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作者：Mok, Stephen; Liu, Huey; Cobanoglu, Didem Agac; Anang, Nana- Ama A. S.; Mancuso, James J.; Wherry, E. John; Allison, James P.
作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Pennsylvania; University of Texas System; UTMD Anderson Cancer Center
摘要：The effects of T cell differentiation arising from immune checkpoint inhibition targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA- 4) and programmed cell death protein 1 (PD- 1) on the immunological memory response remain unclear. Our investigation reveals that memory T cells generated by anti- CTLA- 4 exhibit greater expansion, cytokine preserves more T cell factor- 1 (TCF- 1)+ T cells during priming, while anti- PD- 1 leads to using conditional Tcf7- or Tox- knockout mice highlight...
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作者：Borg, Lars E.; Kruijer, Thomas S.
作者单位：United States Department of Energy (DOE); Lawrence Livermore National Laboratory
摘要：The radiogenic isotopic compositions of basaltic Martian meteorites (shergottites) and clinopyroxene/olivine cumulate meteorites (nakhlite/chassignites) are used to define the global evolution of Mars. However, the two main groups of meteorites demonstrate that their sources underwent divergent styles of magmatic evolution. The shergottites portray a planet that differentiated similar to 4.52 billion years ago via solidification of a magma ocean, producing incompatible element-depleted and -en...
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作者：Rachuri, Swaksha; Nepal, Binod; Shukla, Anurag; Ramanathan, Aarti; Morrisey, Joanne M.; Daly, Thomas; Mather, Michael W.; Bergman, Lawrence W.; Kortagere, Sandhya; Vaidya, Akhil B.
作者单位：Drexel University
摘要：Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target Plasmodium falciparum P-type ATPase (PfATP4). This essential protein is a Na+ pump responsible for the maintenance of Na+ homeostasis. PfATP4 belongs to the type two-dimensional (2D) subfamily of P-type ATPases, for which no structures have been determined. To gain better insight into the structure/function relationship of this validated drug target, we generated a homology model of PfATP4 based...
