2期

最新文章

• PKM2 controls cochlear development through lactate- dependent transcriptional regulation AI翻译
  作者：Wu, Mingxuan; Jia, Gaogan; Liu, Yaoqian; Lou, Yiyun; Li, Yunjie; Xia, Mingyu; Li, Huawei; Li, Wenyan
  作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University
  摘要：Understanding the role of metabolic processes during inner ear development is essential for identifying targets for hair cell (HC) regeneration, as metabolic choices play a crucial role in cell proliferation and differentiation. Among the metabolic processes, growing evidence shows that glucose metabolism is closely related to organ development. However, the role of glucose metabolism in mammalian inner ear development and HC regeneration remains unclear. In this study, we found that glycolyti...
• Funding rules that promote equity in climate adaptation outcomes AI翻译
  作者：Pollack, Adam B.; Aguilar, Sara Santamaria -; Maduwantha, Pravin; Helgeson, Casey; Wahl, Thomas; Keller, Klaus
  作者单位：Dartmouth College; State University System of Florida; University of Central Florida; State University System of Florida; University of Central Florida; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Many climate policies adopt improving equity as a key objective. A key challenge is that policies often conceive of equity in terms of individuals but introduce strategies that focus on spatially coarse administrative areas. For example, the Justice40 Initiative in the United States requires 518 diverse federal programs to prioritize funds for disadvantaged census tracts. This strategy is largely untested and contrasts with the federal government's definition of equity as the consistent and sy...
• Superconducting critical temperature elevated by intense magnetic fields AI翻译
  作者：Wu, Z.; Chen, H.; Weinberger, T. I.; Cabala, A.; Graf, D. E.; Skourski, Y.; Xie, W.; Ling, Y.; Zhu, Z.; Sechovsky, V.; Valiska, M.; Grosche, F. M.; Eaton, A. G.
  作者单位：University of Cambridge; Charles University Prague; State University System of Florida; Florida State University; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Huazhong University of Science & Technology
  摘要：Below a critical temperature T-c, superconductors transport electrical charge without dissipative energy losses. The application of a magnetic field B generally acts to suppress Tc, up to some critical field strength at which T-c -> 0 K. Here, we investigate magnetic field-induced superconductivity in high-quality specimens of the triplet superconductor candidate UTe2 in pulsed magnetic fields up to B = 70 T. Strikingly, we find that this material has a higher T-c when B > 40 T (T-c approximat...
• Constraining the history of water and climate on Mars through light element stable isotope analysis of volatiles in returned martian samples AI翻译
  作者：Grady, Monica M.
  作者单位：Open University - UK
  摘要：Much has been learned about Mars through data returned from space missions and analyses of martian meteorites. There are, however, many questions still outstanding which cannot currently be answered-including the issue of whether there is, or was, life on Mars. The return of a cache of samples-including of the atmosphere-from separate locations in Jezero Crater and with differing petrogeneses will provide the international community with the opportunity to explore part of the evolutionary hist...
• The cGAS-STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM- deficient murine lung fibroblasts AI翻译
  作者：Haj, Majd; Frey, Yann; Levon, Amit; Maliah, Avishai; Ben-Yishay, Tal; Slutsky, Rachel; Smoom, Riham; Tzfati, Yehuda; Ben-David, Uri; Levy, Carmit; Elkon, Ran; Ziv, Yael; Shiloh, Yosef
  作者单位：Tel Aviv University; Hebrew University of Jerusalem
  摘要：Ataxia-telangiectasia (A- T) is a pleiotropic genome instability syndrome resulting from the loss of the homeostatic protein kinase ATM. The complex phenotype of A- T includes progressive cerebellar degeneration, immunodeficiency, gonadal atrophy, interstitial lung disease, cancer predisposition, endocrine abnormalities, chromosomal instability, radiosensitivity, and segmental premature aging. Cultured skin fibroblasts from A- T patients exhibit premature senescence, highlighting the associati...
• Targeted degradation of Pin1 by protein- destabilizing compounds (vol 121, e2403330121, 2024) AI翻译
  作者：Alboreggia, Giulia; Udompholkul, Parima; Rodriguez, Isaac; Blaha, Gregor; Pellecchia, Maurizio
• Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis AI翻译
  作者：Ito, Masaru; Yun, Yan; Kulkarni, Dhananjaya S.; Lee, Sunkyung; Sandhu, Sumit; Nunez, Briana; Hu, Linya; Lee, Kevin; Lim, Nelly; Hirota, Rachel M.; Prendergast, Rowan; Huang, Cynthia; Huang, Ivy; Hunter, Neil
  作者单位：Howard Hughes Medical Institute; University of California System; University of California Davis; University of California System; University of California Davis; University of Osaka; Brown University; University of California System; University of California Davis
  摘要：During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this crossover patterning results from nascent recombination sites competing to accrue a limiting pro- crossover RING- domain protein (COR) that diffuses between synapsed chromosomes. Here, we delineate the localization dynamics of three mammalian CORs in the mous...
• Teacher vaccinations enhance student achievement in Pakistan: The role of role models and theory of mind (vol 121, e2406034121, 2024) AI翻译
  作者：Mehmood, Sultan; Naseer, Shaheen; Chen, Daniel L.
• Beyond despair: Leveraging ecosystem restoration for resilience AI翻译
  作者：Smith, Carter S.; Demattia, Elizabeth A.; Albright, Elizabeth; Bromberger, Abigail F.; Hayward, Olivia G.; Mackinson, India J.; Mantell, Sydney A.; Mcadoo, Brian G.; Mcafee, Dominic; Mccollum, Aurora; Paxton, Avery B.; Roderer, Anne; Stevenson, Kathryn; Vidra, Rebecca L.; Zhao, Zixin
  作者单位：Duke University; University of Washington; University of Washington Seattle; Duke University; Duke University; University of Adelaide; National Oceanic Atmospheric Admin (NOAA) - USA; National Ocean Service, NOAA; National Centers for Coastal Ocean Science (NOOCS); National Oceanic Atmospheric Admin (NOAA) - USA; North Carolina State University
  摘要：Ecosystem restoration has historically been viewed as an ecological endeavor, but restoration possesses significant, yet largely untapped, potential as a catalyst for personal and social transformation. We highlight the opportunity for restoration to enhance community resilience by increasing agency and collective action and countering the pervasive perception that we are powerless witnesses to environmental decline. In this perspective, we take a bright spots approach and highlight successful...
• A conifer metabolite corrects episodic ataxia type 1 by voltage sensor- mediated ligand activation of Kv1.1 AI翻译
  作者：Manville, Rian W.; Foglia, Lorenzo; Yoshimura, Ryan F.; Hogenkamp, Derk J.; Nguyen, Amy; Yu, Alvin; Abbott, Geoffrey W.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Loss- of- function sequence variants in KCNA1, which encodes the voltage- gated potassium channel Kv1.1, cause Episodic Ataxia Type 1 (EA1) and epilepsy. Due to a paucity of drugs that directly rescue mutant Kv1.1 channel function, current therapeutic strategies for KCNA1- linked disorders involve indirect modulation of neuronal excitability. Native Americans have traditionally used conifer extracts to treat paralysis, weakness, and pain, all of which may involve altered electrical activity an...