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作者：Schloesser, Stefan; Ullrich, Anna-Lena; Modares, Nastaran Fazel; Schmitz, Matthias A.; Schoeneich, Johannes; Zhang, Kaiyi; Richter, Isabel; Robrahn, Laura; Schraven, Sarah; Nagai, James S.; Haange, Sven-Bastiaan; Jennings, Susan A. V.; Clavel, Thomas; Rolle-Kampczyk, Ulrike; Kiessling, Fabian; Costa, Ivan G.; Muncan, Vanesa; Repnik, Urska; von Bergen, Martin; Dupont, Aline; Hornef, Mathias W.
作者单位：RWTH Aachen University; RWTH Aachen University Hospital; Hannover Medical School; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; University of Kiel; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
摘要：Postnatal establishment of enteric metabolic, host-microbial and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Here, we show that infection with the invasive enteropathogen Salmonella Typhimurium results in accelerated maturation of the neonatal epithelium with premature appearance of antimicrobial, metabolic, developmental, and regenerative features of the adult tissue. Using conditional Myd88- deficient mice, we identify the c...
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作者：Zhou, Lili; Miller, Caitlyn; Miraglia, Loren J.; Romero, Angelica; Xu, Shunbin; Mure, Ludovic S.; Panda, Satchidananda; Kay, Steve A.
作者单位：University of Southern California; Novartis; Novartis USA; Wayne State University; Salk Institute
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作者：Clauss, Marcus; Roller, Marco; Bertelsen, Mads Frost; Rohr, Claudia Rudolf von; Mueller, Dennis W. H.; Schiffmann, Christian; Kummrow, Maya; Encke, Dag; Ferreira, Sam; Duvall, Ethan S.; Mare, Celeste; Abraham, Andrew J.
作者单位：University of Zurich; University of Copenhagen; North West University - South Africa; Cornell University; Aarhus University; Northern Arizona University
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作者：Havermark, Tora; Metelev, Mikhail; Lundin, Erik; Volkov, Ivan L.; Johansson, Magnus
作者单位：Uppsala University
摘要：The bacterial chaperone Trigger factor (TF) binds to ribosome- nascent chain complexes (RNCs) and cotranslationally aids the folding of proteins in bacteria. Decades of studies have given a broad, but often conflicting, description of the substrate specificity of TF, its RNC- binding dynamics, and competition with other RNC- binding factors, such as the Signal Recognition Particle (SRP). Previous RNC- binding kinetics experiments were commonly conducted on stalled RNCs in reconstituted systems...
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作者：Liu, Junyi; Zhang, Xu; Lu, Gang
作者单位：California State University System; California State University Northridge
摘要：Moir & eacute; excitons and moir & eacute; magnetism are essential to semiconducting van der Waals magnets. In this work, we perform a comprehensive first- principles study to elucidate the interplay of electronic excitation and magnetism in twisted magnetic CrSBr bilayers. We predict a twist- induced quantum phase transition for interlayer magnetic coupling and estimate the critical twist angle below which moir & eacute; magnetism with mixed ferromagnetic and antiferromagnetic domains could e...
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作者：Agam, Oded; Braun, Erez
作者单位：Hebrew University of Jerusalem; Technion Israel Institute of Technology
摘要：Animal morphogenesis, the development of an organism's body form, is commonly perceived as a directed and almost deterministic process. However, noise and stochastic fluctuations are ubiquitous in biological systems. The questions on the role of fluctuations in morphogenesis and what ensures the robustness of this process under noisy conditions remain elusive. Here, we utilize Hydra regeneration, subjected to an external electric field, to provide unique insights into these questions. We found...
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作者：Boisseau, Romain P.; Bradler, Sven; Emlen, Douglas J.
作者单位：University of Montana System; University of Montana; University of Lausanne; University of Gottingen
摘要：Independent evolution of similar traits in lineages inhabiting similar environments (convergent or repeated evolution) is often taken as evidence for adaptation by natural selection, and used to illustrate the predictability of evolution. Yet convergence is rarely perfect for two reasons. First, environments may not be as similar as they appear. Second, responses to selection are contingent upon available genetic variation and independent lineages may differ in the alleles, genetic backgrounds...
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作者：de Armas, Yadira Chinique; Godoy, Silvia Teresita Hernandez; Sanfiel, Luis M. Viera; Buhay, William M.; Laffoon, Jason E.
作者单位：University of Winnipeg; Leiden University - Excl LUMC; Leiden University; Vrije Universiteit Amsterdam
摘要：The early populations that inhabited the Antilles were traditionally understood as highly mobile groups of hunters/fishers and gatherers. Although more recent data have demonstrated that some populations engaged in the production of domestic plants and cultivars, questions remain about other aspects of their lifeways, including whether the adoption of domesticates was accompanied by a decrease in residential mobility. The level of sedentism in a population is an instrumental variable to unders...
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作者：Jaczynska, Klaudia; Esser, Victoria; Xu, Junjie; Sari, Levent; Lin, Milo M.; Rosenmund, Christian; Rizo, Josep
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin
摘要：Neurotransmitter release is triggered in microseconds by Ca2+- binding to the dles between synaptic vesicles and plasma membranes, but the coupling mechanism between Ca2+- sensing and membrane fusion is unknown. Release requires extension of SNARE helices into juxtamembrane linkers that precede transmembrane regions (linker through a primary interface comprising two regions (I and II). The Synaptotagmin- 1 curvature, perturbing lipid bilayers, or helping bridge the membranes, but SNARE from th...
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作者：Mills, Carolyn E.
作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
