2期

最新文章

• Splenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand AI翻译
  作者：Kaestner, Lars; Egee, Stephane; Connes, Philippe; Bogdanova, Anna Yu.; Simmonds, Michael J.
  作者单位：Universitatsklinikum des Saarlandes; Saarland University; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Sorbonne Universite; Universite Claude Bernard Lyon 1; University of Zurich; Griffith University; Griffith University - Gold Coast Campus
• A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells AI翻译
  作者：Qin, Gege; Shao, Xiying; Liu, Xiaolong; Xu, Jiachao; Wang, Xiaojia; Wang, Wenxi; Gao, Lu; Liang, Yuxin; Xie, Lina; Su, Dan; Yang, Hongwei; Zhou, Wei; Fang, Xiaohong
  作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS; Tsinghua University; Zhejiang Cancer Hospital; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS
  摘要：Emerging evidence indicates that intratumor bacteria exist as an active and specific tumor component in many tumor types beyond digestive and respiratory tumors. However, the biological impact and responsible molecules of such local bacteria-tumor direct interaction on cancer therapeutic response remain poorly understood. Trastuzumab is among the most commonly used drugs targeting the receptor tyrosine- protein kinase erbB-2 (ErbB2) in breast cancer, but its resistance is inevitable, severely ...
• APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats AI翻译
  作者：Brown, Rebecca E.; Coxon, Margo; Larsen, Benjamin; Allison, Maxwell; Chadha, Ariana; Mittelstadt, Isabelle; Mertz, Tony M.; Roberts, Steven A.; Freudenreich, Catherine H.
  作者单位：Tufts University; Washington State University; Washington State University; Tufts University; University of Vermont; University of Vermont
  摘要：CAG/CTG repeats are prone to expansion, causing several inherited human diseases. The initiating sources of DNA damage which lead to inaccurate repair of the repeat tract to cause expansions are not fully understood. Expansion- prone CAG/CTG repeats are actively transcribed and prone to forming stable R- loops with hairpin structures forming on the displaced single- stranded DNA (S- loops). We previously determined that damage by the Saccharomyces cerevisiae cytosine deaminase, Fcy1, was requi...
• The magnitude of legal wildlife trade and implications for species survival AI翻译
  作者：Marshall, Benjamin Michael; Alamshah, Aubrey L.; Cardoso, Pedro; Cassey, Phillip; Chekunov, Sebastian; Eskew, Evan A.; Fukushima, Caroline S.; Garcia-Diaz, Pablo; Gore, Meredith L.; Lockwood, Julie L.; Rhyne, Andrew L.; Sinclair, James S.; Strine, Colin Thomas; Stringham, Oliver C.; Tlusty, Michael F.; Valdez, Jose W.; Watters, Freyja; Hughes, Alice C.
  作者单位：University of Stirling; State University of New York (SUNY) System; Binghamton University, SUNY; Universidade de Lisboa; University of Helsinki; University of Adelaide; University of Idaho; University of Turku; University System of Maryland; University of Maryland College Park; Rutgers University System; Rutgers University New Brunswick; Roger Williams University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Rutgers University System; Rutgers University New Brunswick; University of Massachusetts System; University of Massachusetts Boston; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Martin Luther University Halle Wittenberg; University of Hong Kong
  摘要：The unsustainable use of wildlife is a primary driver of global biodiversity loss. No comprehensive global dataset exists on what species are in trade, their geographic origins, and trade's ultimate impacts, which limits our ability to sustainably manage trade. The United States is one of the world's largest importers of wildlife, with trade data compiled in the US Law Enforcement Management Information System (LEMIS). The LEMIS provides the most comprehensive publicly accessible wildlife trad...
• Fundamental constraints and questions from the study of martian meteorites and the need for returned samples AI翻译
  作者：Udry, Arya; Ostwald, Amanda M.; Day, James M. D.; Hallis, Lydia J.
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Smithsonian Institution; Smithsonian National Museum of Natural History; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Glasgow
  摘要：Physical materials from planetary bodies are crucial for understanding fundamental processes that constrain the evolution of the solar system, as samples can be analyzed at high precision and accuracy in Earth- based laboratories. Mars is the only planet outside of Earth from which we possess samples in the form of meteorites. Martian meteorites (n > 350) have enabled constraints to be placed on various aspects of the red planet's formation and evolution, notably: that Mars accreted and differ...
