2期

最新文章

• Hidden domain boundary dynamics toward crystalline perfection AI翻译
  作者：Mangu, Anudeep; Stoica, Vladimir A.; Zheng, Hao; Yang, Tiannan; Zhang, Maohua; Wang, Huaiyu (Hugo); Zu, Rui; Nguyen, Quynh L.; Song, Sanghoon; Das, Sujit; Meisenheimer, Peter; Donoway, Elizabeth; Chollet, Matthieu; Sun, Yanwen; Turner, Joshua J.; Freeland, John W.; Wen, Haidan; Martin, Lane W.; Chen, Long-Qing; Gopalan, Venkatraman; Zhu, Diling; Cao, Yue; Lindenberg, Aaron M.
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Indian Institute of Science (IISC) - Bangalore; University of California System; University of California Berkeley; Rice University; Rice University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
  摘要：A central paradigm of nonequilibrium physics concerns the dynamics of heterogeneity and disorder, impacting processes ranging from the behavior of glasses to the emergent functionality of active matter. Understanding these complex mesoscopic systems requires probing the microscopic trajectories associated with irreversible processes, the role of fluctuations and entropy growth, and the timescales on which nonequilibrium responses are ultimately maintained. Approaches that illuminate these proc...
• Transforming literature screening: The emerging role of large language models in systematic reviews AI翻译
  作者：Delgado-Chaves, Fernando M.; Jennings, Matthew J.; Atalaia, Antonio; Wolff, Justus; Horvath, Rita; Mamdouh, Zeinab M.; Baumbach, Jan; Baumbach, Linda
  作者单位：University of Hamburg; Columbia University; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; University of Cambridge; Maastricht University; Egyptian Knowledge Bank (EKB); Zagazig University; University of Southern Denmark; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Hamburg
  摘要：Systematic reviews (SR) synthesize evidence- based medical literature, but they involve labor- intensive manual article screening. Large language models (LLMs) can select relevant literature, but their quality and efficacy are still being determined compared to humans. We evaluated the overlap between title- and abstract- based selected articles of 18 different LLMs and human- selected articles for three SR. In the three SRs, 185/4,662, 122/1,741, and 45/66 articles have been selected and cons...
• Synthesis of ethane from CO2 by a methyl transferase-inspired molecular catalyst AI翻译
  作者：Patra, Suman; Dinda, Souvik; Ghosh, Soumili; Roy, Triparna; Dey, Abhishek
  作者单位：Department of Science & Technology (India); Indian Association for the Cultivation of Science (IACS) - Jadavpur
  摘要：Molecular catalysts with a single metal center are reported to reduce CO2 to a wide range of valuable single-carbon products like CO, HCOOH, CH3OH, etc. However, these catalysts cannot reduce CO2 to two carbon products like ethane or ethylene and the ability to form C-C from CO2 remains mostly limited to heterogeneous material-based catalysts. We report a set of simple iron porphyrins with pendant thiol group can catalyze the reduction of CO2 to ethane (C2H6) with H2O as the proton source with...
• Profile of Bruce E. Tabashnik AI翻译
  作者：Ravindran, Sandeep
• Strong, ductile, and hierarchical hetero- lamellar- structured alloys through microstructural inheritance and refinement AI翻译
  作者：Shi, Peijian; Li, Yi; Li, Zhi; Jiang, Xin; Yan, Jie; Zhou, Rui; Qin, Yi; Lin, Yifan; Huang, Jingran; Tan, Bodong; Wang, Yinan; Wen, Tongqi; Ye, Beilin; Ling, Chunyan; Luan, Junhua; Shen, Zhe; Ding, Biao; Li, Qiang; Zheng, Tianxiang; Ren, Weili; Zhang, Tianlong; Ren, Yang; Zhong, Yunbo; Liu, C. T.; Gao, Huajian; Zhu, Yuntian
  作者单位：Shanghai University; City University of Hong Kong; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of High Performance Computing (IHPC); Peking University; University of Hong Kong; City University of Hong Kong; Hong Kong University of Science & Technology; City University of Hong Kong; Tsinghua University
  摘要：The strength-ductility trade- off exists ubiquitously, especially in brittle intermetallic- containing multiple principal element alloys (MPEAs), where the intermetallic phases often induce premature failure leading to severe ductility reduction. Hierarchical erogeneities represent a promising microstructural solution to achieve simultaneous strength-ductility enhancement. However, it remains fundamentally challenging to hierarchical heterostructures using conventional methods, which often rel...
