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作者：Chivukula, Srinivas; Aflalo, Tyson; Zhang, Carey; Rosario, Emily R.; Bari, Ausaf; Pouratian, Nader; Andersen, Richard A.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; California Institute of Technology; California Institute of Technology; University of California System; University of California Los Angeles
摘要：Cognition relies on transforming sensory inputs into a generalizable understanding of the world. Mirror neurons have been proposed to underlie this process, mapping visual representations of others' actions and sensations onto neurons that mediate our own, providing a conduit for understanding. However, this theory has limitations. Here, we hypothesize that mirror- like responses represent one facet of a broader framework in which our brains engage internal models for cognition. We recorded po...
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作者：Li, Cong; Li, Minglai; Zhang, Lin; Li, Qiang; Zheng, Hua; Feldman, Marcus W.
作者单位：Xi'an Jiaotong University; City University of Hong Kong; City University of Hong Kong; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Stanford University
摘要：Affordable and clean energy, eliminating poverty, and reducing inequality are important goals of the United Nations Sustainable Development Goals (SDGs). This paper examines the role of access to clean cooking fuels in promoting income growth and reducing income inequality. Using data from Chinese households, we show that a 10% increase in the adoption of clean cooking fuels would result in an increase in total annual household income of US$37 billion nationwide. Income growth from access to c...
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作者：Wang, Jun; Liao, Long; Miao, Beiping; Yang, Bo; Li, Botai; Ma, Xuhui; Fitz, Annika; Wu, Shanshan; He, Jia; Zhang, Qianqian; Ji, Shuyi; Jin, Guangzhi; Zhang, Jianming; Cao, Ying; Wang, Hui; Qin, Wenxin; Sun, Chong; Bernardsa, Rene; Wang, Cun
作者单位：Shanghai Jiao Tong University; Helmholtz Association; German Cancer Research Center (DKFZ); Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shanghai Jiao Tong University; Netherlands Cancer Institute; Tongji University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Netherlands Cancer Institute
摘要：Ferroptosis, a unique form of iron- dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role of GPX4 in regulating ferroptosis, our understanding of GPX4 protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as a regulator of GPX4 protein. Inhibition of MALT1 expression enhances GPX4 ubiquitination- mediated degradation by up- regulating the E3 ubiquitin ligase RC3H1. U...
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作者：Yardeni, Tal; Olali, Arnold Z.; Chen, Hsiao-Wen; Wang, Liqing; Halton, Jeffrey A.; Zenab, Angi; Morrow, Ryan; Butic, Arrienne; Murdock, Deborah G.; Waymire, Katrina G.; Macgregor, Grant R.; Boursi, Ben; Beier, Ulf H.; Hancock, Wayne W.; Wallace, Douglas C.
作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Chaim Sheba Medical Center; Tel Aviv University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of California System; University of California Irvine; Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University; University of Pennsylvania
摘要：Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA- cancer association, we analyzed conplastic mice with the C57BL/6J (B6) nucleus but two naturally occurring mtDNA lineages, mtDNAB6 and mtDNANZB, where mtDNANZB mitochondria generate more oxidative phosphorylation (OXPHOS)- derived reactive oxygen species (mROS). In a cardiac transplant model, mtDNAB6Foxp3+ T regulatory (Treg) cells su...
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作者：Galstyan, Vahe; ten Wolde, Pieter Rein
作者单位：AMOLF
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作者：Jeon, Byoung-jin; Guareschi, Matteo M.; Stewart, Jaimie Marie; Wu, Emily; Gopinath, Ashwin; Arroyo-Curras, Netzahualcoyotl; Dauphin-Ducharme, Philippe; Plaxco, Kevin W.; Lukeman, Philip S.; Rothemund, Paul W. K.
作者单位：California Institute of Technology; University of California System; University of California Los Angeles; Massachusetts Institute of Technology (MIT); Johns Hopkins University; University of Sherbrooke; University of California System; University of California Santa Barbara; St. John's University
摘要：The diversity and heterogeneity of biomarkers has made the development of general methods for single- step quantification of analytes difficult. For individual biomarkers, electrochemical methods that detect a conformational change in an affinity binder upon analyte binding have shown promise. However, because the conformational change must operate within a nanometer- scale working distance, an entirely new sensor, with a unique conformational change, must be developed for each analyte. Here, ...
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作者：Zhang, Yuxi; Mackinnon, Roderick
作者单位：Rockefeller University; Howard Hughes Medical Institute; Rockefeller University
摘要：We examine the role of higher- order transient structures (HOTS) in M2R regulation of GIRK channels. Electron microscopic membrane protein location maps show that both proteins form HOTS that exhibit a statistical bias to be near each other. Theoretical calculations and electrophysiological measurements suggest that channel activity is isolated near larger M2R HOTS. By invoking weak interactions that permit transient binding of M2R to M2R and GIRK to GIRK ( i-i interactions) and M2R to GIRK ( ...
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作者：Zhang, Yuxin; Tu, Chengjie; Bai, Jianyang; Li, Xiayu; Sun, Ziyue; Xu, Letian
作者单位：Hubei University; Anhui Agricultural University
摘要：Horizontal gene transfer (HGT) from bacteria to insects is widely reported and often associated with the adaptation and diversification of insects. However, compelling evidence demonstrating how HGT- conferred metabolic adjustments enable species to adapt to surrounding environment remains scarce. Dietary specialization is an important ecological strategy adopted by animals to reduce inter- and intraspecific competition for limited resources. Adults of the leaf beetle Plagiodera versicolora (C...
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作者：Gao, Yining; Tao, Yong; Li, Gen; Shen, Peiliang; Pellenq, Roland J. M.; Poon, Chi Sun
作者单位：Hong Kong Polytechnic University; Hong Kong Polytechnic University; Ecole nationale superieure de chimie de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite de Montpellier
摘要：CO2 mineralization, a process where CO2 reacts with minerals to form stable carbonates, presents a sustainable approach for CO2 sequestration and mitigation of global warming. While the crucial role of water in regulating CO2 mineralization efficiency is widely acknowledged, a comprehensive understanding of the underlying mechanisms remains elusive. This study employs a combined experimental and atomistic simulation approach to elucidate the intricate mechanisms governing moisture- driven carb...
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作者：Riddell, Brennan; Mcdonough, Molly; Ferguson, Adam; Kimani, John M.; Gawriluk, Thomas R.; Peng, Chi; Kiama, Stephen G.; Ezenwa, Vanessa O.; Seifert, Ashley W.
作者单位：University of Kentucky; Chicago State University; Field Museum of Natural History (Chicago); University of Nairobi; University of Kentucky; Yale University
摘要：Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed represent cases of convergent evolution or are instead the product of phylogenetic inertia from a common ancestral program. Testing alternative hypotheses to identify genetic regulation, cell states, and tissue physiology that explain how regenerative healing emerges in some species requires sampling...
