Lake Bourget, European Alps, and provide a reconstruction of the impact of human activities on the evolut...
