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• Deletion of metal transporter Zip14 reduces major histocompatibility complex II expression in murine small intestinal epithelial cells AI翻译
  作者：Jimenez-Rondan, Felix R.; Ruggiero, Courtney H.; Riva, Alberto; Yu, Fahong; Stafford, Lauren S.; Cross, Tyler R.; Larkin III, Joseph; Cousins, Robert J.
  作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
  摘要：by J. accepted by Documented worldwide, impaired immunity is a cardinal signature resulting from loss of dietary zinc, an essential micronutrient. A steady supply of zinc to meet cellular requirements is regulated by an array of zinc transporters. Deletion of the transporter Zip14 (Slc39a14) in mice produced intestinal inflammation. Elevated fecal lipocalin-2, calprotectin, IgG levels, and dysbiosis support the inflammatory phenotype. Here, we show through RNA-sequencing, using purified intest...
• X*Y females exhibit steeper reproductive senescence in the African pygmy mouse AI翻译
  作者：Lemaitre, Jean-Francois; Voituron, Yann; Herpe, Lea; Veyrunes, Frederic
  作者单位：Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; CNRS - Institute of Ecology & Environment (INEE); University of Moncton; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier
  摘要：A wave of studies has recently emphasized the influence of sex chromosomes on both lifespan and actuarial senescence patterns across vertebrates and invertebrates. Basically, the heterogametic sex (XY males in XX/XY systems or ZW females in ZW/ZZ systems) typically displays a lower lifespan and a steeper rate of actuarial senescence than the homogametic sex. However, whether these effects extend to the senescence patterns of other phenotypic traits or physiological functions is yet to be deter...
• The proteome is a terminal electron acceptor AI翻译
  作者：Flamholz, Avi, I; Goyal, Akshit; Fischer, Woodward W.; Newman, Dianne K.; Phillips, Rob
  作者单位：California Institute of Technology; Massachusetts Institute of Technology (MIT); Tata Institute of Fundamental Research (TIFR); International Centre for Theoretical Sciences, Bengaluru; California Institute of Technology; California Institute of Technology
  摘要：Microbial metabolism is impressively flexible, enabling growth even when available nutrients differ greatly from biomass in redox state. Escherichia coli, for example, rearranges its physiology to grow on reduced and oxidized carbon sources through several forms of fermentation and respiration. To understand the limits on and evolutionary consequences of this metabolic flexibility, we developed a coarse-grained mathematical framework coupling redox chemistry with principles of cellular resourc...
• Pseudogap in electron-doped cuprates: Strong correlation leading to band splitting AI翻译
  作者：Horio, Masafumi; Sakai, Shiro; Suzuki, Hakuto; Nonaka, Yosuke; Hashimoto, Makoto; Lu, Donghui; Shen, Zhi-Xun; Ohgi, Taro; Konno, Takuya; Adachi, Tadashi; Koike, Yoji; Imada, Masatoshi; Fujimori, Atsushi
  作者单位：University of Tokyo; University of Tokyo; RIKEN; Tohoku University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Tohoku University; Sophia University; Waseda University; National Tsing Hua University
  摘要：The pseudogap phenomena have been a long-standing mystery of the cuprate high- temperature superconductors. The pseudogap in the electron-doped cuprates has been attributed to band folding due to antiferromagnetic (AFM) long-range order or shortrange correlation. We performed an angle-resolved photoemission spectroscopy study of the electron-doped cuprates Pr1.3-xLa0.7CexCuO4 showing spin-glass, disordered AFM behaviors, and superconductivity at low temperatures and, by measurements with fine ...
• Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae AI翻译
  作者：Mahoney, Brendan J.; Lyman, Lindsey R.; Ford, Jordan; Soule, Jess; Cheung, Nicole A.; Goring, Andrew K.; Ellis-Guardiola, Kat; Collazo, Michael J.; Cascio, Duilio; Ton-That, Hung; Schmitt, Michael P.; Clubb, Robert T.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; US Food & Drug Administration (FDA); Center for Biologics Evaluation & Research (CBER); University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin. Corynebacterium diphtheriae causes the life- threatening respiratory disease diphtheria and captures hemoglobin for iron scavenging using the surface- displayed receptor HbpA. Here, we show using X- ray crystallography, NMR, and in situ binding measurements that C. diphtheriae selectively captures iron- loaded hemoglobin by partially ensconcin...
