7期

最新文章

• Turbulent mixing controls fixation of growing antagonisticpopulations AI翻译
  作者：Bauermann, Jonathan; Benzi, Roberto; Nelson, David R.; Shankar, Suraj; Toschi, Federico
  作者单位：Harvard University; North University of China; University of Rome Tor Vergata; University of Rome Tor Vergata; University of Michigan System; University of Michigan; Eindhoven University of Technology; Consiglio Nazionale delle Ricerche (CNR)
  摘要：Unlike coffee and cream that homogenize when stirred, growing micro-organisms(e.g., bacteria, baker's yeast) can actively kill each other and avoid mixing. How dosuch antagonistic interactions impact the growth and survival of competing strains,while being spatially advected by turbulent flows? By using numerical simulations of acontinuum model, we study the dynamics of two antagonistic strains that are dispersedby incompressible turbulent flows in two spatial dimensions. A key parameter is th...
• Interrogating nucleotide sequences with AI to understand codon usage patterns AI翻译
  作者：Elazar, Assaf; Mathew, Steve; Babu, M. Madan
  作者单位：St Jude Children's Research Hospital; Vellore Institute of Technology (VIT); VIT Vellore
• A deep learning-enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life AI翻译
  作者：Tang, Chenyu; Yi, Wentian; Xu, Muzi; Jin, Yuxuan; Zhang, Zibo; Chen, Xuhang; Liao, Caizhi; Kang, Mengtian; Gao, Shuo; Smielewski, Peter; Occhipinti, Luigi G.
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; Capital Medical University; Beihang University
  摘要：In wearable smart systems, continuous monitoring and accurate classification of dif-ferent sleep- related conditions are critical for enhancing sleep quality and preventing sleep- related chronic conditions. However, the requirements for device-skin coupling quality in electrophysiological sleep monitoring systems hinder the comfort and reli-ability of night wearing. Here, we report a washable, skin- compatible smart garment sleep monitoring system that captures local skin strain signals under...
• Mycorrhiza increases plant diversity and soil carbon storage in grasslands AI翻译
  作者：Zhang, Entao; Wang, Yang; Crowther, Thomas W.; Sun, Weicheng; Chen, Shiping; Zhou, Daowei; Shangguan, Zhouping; Huang, Jianhui; He, Jin - Sheng; Wang, Yanfen; Sheng, Jiandong; Tang, Lisong; Li, Xinrong; Dong, Ming; Wu, Yan; Hu, Shuijin; Bai, Yongfei; Yu, Guirui
  作者单位：Chinese Academy of Sciences; Institute of Botany, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Swiss Federal Institutes of Technology Domain; ETH Zurich; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Northwest A&F University - China; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Lanzhou University; Lanzhou University; Peking University; Xinjiang Agricultural University; Chinese Academy of Sciences; Xinjiang Institute of Ecology & Geography, CAS; Chinese Academy of Sciences; Hangzhou Normal University; Chinese Academy of Sciences; Chengdu Institute of Biology, CAS; North Carolina State University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS
  摘要：Experimental studies have shown that symbiotic relationships between arbuscular mycorrhizal (AM) fungi and host plants can regulate soil organic carbon (SOC) storage. Although the impacts of mycorrhiza are highly context- dependent, it remains unclear how these effects vary across broad spatial scales. Based on data from 2296 field sites across grassland ecosystems of China, here we show that mycorrhizal fungi symbiosis enhances SOC storage in the topsoil and subsoil through increasing plant d...
• Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling AI翻译
  作者：Avstrikova, Mariia; Rodriguez, Paula Milan; Burke, Sean M.; Hibbs, Ryan E.; Changeux, Jean-Pierre; Cecchini, Marco
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); University of Texas System; University of Texas Southwestern Medical Center; University of California System; University of California San Diego; Universite PSL; College de France; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
  摘要：The alpha 7 nicotinic acetylcholine receptor is a pentameric ligand- gated ion channel that plays an important role in neuronal signaling throughout the nervous system. Its implication in neurological disorders and inflammation has spurred the development of numerous compounds that enhance channel activation. However, the therapeutic potential of these compounds has been limited by the characteristically fast desensitization of the alpha 7 receptor. Using recent high- resolution structures fro...