• Modeling DNA methyltransferase function to predict epigenetic correlation patterns in healthy and cancer cells AI翻译
  作者：Tse, Ariana Y.; Spakowitz, Andrew J.
  作者单位：Stanford University; Stanford University
  摘要：DNA methylation is a crucial epigenetic modification that orchestrates chromatin remodelers that suppress transcription, and aberrations in DNA methylation result in a variety of conditions such as cancers and developmental disorders. While it is understood that methylation occurs at CpG-rich DNA regions, it is less understood how distinct methylation profiles are established within various cell types. In this work, we develop a molecular-transport model that depicts the genomic exploration of...
• Reconciling Archean organic- rich mudrocks with low primary productivity before the Great Oxygenation Event AI翻译
  作者：Lotem, Noam; Rasmussen, Birger; Zi, Jian -Wei; Zeichner, Sarah S.; Present, Theodore M.; On, Yinon M. Bar-; Fischer, Woodward W.
  作者单位：California Institute of Technology; University of Western Australia; Curtin University
  摘要：The organic carbon content of ancient rocks provides a fundamental record of the biosphere on early Earth. For over 50 y, the high organic content of Archean (>2.5 Ga) mudrocks has puzzled geologists and evolutionary biologists, because high biological primary productivity was unexpected for the nascent biosphere before the rise of O-2. Here, we took a different approach to resolve this apparent paradox, by studying the accumulation rates of Archean organic-rich mudrocks. We evaluated the sedi...
• Perspectives on Mars Sample Return: A critical resource for planetary science and exploration AI翻译
  作者：McSween, Harry Y., Jr.; Hamilton, Victoria E.; Farley, Kenneth A.
  作者单位：University of Tennessee System; University of Tennessee Knoxville; Southwest Research Institute; California Institute of Technology
  摘要：mission priority in the last two Planetary Decadal Surveys Medicine (hereafter, the National Academies) and was the highest priority flagship for Mars in the Decadal Survey that preceded them. This inspirational and challenging campaign, like the Apollo program's returned lunar samples, will potentially revolutionize our understanding of Mars and help inform how other planets are explored. MSR's technological advances will keep the NASA and European Space Agency at the forefront of planetary e...
• Reply to Kaestner et al.: Activation of PIEZO1 is not significant for the passage of red blood cells through biomimetic splenic slits AI翻译
  作者：Moreau, Alexis; Yaya, Francois; Lu, Huijie; Surendranath, Anagha; Charrier, Anne; Dehapiot, Benoit; Helfer, Emmanuele; Viallat, Annie; Peng, Zhangli
  作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS)
• CryoEM structure of an MHC- I/TAPBPR peptide- bound intermediate reveals the mechanism of antigen proofreading AI翻译
  作者：Sun, Yi; Pumroy, Ruth A.; Mallik, Leena; Chaudhuri, Apala; Wang, Chloe; Hwang, Daniel; Danon, Julia N.; Goli, Kimia Dasteh; Moiseenkova-Bell, Vera Y.; Sgourakis, Nikolaos G.
  作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania
  摘要：Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and TAPBPR promote the selection of immunogenic antigens from a large pool of intracellular peptides. Interactions of chaperoned MHC-I molecules with incoming peptides are transient in nature, and as a result, the precise antigen proofreading mechanism remains elusive. Here, we leverage a high- fidelity TAPBPR variant and con...