29期

最新文章

• Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field AI翻译
  作者：Canoyra, Sara; Marin-Moreno, Alba; Espinosa, Juan Carlos; Fernandez-Borges, Natalia; Vidal, Enric; Orge, Leonor; Benestad, Sylvie L.; Andreoletti, Olivier; Torres, Juan Maria
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Instituto Nacional Investigacion Tecnologia Agraria Alimentaria (INIA); Complutense University of Madrid; IRTA; Autonomous University of Barcelona; Autonomous University of Barcelona; IRTA; University of Tras-os-Montes & Alto Douro; University of Tras-os-Montes & Alto Douro; Norwegian Veterinary Institute; INRAE
  摘要：Prion diseases can manifest with distinct phenotypes in a single species, a phenomenon known as prion strains. Upon cross-species transmission, alterations in the disease phenotype can occur, interpreted as the emergence of a new strain. Two main and non-mutually exclusive evolutionary hypotheses have been proposed to explain this phenomenon: the conformational shift or deformed templating and the conformational selection. The conformational shift hypothesis proposes that the introduction of a...
• How to design better incentives for carbon capture and storage in the United States AI翻译
  作者：Olmstead, Sheila M.; Leibowicz, Benjamin D.; Mason, Charles F.; Waxman, Andrew R.; Grubert, Emily; Rodriguez, H. R. Huber-; Stemmler, Joseph
  作者单位：Cornell University; Cornell University; Resources for the Future; University of Texas System; University of Texas Austin; University of Wyoming; University of Texas System; University of Texas Austin; University of Notre Dame; University of Oxford
• Amino acid coating enables micromotor operation in physiological conditions AI翻译
  作者：Sun, Jia; Ding, Yusen; Ye, Yicheng; Wang, Fei; Tian, Hao; Jiang, Jiamiao; Li, Huaan; Gao, Junbin; Tan, Haixin; Peng, Fei; Tang, Jinyao; Tu, Yingfeng
  作者单位：Southern Medical University - China; Southern Medical University - China; University of Hong Kong; Guangdong Pharmaceutical University; Guangdong Pharmaceutical University; Sun Yat Sen University
  摘要：Physiological environment with high ionic strength will quench the propulsion of micro/ nanomotors (MNMs) by suppressing electric double layers, especially for those motors based on electrolyte diffusiophoresis and electrophoresis. Herein, we demonstrate an efficient, general, and simple strategy to improve the ion tolerance of light-driven titanium dioxide (TiO2) micromotors with amino acid surface modification. Compared to the bare TiO2 counterpart, L-arginine (Arg)-treated TiO2 micromotors ...
• α- glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture AI翻译
  作者：Jacob, Anand; Willet, Alaina H.; Igarashi, Maya G.; El Nokab, Mustapha El Hariri; Turner, Lesley A.; Alsanad, Abdulrahman Khalid A.; Wang, Tuo; Gould, Kathleen L.
  作者单位：Michigan State University; Vanderbilt University
  摘要：Cell walls are critical structures of fungi, bacteria, and plants, providing mechanical strength, maintaining shape, and protecting cells from environmental stress. In alpha- 1,3- glucan chains essential for cell wall integrity, but how these chains are further assembled into mature polymers is not understood. Here, we identify two conserved glycosylphosphatidylinositol- anchored alpha- amylase- like enzymes, Aah1 and Aah3, which act redundantly as key contributors to alpha- glucan network for...
• Water content modulation enables selective ion transport in 2D MXene membranes AI翻译
  作者：Zhu, Yaguang; Xiong, Qinsi; Jeon, Woo Cheol; Blum, Monika; Camino, Fernando; Schatz, George C.; Hatzell, Kelsey B.
  作者单位：Princeton University; Northwestern University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory; Princeton University
  摘要：Separation membranes are critical for a range of processes, including but not limited to water desalination, chemical and fuel production, and recycling and recovery applications. Fundamentally, there are intrinsic trade-offs between permeability and selectivity. Local water organization and content can impact membrane structure and impact selective ion permeation. Intercalation of chaotropic cesium (Cs+) ions within the layers reduces the water content in the membrane and at the surface which...
