2期

最新文章

• Targeted degradation of Pin1 by protein- destabilizing compounds (vol 121, e2403330121, 2024) AI翻译
  作者：Alboreggia, Giulia; Udompholkul, Parima; Rodriguez, Isaac; Blaha, Gregor; Pellecchia, Maurizio
• Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis AI翻译
  作者：Ito, Masaru; Yun, Yan; Kulkarni, Dhananjaya S.; Lee, Sunkyung; Sandhu, Sumit; Nunez, Briana; Hu, Linya; Lee, Kevin; Lim, Nelly; Hirota, Rachel M.; Prendergast, Rowan; Huang, Cynthia; Huang, Ivy; Hunter, Neil
  作者单位：Howard Hughes Medical Institute; University of California System; University of California Davis; University of California System; University of California Davis; University of Osaka; Brown University; University of California System; University of California Davis
  摘要：During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this crossover patterning results from nascent recombination sites competing to accrue a limiting pro- crossover RING- domain protein (COR) that diffuses between synapsed chromosomes. Here, we delineate the localization dynamics of three mammalian CORs in the mous...
• Teacher vaccinations enhance student achievement in Pakistan: The role of role models and theory of mind (vol 121, e2406034121, 2024) AI翻译
  作者：Mehmood, Sultan; Naseer, Shaheen; Chen, Daniel L.
• Beyond despair: Leveraging ecosystem restoration for resilience AI翻译
  作者：Smith, Carter S.; Demattia, Elizabeth A.; Albright, Elizabeth; Bromberger, Abigail F.; Hayward, Olivia G.; Mackinson, India J.; Mantell, Sydney A.; Mcadoo, Brian G.; Mcafee, Dominic; Mccollum, Aurora; Paxton, Avery B.; Roderer, Anne; Stevenson, Kathryn; Vidra, Rebecca L.; Zhao, Zixin
  作者单位：Duke University; University of Washington; University of Washington Seattle; Duke University; Duke University; Adelaide University; University of Adelaide; National Oceanic Atmospheric Admin (NOAA) - USA; National Ocean Service, NOAA; National Centers for Coastal Ocean Science (NOOCS); National Oceanic Atmospheric Admin (NOAA) - USA; North Carolina State University
  摘要：Ecosystem restoration has historically been viewed as an ecological endeavor, but restoration possesses significant, yet largely untapped, potential as a catalyst for personal and social transformation. We highlight the opportunity for restoration to enhance community resilience by increasing agency and collective action and countering the pervasive perception that we are powerless witnesses to environmental decline. In this perspective, we take a bright spots approach and highlight successful...
• The single- stranded DNA-binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells AI翻译
  作者：Dubois, Jean - Christophe; Bonnell, Erin; Filion, Amelie; Frion, Julie; Zimmer, Samuel; Khan, Muhammad Riaz; Teplitz, Gabriela M.; Casimir, Lisa; Methot, Elie; Marois, Isabelle; Idrissou, Mouhamed; Jacques, Pierre-Etienne; Wellinger, Raymund J.; Marechal, Alexandre
  作者单位：University of Sherbrooke; University of Sherbrooke; University of Sherbrooke
  摘要：To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms. In 10 to 15% of cancers, this is enabled by recombination- based alternative lengthening of telomeres pathways (ALT). ALT cells display several hallmarks including heterogeneous telomere length, extrachromosomal telomeric repeats, and ALT- associated PML bodies. ALT cells also have high telomeric replication stress (RS) enhanced by fork- stalling structures (R- loops and G4s) and altered chromatin s...
• Boreal forests are heading for an open state AI翻译
  作者：Rotbarth, Ronny; van Nes, Egbert H.; Scheffer, Marten; Holmgren, Milena
  作者单位：Wageningen University & Research
  摘要：The boreal forest biome is warming four times faster than the global average. Changes so far are moderate, but time lags in responses may transiently maintain forest states which are no longer supported by current environmental conditions. Here, we explore whether tree cover dynamics hint at the state to which the biome may be shifting. Our results suggest that global boreal tree cover is heading for a unimodal state of open forest (30 to 50%), contrasting starkly to the bimodal distribution o...
• The value of returning a sample of the Martian atmosphere AI翻译
  作者：Swindle, Timothy D.; Pack, Andreas; Schwenzer, Susanne P.; Young, Edward D.; Thiemens, Mark
  作者单位：University of Arizona; University of Gottingen; Open University - UK; University of California System; University of California Los Angeles
  摘要：The elemental and isotopic abundances of major species in the Martian atmosphere have been determined, but analyses often lack sufficient precision, and those of minor and trace species are frequently not well known. Many important questions about the evolution and current state of Mars require the kind of knowledge that can be gained from analysis of a returned sample of the Martian atmosphere. Key target species include the noble gases, nitrogen, and various species containing carbon, hydrog...
• Increasing pesticide diversity impairs soil microbial functions AI翻译
  作者：Ni, Bang; Xiao, Lu; Lin, Da; Zhang, Tian- Lun; Zhang, Qi; Liu, Yanjie; Chen, Quan; Zhu, Dong; Qian, Haifeng; Rillig, Matthias C.; Zhu, Yong- Guan
  作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shaoxing University; Kunming University of Science & Technology; Zhejiang University of Technology; Free University of Berlin; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Research Center for Eco-Environmental Sciences (RCEES), CAS
  摘要：Pesticide application is essential for stabilizing agricultural production. However, the effects of increasing pesticide diversity on soil microbial functions remain unclear, particularly under varying nitrogen (N) fertilizer management practices. In this study, we investigated the stochasticity of soil microbes and multitrophic networks through amplicon sequencing, assessed soil community functions related to carbon (C), N, phosphorus (P), and sulfur (S) cycling, and characterized the dominan...
• Funding rules that promote equity in climate adaptation outcomes AI翻译
  作者：Pollack, Adam B.; Aguilar, Sara Santamaria -; Maduwantha, Pravin; Helgeson, Casey; Wahl, Thomas; Keller, Klaus
  作者单位：Dartmouth College; State University System of Florida; University of Central Florida; State University System of Florida; University of Central Florida; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Many climate policies adopt improving equity as a key objective. A key challenge is that policies often conceive of equity in terms of individuals but introduce strategies that focus on spatially coarse administrative areas. For example, the Justice40 Initiative in the United States requires 518 diverse federal programs to prioritize funds for disadvantaged census tracts. This strategy is largely untested and contrasts with the federal government's definition of equity as the consistent and sy...
• Superconducting critical temperature elevated by intense magnetic fields AI翻译
  作者：Wu, Z.; Chen, H.; Weinberger, T. I.; Cabala, A.; Graf, D. E.; Skourski, Y.; Xie, W.; Ling, Y.; Zhu, Z.; Sechovsky, V.; Valiska, M.; Grosche, F. M.; Eaton, A. G.
  作者单位：University of Cambridge; Charles University Prague; State University System of Florida; Florida State University; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Huazhong University of Science & Technology
  摘要：Below a critical temperature T-c, superconductors transport electrical charge without dissipative energy losses. The application of a magnetic field B generally acts to suppress Tc, up to some critical field strength at which T-c -> 0 K. Here, we investigate magnetic field-induced superconductivity in high-quality specimens of the triplet superconductor candidate UTe2 in pulsed magnetic fields up to B = 70 T. Strikingly, we find that this material has a higher T-c when B > 40 T (T-c approximat...