• Deliberation during online bargaining reveals strategic information AI翻译
  作者：Cotet, Miruna; Zhao, Wenjia Joyce; Krajbich, Ian
  作者单位：University System of Ohio; Ohio State University; University of Warwick; University of California System; University of California Los Angeles; University System of Ohio; Ohio State University
  摘要：A standard assumption in game theory is that decision- makers have preplanned strategies telling them what actions to take for every contingency. In contrast, nonstrategic decisions often involve an on- the- spot comparison process, with longer response times (RT) for choices between more similarly appealing options. If strategic decisions also exhibit these patterns, then RT might betray private information and alter game theory predictions. Here, we examined bargaining behavior to determine ...
• CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk AI翻译
  作者：Nguyen, Lien; Ajredini, Ramadan; Guo, Shu; Romano, Lisa E. L.; Tomas, Rodrigo F.; Bell, Logan R.; Ranum, Paul T.; Zu, Tao; Coronel, Monica Banez; Kelley, Chase P.; Redding-Ochoa, Javier; Nizamis, Evangelos; Melloni, Alexandra; Connors, Theresa R.; Gaona, Angelica; Thangaraju, Kiruphagaran; Pletnikova, Olga; Clark, H. Brent; Davidson, Beverly L.; Yachnis, Anthony T.; Golde, Todd E.; Lou, Xiangyang; Wang, Eric T.; Renton, Alan E.; Goate, Alison; Valdmanis, Paul N.; Prokop, Stefan; Troncoso, Juan C.; Hyman, Bradley T.; Ranum, Laura P. W.
  作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Johns Hopkins University; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Minnesota System; University of Minnesota Twin Cities; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; State University System of Florida; University of Florida; State University System of Florida; University of Florida
  摘要：Alzheimer's disease (AD) affects more than 10% of the population >= 65 y of age, but the underlying biological risks of most AD cases are unclear. We show anti-poly-glycine-arginine (a-polyGR) positive aggregates frequently accumulate in sporadic AD autopsy brains (45/80 cases). We hypothesize that these aggregates are caused by one or more polyGR-encoding repeat expansion mutations. We developed a CRISPR/deactivated-Cas9 enrichment strategy to identify candidate GR-encoding repeat expansion m...
• Fast Interpretable Greedy-Tree Sums AI翻译
  作者：Tan, Yan Shuo; Singh, Chandan; Nasseri, Keyan; Agarwal, Abhineet; Duncan, James; Ronen, Omer; Epland, Matthew; Kornblith, Aaron; Yu, Bin
  作者单位：National University of Singapore; University of California System; University of California Berkeley; Microsoft; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Modern machine learning has achieved impressive prediction performance, but often sacrifices interpretability, a critical consideration in high-stakes domains such as medicine. In such settings, practitioners often use highly interpretable decision tree models, but these suffer from inductive bias against additive structure. To overcome this bias, we propose Fast Interpretable Greedy-Tree Sums (FIGS), which generalizes the Classification and Regression Trees (CART) algorithm to simultaneously ...
• Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter AI翻译
  作者：Khandelwal, Nitesh Kumar; Gupta, Meghna; Kumar, Paras; Balasubramani, Sree Ganesh; Echeverria, Ignacia; Stroud, Robert M.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Oregon Health & Science University
  摘要：Urate provides similar to 50% of the reducing potential in human and primate plasma which is key to detoxifying reactive oxygen by- products of cellular metabolism. Urate is the endpoint of purine metabolism in primates, and its concentration in plasma is a bal-ance between excretion from kidney and intestine, and subsequent reabsorption in and through cells of kidney proximal tubules to maintain a regulated concentration in plasma. SLC2A9 is the primary transporter that returns urate from the...
• The canonical RPA complex interacts with Est3 to regulate yeast telomerase activity AI翻译
  作者：Moeller-McCoy, Corinne A.; Wieser, Thomas A.; Lubin, Johnathan W.; Gillespie, Abigail E.; Ramirez, Jocelyn A.; Paschini, Margherita; Wuttke, Deborah S.; Lundblad, Victoria
  作者单位：Salk Institute; University of California System; University of California San Diego; University of Colorado System; University of Colorado Boulder; University of California System; University of California San Diego; University of Colorado System; University of Colorado Anschutz Medical Campus; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：In most eukaryotic organisms, cells that rely on continuous cell division employ the enzyme telomerase which replenishes chromosome termini through the addition of telomeric repeats. In budding yeast, the telomerase holoenzyme is composed of a catalytic core associated with two regulatory subunits, Est1 and Est3. The Est1 protein binds a telomere- specific RPA-like complex to recruit telomerase to chromosome ends. However, the regulatory function of the Est3 subunit has remained elusive. We re...