• mtKO: A dedicated guide RNA library for mitochondria research AI翻译
  作者：Kaur, Karambir; Zaheer, Javeria; Lang, Fengchao; Ribeiro, Diego Luis; Zhang, Meili; Song, Hua; Zhang, Wei; Chari, Raj; Alkaissi, Hussam; Yang, Chunzhang
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  摘要：Mitochondria are multifunctional organelles central to both physiological and pathological processes. In malignant cancer cells, mitochondrial reprogramming establishes the metabolic foundation to meet cellular demands, which is particularly important in tumor cells with existing metabolic perturbations. To identify key mitochondrial pathways supporting cancer development, we developed mitochondria Knockout (mtKO), a robust and unbiased CRISPR screening platform to pinpoint critical mitochondr...
• Sleeping upside- down: Knockdown of a sleep- associated gene induces daytime sleep in the jellyfish Cassiopea AI翻译
  作者：Abrams, Michael J.; Ohdera, Aki; Francis, Diana A.; Donayre, Owen; Chen, Henry; Lu, Kevin; Hsu, Celeste Y.; Zeigler, Hannah; Harland, Richard M.
  作者单位：University of California System; University of California Berkeley; University of Arizona
  摘要：The conservation of sleep among diverse animals provides clear evidence for its physiological importance, but the extent of its regulatory conservation is unknown. The upside-down jellyfish Cassiopea xamachana sleeps, and this behavior is controlled by radially spaced marginal ganglia. After defining a sleep-wake threshold, we compared gene expression profiles of ganglia from animals deprived of sleep and found differential expression in many sleep-related genes including GABAergic, melatonerg...
• Structures of Chaetomium thermophilum TOM complexes with bound preproteins AI翻译
  作者：Agip, Ahmed-Noor A.; Ornelas, Pamela; Yang, Tzu-Jing; Uboldi, Ermanno; Haeder, Sabine; McDowell, Melanie A.; Kuehlbrandt, -Werner
  作者单位：Max Planck Society; Max Planck Society
  摘要：Mitochondria import most of their proteins from the cytoplasm through the TOM complex. Preproteins containing targeting signals are recognized by the TOM receptor subunits and translocated by Tom40 across the outer mitochondrial membrane. We present four structures of the preprotein- bound and preprotein- free TOM core and holo complexes from the thermophilic fungus Chaetomium thermophilum, obtained by single- particle electron cryomicroscopy. Our structures reveal the symmetric arrangement of...
• Surface tension between coexisting phases of active Brownian particles AI翻译
  作者：Li, Longfei; Sun, Zihao; Yang, Mingcheng
  作者单位：Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：The confliction between the stable interface in phase-separated active Brownian particles and its negative surface tension, obtained mechanically via the active pressure, has sparked considerable debate about the formula of active surface tension. Based on the intrinsic pressure of active system, we here derive a mechanical expression of active surface tension by calculating the work required to create a differential interface area, while remaining the interfacial profiles of intensive quantit...
• Explaining and predicting the Southern Hemisphere eddy-driven jet AI翻译
  作者：Mindlin, Julia; Shepherd, Theodore G.; Osma, Marisol; Vera, Carolina S.; Kretschmer, Marlene; Marengo, Jose A.
  作者单位：University of Reading; Helmholtz Association; Research Center Julich; University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
  摘要：The summertime eddy-driven jet (EDJ) in the Southern Hemisphere is a critical mediator between regional climate and large-scale phenomena, guiding synoptic systems that shape weather patterns. Uncertainties in global climate models (GCMs)-particularly in projecting changes in remote drivers like tropical warming, stratospheric polar vortex strengthening, and asymmetric tropical Pacific warming-hinder predictions of EDJ trends and associated regional outcomes. In this study, we develop a causal...