2期

最新文章

• Nonapoptotic role of EGL-1 in exopher production and neuronal health in Caenorhabditis elegans AI翻译
  作者：Wu, Zheng; Cardona, Eric A.; Cohn, Jesse A.; Pierce, Jonathan T.
  作者单位：University of Texas System; University of Texas Austin
  摘要：While traditionally studied for their proapoptotic functions in activating the caspase, research suggests BH3-only proteins also have other roles such as mitochondrial dynamics regulation. Here, we find that EGL-1, the BH3-only protein in Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria. EGL-1 facilitates exopher production p...
• Evolutionary adaptation under climate change: Aedes sp. demonstrates potential to adapt to warming AI翻译
  作者：Couper, Lisa I.; Dodge, Tristram O.; Hemker, James A.; Kim, Bernard Y.; Alonso, Moi Exposito-; Brem, Rachel B.; Mordecai, Erin A.; Bitter, Mark C.
  作者单位：Stanford University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley
  摘要：Climate warming is expected to shift the distributions of mosquitoes and mosquito- borne diseases, promoting expansions at cool range edges and contractions at warm range edges. However, whether mosquito populations could maintain their warm edges through evolutionary adaptation remains unknown. Here, we investigate the potential for thermal adaptation in Aedes sierrensis, a congener of the major disease vector species that experiences large thermal gradients in its native range, by assaying t...
• Partial PdAu nanoparticle embedding into TiO2 support accentuates catalytic contributions from the Au/TiO2 interface AI翻译
  作者：Lim, Kang Rui Garrick; Kaiser, Selina K.; Herring, Connor J.; Kim, Taek - Seung; Perich, Marta Perxes; Garg, Sadhya; O'Connor, Christopher R.; Aizenberg, Michael; van der Hoeven, Jessi E. S.; Reece, Christian; Montemore, Matthew M.; Aizenberg, Joanna
  作者单位：Harvard University; Harvard University; Tulane University; Harvard University; Utrecht University
  摘要：Despite the broad catalytic relevance of metal-support interfaces, controlling their chemical nature, the interfacial contact perimeter (exposed to reactants), and consequently, their contributions to overall catalytic reactivity, remains challenging, as the nanoparticle and support characteristics are interdependent when catalysts are prepared by impregnation. Here, we decoupled both characteristics by using a raspberry- colloid- templating strategy that yields partially embedded PdAu nanopar...
• Evolution of the iodine cycle and the late stabilization of the Earth's ozone layer AI翻译
  作者：Liu, Jingjun; Hardisty, Dalton S.; Kasting, James F.; Fakhraee, Mojtaba; Planavsky, Noah J.
  作者单位：Yale University; Michigan State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：The origin of complex life and the evolution of terrestrial ecosystems are fundamental aspects of the natural history on Earth. Here, we present evidence for a protracted stabilization of the Earth's ozone layer. The destruction of atmospheric ozone today is inherently linked to the cycling of marine and atmospheric iodine. Supported by multiple independent lines of geological evidence and examined through an iodine mass balance model, we find that elevated marine iodide content prevailed thro...
• Not so binary or generalizable: Brain sex differences with artificial neural networks AI翻译
  作者：Lockhart, Jeffrey W.; Fuentes, Agustin; Rippon, Gina; Eliot, Lise
  作者单位：University of Chicago; Princeton University; Aston University; Rosalind Franklin University of Medicine & Science; Chicago Medical School
• What we can learn about Mars from the magnetism of returned samples AI翻译
  作者：Weiss, Benjamin P.; Mansbach, Elias N.; Maurel, Clara; Sprain, Courtney J.; Hysell, Nicholas L. Swanson-; Williams, Wyn
  作者单位：Massachusetts Institute of Technology (MIT); Institut de Recherche pour le Developpement (IRD); INRAE; Aix-Marseille Universite; State University System of Florida; University of Florida; University of California System; University of California Berkeley; University of Edinburgh
  摘要：The Red Planet is a magnetic planet. The Martian crust contains strong magnetization from a core dynamo that likely was active during the Noachian period when the surface may have been habitable. The evolution of the dynamo may have played a central role in the evolution of the early atmosphere and the planet's transition to the current cold and dry state. However, the nature and history of the dynamo and crustal magnetization are poorly understood given the lack of well- preserved, oriented, ...
• The single- stranded DNA-binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells AI翻译
  作者：Dubois, Jean - Christophe; Bonnell, Erin; Filion, Amelie; Frion, Julie; Zimmer, Samuel; Khan, Muhammad Riaz; Teplitz, Gabriela M.; Casimir, Lisa; Methot, Elie; Marois, Isabelle; Idrissou, Mouhamed; Jacques, Pierre-Etienne; Wellinger, Raymund J.; Marechal, Alexandre
  作者单位：University of Sherbrooke; University of Sherbrooke; University of Sherbrooke
  摘要：To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms. In 10 to 15% of cancers, this is enabled by recombination- based alternative lengthening of telomeres pathways (ALT). ALT cells display several hallmarks including heterogeneous telomere length, extrachromosomal telomeric repeats, and ALT- associated PML bodies. ALT cells also have high telomeric replication stress (RS) enhanced by fork- stalling structures (R- loops and G4s) and altered chromatin s...
• Boreal forests are heading for an open state AI翻译
  作者：Rotbarth, Ronny; van Nes, Egbert H.; Scheffer, Marten; Holmgren, Milena
  作者单位：Wageningen University & Research
  摘要：The boreal forest biome is warming four times faster than the global average. Changes so far are moderate, but time lags in responses may transiently maintain forest states which are no longer supported by current environmental conditions. Here, we explore whether tree cover dynamics hint at the state to which the biome may be shifting. Our results suggest that global boreal tree cover is heading for a unimodal state of open forest (30 to 50%), contrasting starkly to the bimodal distribution o...
• The value of returning a sample of the Martian atmosphere AI翻译
  作者：Swindle, Timothy D.; Pack, Andreas; Schwenzer, Susanne P.; Young, Edward D.; Thiemens, Mark
  作者单位：University of Arizona; University of Gottingen; Open University - UK; University of California System; University of California Los Angeles
  摘要：The elemental and isotopic abundances of major species in the Martian atmosphere have been determined, but analyses often lack sufficient precision, and those of minor and trace species are frequently not well known. Many important questions about the evolution and current state of Mars require the kind of knowledge that can be gained from analysis of a returned sample of the Martian atmosphere. Key target species include the noble gases, nitrogen, and various species containing carbon, hydrog...
• Experimental coral reef communities transform yet persist under mitigated future ocean warming and acidification (vol 121, e2407112121, 2024) AI翻译
  作者：Jury, Christopher P.; Bahr, Keisha D.; Cros, Annick; Dobson, Kerri L.; Freel, Evan B.; Graham, Andrew T.; McLachlan, Rowan H.; Nelson, Craig E.; Price, James T.; de Souza, Mariana Rocha; Shizuru, Leah; Smith, Celia M.; Sparagon, Wesley J.; Squair, Cheryl A.; Timmers, Molly A.; Vicente, Jan; Webb, Maryann K.; Yamase, Nicole H.; Grottoli, Andrea G.; Toonen, Robert J.
  作者单位：University of Hawaii System; University of Hawaii Manoa; Texas A&M University System; Nature Conservancy; NERC National Oceanography Centre; University of Southampton; University System of Ohio; Ohio State University; Oregon State University; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; National Geographic Society