• Liquid- nano- liquid interface-oriented anisotropic encapsulation AI翻译
  作者：Zhan, Yating; Huang, Xirui; Liu, Minchao; Lin, Runfeng; Yu, Hongyue; Kou, Yufang; Xing, Enyun; Elzatahry, Ahmed A.; Mady, Mohamed F.; Zhao, Dongyuan; Zhao, Tiancong; Li, Xiaomin
  作者单位：Fudan University; University of Houston System; University of Houston; Qatar University
  摘要：Emulsion interface engineering has been widely employed for the synthesis of nanomaterials with various morphologies. However, the instability of the liquid-liquid interface and uncertain interfacial interactions impose significant limitations on controllable fabrications. Here, we developed a liquid- nano- liquid interface-oriented anisotropic encapsulation strategy for fabricating asymmetric nanohybrids. Specifically, functional nanoparticles such as magnetic nanoparticles, lanthanide fluore...
• Collaborative management partnerships strongly decreased deforestation in the most at-risk protected areas in Africa since 2000 AI翻译
  作者：Desbureaux, Sebastien; Kabore, Ibrahim; Vaglietti, Giulia; Baghai, Mujon; Lindsey, Peter; Robson, Ashley; Delacote, Philippe; Leblois, Antoine
  作者单位：INRAE; Universite de Montpellier; Institut Agro; Centre National de la Recherche Scientifique (CNRS); Universite Le Havre Normandie; Fondazione Mattei; Universite de Lorraine; AgroParisTech; INRAE; University of Cape Town
  摘要：Collaborative management partnerships (CMPs) between state wildlife authorities and nonprofit conservation organizations to manage protected areas (PAs) have been used increasingly across Sub-Saharan Africa since the 2000s. They aim to attract funding, build capacity, and increase the environmental effectiveness of PAs. Our study documents the rise of CMPs, examines their current extent, and measures their effectiveness in protecting habitats. We combine statistical matching and Before-AfterCo...
• Memory control deficits in the sleep- deprived human brain AI翻译
  作者：Harrington, Marcus O.; Karapanagiotidis, Theodoros; Phillips, Lauryn; Smallwood, Jonathan; Anderson, Michael C.; Cairney, Scott A.
  作者单位：University of York - UK; University of East Anglia; University of Sussex; Queens University - Canada; University of Cambridge; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of York - UK
  摘要：Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted ...
• Nocturnal camouflage through background matching against moonlight AI翻译
  作者：Negro, Juan J.; Bara, Salvador; Galadi-Enriquez, David; Nieves, Juan Luis; Martinez-Domingo, Miguel A.; Ferrero, Alejandro; Campos, Joaquin; Bao-Varela, Carmen; Masana, Eduard; Camacho, Carlos
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Universidad de Cordoba; University of Granada; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Optica (Daza de Valdes); Universidade de Santiago de Compostela; University of Barcelona; University of Barcelona; Institut d'Estudis Espacials de Catalunya (IEEC)
  摘要：Camouflage is often considered a daytime phenomenon based on light and shade. Nocturnal camouflage can also occur, but its mechanistic basis remains unclear. Here, we analyze the conditions for background matching (BM) of avian predators against the night sky. Such concealment is achieved when the contrast between the predator and the sky is smaller than the contrast detection threshold of prey. This condition cannot be fulfilled under isotropic skies, as in fully overcast or moonless nights. ...
• Unlocking the catalytic precision of ligand- controlled enzymatic halogenation AI翻译
  作者：Phintha, Aisaraphon; Lukowski, April L.; Chaiyen, Pimchai
  作者单位：Vidyasirimedhi Institute of Science & Technology; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California San Diego
  摘要：A single-component flavin-dependent halogenase, AetF, has emerged as an attractive biocatalyst for catalyzing halogenation. However, its flavin chemistry remains unexplored and cannot be predicted due to its uniqueness in sequence and structure compared to other flavin-dependent monooxygenases. Here, we investigated the flavin reactions of AetF using transient kinetics. Our data revealed that NADP(+) binding is required for formation of C4a-hydroperoxy flavin adenine dinucleotide (FAD) (FAD(C4...