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作者：Lentz, David L.; Pohl, Mary E. D.
作者单位：University System of Ohio; University of Cincinnati; State University System of Florida; Florida State University
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作者：Amarasinghe, Piyumi R.; Allison, Lloyd; Morton, Craig J.; Stuckey, Peter J.; de la Banda, Maria Garcia; Lesk, Arthur M.; Konagurthu, Arun S.
作者单位：Monash University; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：As structural biology and drug discovery depend on high-quality protein structures, assessment tools are essential. We describe a new method for validating amino-acid conformations: PhiSiCal ( tpyix al) Checkup. Twenty new joint probability distributions in the form of statistical mixture models explain the empirical distributions of dihedral angles (0), tp , yi , x 1 , x 2 , ...) of canonical amino acids in experimental protein structures. Marginal and conditional probability distributions fo...
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作者：Hankel, Camille
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：The Atlantic Meridional Overturning Circulation (AMOC) is a key component of the global climate that is projected to weaken under future anthropogenic climate change. While many studies have investigated the AMOC's response to different levels and types of forcing in climate models, relatively little attention has been paid to the AMOC's sensitivity to the rate of forcing change, despite it also being highly uncertain in future emissions scenarios. In this study, I isolate the AMOC's response ...
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作者：Nyenhuis, David A.; Watanabe, Susan M.; Tjandra, Nico; Carter, Carol A.
作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital
摘要：Tsg101 is a highly conserved protein best known as an early- functioning component of cellular ESCRT machinery participating in recognition, sorting, and trafficking of cellular cargo to various intracellular destinations. It shares sequence and structural homology to canonical ubiquitin- conjugating (E2) enzymes and is linked to diverse events regulated by Ub signaling. How it might fulfill these roles is unclear. Here, we show that Tsg101 E2 mimicry permits interactions with diverse ubiquiti...
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作者：Borjigin, Agudemu; Bharadwaj, Hari M.
作者单位：Purdue University System; Purdue University; University of Wisconsin System; University of Wisconsin Madison; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：to and precisely follow very fast cycle-by-cycle fluctuations in the phase of sounddriven cochlear vibrations. Yet, the perceptual role of this temporal fine structure experimentally manipulate TFS cues without altering other perceptually relevant cues. Here, we circumnavigated this limitation by leveraging individual differences across 200 participants to systematically compare variations in TFS sensitivity to performance in a range of speech perception tasks. TFS sensitivity was assessed thr...
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作者：Hatkevich, Talia; Tezak, Boris M.; Acemel, Rafael D.; Chung, Vicky Wai Yee; Lupianez, Dario G.; Capel, Blanche
作者单位：Duke University; Wesleyan University; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD)
摘要：In species with genetic sex determination (GSD), the sex identity of the soma determines germ cell fate. For example, in mice, XY germ cells that enter an ovary differentiate as oogonia, whereas XX germ cells that enter a testis initiate differentiation as spermatogonia. However, numerous species lack a GSD system and instead display temperature- dependent sex determination (TSD). In the red- eared slider turtle, Trachemys scripta, a TSD model species with a warm female promoting temperature (...
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作者：Perkins, Mindy Liu; Crocker, Justin; Tkacik, Gasper
作者单位：European Molecular Biology Laboratory (EMBL); Institute of Science & Technology - Austria
摘要：Biophysical constraints limit the specificity with which transcription factors (TFs) can target regulatory DNA. While individual nontarget binding events may be low affinity, the sheer number of such interactions could present a challenge for gene regulation by degrading its precision or possibly leading to an erroneous induction state. Chromatin can prevent nontarget binding by rendering DNA physically inaccessible to TFs, at the cost of energy-consuming remodeling orchestrated by pioneer fac...
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作者：Qin, Chun; Yang, Bao; Braeuning, Achim; Ljungqvist, Fredrik Charpentier; Osborn, Timothy J.; Shishov, Vladimir; He, Minhui; Kang, Shuyuan; Schneider, Lea; Esper, Jan; Buentgen, Ulf; Griessinger, Jussi; Huang, Danqing; Zhang, Peng; Talento, Stefanie; Xoplaki, Elena; Luterbacher, Juerg; Stenseth, Nils Chr.
作者单位：Chinese Academy of Sciences; Nanjing University; University of Erlangen Nuremberg; Stockholm University; Stockholm University; Swedish Collegium for Advanced Study (SCAS); University of East Anglia; Siberian Federal University; Justus Liebig University Giessen; Johannes Gutenberg University of Mainz; Czech Academy of Sciences; Global Change Research Centre of the Czech Academy of Sciences; University of Cambridge; Masaryk University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Salzburg University; Nanjing University; University of Oslo
摘要：The Qin and Western Han dynasties (221 BCE to 24 CE) represent an era of societal prosperity in China. However, due to a lack of high- resolution paleoclimate records it is still unclear whether the agricultural boost documented for this period was associated with more favorable climatic conditions. Here, multiparameter analysis of annually resolved tree- ring records and process- based physiological modeling provide evidence of stable and consistently humid climatic conditions during 270 to 7...
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作者：Shi, Wenpeng; Yi, Xiaogui; Ruan, Hua; Wang, Donglei; Wu, Dan; Jiang, Pengfei; Luo, Lisha; Ma, Xirui; Jiang, Faming; Li, Cairui; Wu, Weinan; Luo, Lingfei; Li, Li; Wang, Guixue; Qiu, Juhui; Huang, Honghui
作者单位：Chongqing University; Southwest University - China; Chinese Academy of Sciences; Chongqing Institute of Green & Intelligent Technology, CAS; Dali University; Guangdong Medical University; Guangdong Medical University
摘要：Heterozygotic GATA6 mutations are responsible for various congenital diseases in the heart, pancreas, liver, and other organs in humans. However, there is lack of an animal that can comprehensively model these diseases since GATA6 is essential for early embryogenesis. Here, we report the establishment of a gata6 knockout zebrafish which recapitulates most of the symptoms in patients with GATA6 mutations, including cardiac outflow tract defects, pancreatic hypoplasia/agenesis, gallbladder agene...
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作者：Zhang, Fan; Chen, Shanshan; Zhang, Can; Wang, Zhiwen; Miao, Jianqiang; Dai, Tan; Hao, Jianjun; Liu, Xili
作者单位：China Agricultural University; Northwest A&F University - China; University of Maine System; University of Maine Orono
摘要：Host plants and various fungicides inhibit plant pathogens by inducing the release of excessive reactive oxygen species (ROS) and causing DNA damage, either directly or indirectly leading to cell death. The mechanisms by which the oomycete Phytophthora sojae manages ROS stress resulting from plant immune responses and fungicides remains unclear. This study elucidates the role of histone acetylation in ROS- induced DNA damage responses (DDR) to adapt to stress. Mechanistically, the P. sojae DNA...
