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作者：Dong, Zhen; Sepulveda, Hugo; Arteaga-Vazquez, Leo J.; Blouin, Chad; Fernandez, Jenna; Binder, Moritz; Chou, Wen-Chien; Tien, Hwei-Fang; Patnaik, Mrinal M.; Faulkner, Geoffrey J.; Myers, Samuel A.; Rao, Anjana
作者单位：La Jolla Institute for Immunology; University of California System; University of California San Diego; Universidad Andres Bello; Universidad Andres Bello; Mayo Clinic; National Taiwan University; National Taiwan University Hospital; University of Queensland; Mater Research; University of Queensland
摘要：ASXL transcriptional regulator 1 (ASXL1) is one of the three most frequently mutated genes in age- related clonal hematopoiesis (CH), alongside DNA methyltransferase 3 alpha (DNMT3A) and Tet methylcytosine dioxygenase 2 ( TET2) . CH can progress to myeloid malignancies including chronic monomyelocytic leukemia (CMML) and is also strongly associated with inflammatory cardiovascular disease and all- cause mortality in humans. DNMT3A and TET2 regulate DNA methylation and demethylation pathways, r...
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作者：Li, Chu; Yao, Yuan; Pan, Ding
作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
摘要：Dissolution of CO2 in water followed by the subsequent hydrolysis reactions is of great importance to the global carbon cycle, and carbon capture and storage. Despite numerous previous studies, the reactions are still not fully understood at the atomistic scale. Here, we combined ab initio molecular dynamics (AIMD) simulations with Markov state models to elucidate the reaction mechanisms and kinetics of CO2 in supercritical water both in the bulk and nanoconfined states. The integration of uns...
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作者：Mugo, Andrew Njagi; Chou, Ryan; Qin, Feng
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; Duke University; Duke University
摘要：Ion channels are generally allosteric proteins, involving specialized stimulus sensor domains conformationally linked to the gate to drive channel opening. Temperature receptors are a group of ion channels from the transient receptor potential family. They exhibit an unprecedentedly strong temperature dependence and are responsible for temperature sensing in mammals. Despite intensive studies, however, the nature of the temperature sensor domain in these channels remains elusive. By direct cal...
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作者：Tucci, Frank J.; Rosenzweig, Amy C.
作者单位：Northwestern University; Northwestern University
摘要：Methane- and ammonia- oxidizing bacteria play key roles in the global carbon and nitrogen cycles, respectively. These bacteria use homologous copper membrane monooxygenases to accomplish the defining chemical transformations of their metabolisms: the oxidations of methane to methanol by particulate methane monooxygenase (pMMO) and ammonia to hydroxylamine by ammonia monooxygenase (AMO), enzymes of prime interest for applications in mitigating climate change. However, investigations of these en...
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作者：Wang, Kui; Zhao, Hongjian; Liu, Guangtao; Zhou, Mi; Chen, Yinqi; Li, Qiushi; Ma, Guangchen; Wang, Hongbo; Hemley, Russell J.; Ma, Yanming
作者单位：Jilin University; Jilin University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Jilin University
摘要：The abrupt drop of resistance to zero at a critical temperature is a key signature of the current paradigm of the metal-superconductor transition. However, the emergence of an intermediate bosonic insulating state characterized by a resistance peak preceding the onset of the superconducting transition has challenged this traditional understanding. Notably, this phenomenon has been predominantly observed in disordered or chemically doped low- dimensional systems, raising intriguing questions ab...
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作者：Yin, Ruoyu; Wang, Qingyuan; Tornow, Sabine; Barkai, Eli
作者单位：Bar Ilan University; Bundeswehr University Munich
摘要：We introduce a time-energy uncertainty relation within the context of restarts in monitored quantum dynamics. Previous studies have established that the mean recurrence time, which represents the time taken to return to the initial state, is quantized as an integer multiple of the sampling time, displaying pointwise discontinuous transitions at resonances. Our findings demonstrate that the natural utilization of the restart mechanism in laboratory experiments, driven by finite data collection ...
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作者：Dreyer, Tabea; Haluts, Amir; Korman, Amos; Gov, Nir; Fonio, Ehud; Feinerman, Ofer
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; University of Haifa
摘要：Biological ensembles use collective intelligence to tackle challenges together, but suboptimal coordination can undermine the effectiveness of group cognition. Testing whether collective cognition exceeds that of the individual is often impractical since different organizational scales tend to face disjoint problems. One exception is the problem of navigating large loads through complex environments and toward a given target. People and ants stand out in their ability to efficiently perform th...
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作者：Karatayev, Vadim A.; Munch, Stephan B.; Rogers, Tanya L.; Reuman, Daniel C.
作者单位：University System of Maryland; University of Maryland College Park; University of Kansas; University of Kansas; National Oceanic Atmospheric Admin (NOAA) - USA; University of California System; University of California Santa Cruz
摘要：Climate change is increasing the frequency of large- scale, extreme environmental events and flattening environmental gradients. Whether such changes will cause spatially synchronous, large- scale population declines depends on mechanisms that limit metapopulation synchrony, thereby promoting rescue effects and stability. Using long- term data and empirical dynamic models, we quantified spatial heterogeneity in density dependence, spatial heterogeneity in environmental responses, and environme...
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作者：Sclocchi, Antonio; Favero, Alessandro; Wyart, Matthieu
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Understanding the structure of real data is paramount in advancing modern deep- learning methodologies. Natural data such as images are believed to be composed of features organized in a hierarchical and combinatorial manner, which neural networks capture during learning. Recent advancements show that diffusion models can generate high-quality images, hinting at their ability to capture this underlying compositional structure. We study this phenomenon in a hierarchical generative model of data...
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作者：Wirt, Jonah L.; Ferreira, Luana Assis; Jesus, Carlos Henrique Alves; Woodward, Taylor J.; Oliva, Idaira; Xu, Zhili; Crystal, Jonathon D.; Pepin, Robert H.; Silverman, Richard B.; Hohmann, Andrea G.
作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Indiana University System; Indiana University Bloomington
摘要：Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement of GABAergic transmission represents a potential analgesic strategy. However, therapeutic potential of current GABA agonists and modulators is limited by unwanted side effects. We postulated that inhibition of GABA's degradation enzyme, GABA aminotransferase (GABA-AT), would increase endogenous GABA levels and produce analgesia. We evaluated antinociceptive efficacy of the potent GABA-AT inhib...