• The interaction of Serratia bacteria and harmonine in harlequin ladybird confers an interspecies competitive edge AI翻译
  作者：Zhang, Chaowei; Zhou, Hang; He, Kang; Xiao, Yiqi; Chen, Mengyao; Zuo, Zhangqi; Shu, Runguo; Geng, Yuhang; Jin, Shuo; Mei, Yang; He, Bingbing; Li, Fei
  作者单位：Zhejiang University; Guizhou University
  摘要：The harlequin ladybird, Harmonia axyridis, is a predatory beetle used globally to control pests such as aphids and scale insects. Originating from East Asia, this species has become highly invasive since its introduction in the late 19th century to Europe and North America, posing a threat to local biodiversity. Intraguild predation is hypothesized to drive the success of this invasive species, but the underlying mechanisms remain unknown. In this study, a feeding assay revealed that while har...
• Microbes could convert industrial wastewater into ecofriendly products From the dairy industry to tech, microbial helpers may offer a sustainable approach to handling waste AI翻译
  作者：Beans, Carolyn
• Monofluorinated acetal electrolyte for high- performance lithium metal batteries AI翻译
  作者：Zhang, Elizabeth; Chen, Yuelang; Holoubek, John; Yu, Zhiao; Zhang, Wenbo; Lyu, Hao; Choi, Il Rok; Kim, Sang Cheol; Serrao, Chad; Cui, Yi; Bao, Zhenan
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
  摘要：High degree of fluorination for ether electrolytes has resulted in improved cycling stability of lithium metal batteries due to stable solid electrolyte interphase (SEI) formation and good oxidative stability. However, the sluggish ion transport and environmental concerns of high fluorination degree drive the need to develop less fluorinated structures. Here, we depart from the traditional ether backbone and introduce bis(2- fluoroethoxy)methane (F2DEM), featuring monofluorination of the aceta...
• Completion of lunar magma ocean solidification at 4.43 Ga AI翻译
  作者：Dauphas, Nicolas; Zhang, Zhe J.; Chen, Xi; Barboni, Melanie; Szymanowski, Dawid; Schoene, Blair; Leya, Ingo; Mckeegan, Kevin D.
  作者单位：University of Chicago; Arizona State University; Arizona State University-Tempe; Swiss Federal Institutes of Technology Domain; ETH Zurich; Princeton University; University of Bern; University of California System; University of California Los Angeles
  摘要：Crystallization of the lunar magma ocean yielded a chemically unique liquid residuum named KREEP. This component is expressed as a large patch on the near side of the Moon and a possible smaller patch in the northwest portion of the Moon's South Pole-Aitken basin on the far side. Thermal models estimate that the crystallization of the lunar magma ocean (LMO) could have spanned from 10 and 200 My, while studies of radioactive decay systems have yielded inconsistent ages for the completion of LM...
• Characterizing progenitor cells in developing and injured spinal cord: Insights from single- nucleus transcriptomics and lineage tracing AI翻译
  作者：Zhang, Qi; Wu, Xianming; Fan, Yongheng; Zhang, Haipeng; Yin, Man; Xue, Xiaoyu; Yin, Yanyun; Jin, Chen; Quan, Rui; Jiang, Peipei; Liu, Yongguang; Yu, Cheng; Kuang, Wenhao; Chen, Bing; Li, Jiayin; Chen, Zhong; Hu, Yali; Xiao, Zhifeng; Zhao, Yannan; Dai, Jianwu
  作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Southern Medical University - China; Nanjing University; Southern Medical University - China; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of BioMedical Engineering - CAMS; Peking Union Medical College
  摘要：Various mature tissue- resident cells exhibit progenitor characteristics following injury. However, the existence of endogenous stem cells with multiple lineage potentials in the adult spinal cord remains a compelling area of research. In this study, we present a cross- species investigation that extends from development to injury. We used single- nucleus transcriptomic sequencing and genetic lineage tracing to characterize neural cells in the spinal cord. Our findings show that ciliated epend...