7期

最新文章

• A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression AI翻译
  作者：Li, Jiabo; Shih, Ling - Kai; Markwell, Steven M.; Olson, Cheryl L.; Sullivan, David P.; Arvanitis, Constadina; Ross, James L.; Lam, Nicolas G.; Nuszen, Hannah; Hambardzumyan, Dolores; Becher, Oren J.; Brat, Daniel J.
  作者单位：Ann & Robert H. Lurie Children's Hospital of Chicago; Robert H. Lurie Comprehensive Cancer Center; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Emory University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：All glioblastoma (GBM) molecular subsets share the common trait of accelerated progression following necrosis, which cannot be adequately explained by cellular proliferation arising from accumulated genetic alterations. Counter to dogma that cancer outgrows its blood supply, we suggest that development of necrosis is not merely a consequence of aggressive neoplastic growth but could be a contributing force causing tumor microenvironment (TME) restructuring and biologic progression. Mechanisms ...
• Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia AI翻译
  作者：Wang, Jun-Yu; Gui, Tuan-Tuan; Jiao, Bo; Liu, Xuan; Ma, Xiao-Lin; Wang, Cheng; Qiao, Jing; Liu, Wei-Yang; Peng, Li-Jun; Rena, Jia-Yi; Zhua, Yong-Mei; Weng, Xiang-Qin; Wang, Chao; Zhang, Qian-Qian; Song, Gao-Xian; Dai, Yu- Ting; Wang, Zhen-Yi; Lv, Gang; Gao, Chen-Xu; Qiao, Niu; Zhang, Ming; Tan, Yun; Liu, Yuan- Fang; Wang, Sheng-Yue; Hou, Jian; Jing, Duo- Hui; Lyu, An-Kang; Mi, Jian-Qing; Chen, Zhu; Chen, Wen-Lian; Yin, Tong; Fang, Hai; Wang, Jin; Chen, Sai-Juan
  作者单位：Shanghai Jiao Tong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Sciences; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai University of Traditional Chinese Medicine
  摘要：Acute lymphoblastic leukemia (ALL) poses challenges in adult patients, considering its heterogeneous nature and often suboptimal treatment outcomes. Here, we performed a study on 201 newly diagnosed adult ALL cases (age >= 15 y) to generate intracellular and dynamic serum metabolomic profiles. Our findings revealed a predominant increase in bile acid (BA) metabolites in serum, alongside metabolic rewiring that supported highly proliferative states and actively metabolic signaling, such as enri...
• Bacterial species with different nanocolony morphologies have distinct flow-dependent colonization behaviors AI翻译
  作者：Hallinen, Kelsey M.; Bodine, Steven P.; Stone, Howard A.; Muir, Tom W.; Wingreen, Ned S.; Gitai, Zemer
  作者单位：Princeton University; Princeton University; Princeton University; Princeton University; Princeton University
  摘要：Fluid flows are dominant features of many bacterial environments, and flow can often impact bacterial behaviors in unexpected ways. For example, the most common type of cardiovascular infection is heart valve colonization by gram- positive bacteria like Staphylococcus aureus and Enterococcus faecalis (endocarditis). This behavior is counter-intuitive because heart valves experience high shear rates that would naively be expected to reduce colonization. To determine whether these bacteria prefe...
• Variable-strength nonlocal measurements reveal quantum violations of classical counting principles AI翻译
  作者：Lupu-Gladstein, Noah; Pang, Ou Teen Arthur; Ferretti, Hugo; Tham, Weng-Kian; Steinberg, Aephraim M.; Bonsma-Fisher, Kent; Brodutch, Aharon
  作者单位：University of Toronto; University of Toronto; Canadian Institute for Advanced Research (CIFAR); National Research Council Canada
  摘要：We implement a variant of the quantum pigeonhole paradox thought experiment to study whether classical counting principles survive in the quantum domain. We observe strong measurements significantly violate the pigeonhole principle (that among three pigeons in two holes, at least one pair must be in the same hole) and the sum rule (that the number of pigeon pairs in the same hole is the sum of the number of pairs across each of the holes) in an ensemble that is pre- and postselected into parti...
• Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis AI翻译
  作者：Rad, Laila M.; Hughes, Kevin R.; Wheeler, Sydney N.; Decker, Joseph T.; Orbach, Sophia M.; Galvan, Angelica; Thornhill, Jasmine; Griffin, Kate, V; Turkistani, Hamza; Urie, Russell R.; Irani, David N.; Shea, Lonnie D.; Morris, Aaron H.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Primary progressive multiple sclerosis (MS) is a demyelinating autoimmune disease with only a single class of FDA- approved treatment, B cell depletion. Novel treatments could emerge from a deeper understanding of the interplay between multiple cell types within diseased tissue throughout progression. We initially describe an engineered biomaterial-based immunological niche (IN) as a surrogate for diseased tissue to investigate immune cell function and phenotype dynamics throughout a chronic p...
• JFK, a Kelch domain- containing F- box protein, links the SCF complex to p53 regulation (vol 106, pg 10195, 2009) AI翻译
  作者：Sun, Luyang; Shi, Lei; Li, Wenqian; Yu, Wenhua; Liang, Jing; Zhang, Hua; Yang, Xiaohan; Wang, Yan; Li, Ruifang; Yao, Xingrong; Yi, Xia; Shang, Yongfeng
• Substrate and climate determine terrestrial litter decomposition AI翻译
  作者：Wu, Qiuxia; Ni, Xiangyin; Sun, Xinyao; Chen, Zihao; Hong, Songbai; Berg, Bjoern; Zheng, Mianhai; Chen, Ji; Zhu, Jingjing; Ai, Ling; Zhang, Yichen; Wu, Fuzhong
  作者单位：Fujian Normal University; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Ministry of Natural Resources of the People's Republic of China; University of Helsinki; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; Institute of Earth Environment, CAS; Peking University
  摘要：Litter decomposition is a fundamental biogeochemical process for carbon flux and nutrient cycling in terrestrial ecosystems, yet the global variation in decomposition rates and their covariations with climate and substrate are not fully understood. Here, we synthesized a global dataset of 6,733 independent observations across six continents to illustrate the climatic and substrate controls over litter decomposi-tion. The average decomposition rates of various litter types ranged from 0.74 to 4...
• Ethylene response factor SlERF.D6 promotes ripening in part through transcription factors SlDEAR2 and SlTCP12 AI翻译
  作者：Chen, Yao; Wang, Xin; Colantonio, Vincent; Gao, Zhuo; Pei, Yangang; Fish, Tara; Ye, Jie; Courtney, Lance; Thannhauser, Theodore W.; Ye, Zhibiao; Liu, Yongsheng; Fei, Zhangjun; Liu, Mingchun; Giovannoni, James J.
  作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Sichuan University; Huazhong Agricultural University; Hubei Hongshan Laboratory; United States Department of Agriculture (USDA); Huazhong Agricultural University; Cornell University; Anhui Agricultural University
  摘要：Ripening is crucial for the development of fleshy fruits that release their seeds following consumption by frugivores and are important contributors to human health and nutritional security. Many genetic ripening regulators have been identified, especially in the model system tomato, yet more remain to be discovered and integrated into comprehensive regulatory models. Most tomato ripening genes have been studied in pericarp tissue, though recent evidence indicates that locule tissue is a site ...
• Wholesale flat subduction of the Indian slab and northward mantle convective flow: Plateau growth and driving force of the India-Asia collision AI翻译
  作者：Ma, Jincheng; Song, Xiaodong; Bunge, Hans-Peter; Fichtner, Andreas; Tian, You
  作者单位：Peking University; University of Munich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Jilin University
  摘要：The tectonic evolution of the Tibetan Plateau has been influenced by continental collision and postcollisional convergence of Indian and Eurasian plates, both of which have undoubtedly imposed their imprints on the lithosphere and upper-mantle structures beneath the collision zone. However, the mode by which the Indian Plate has subducted beneath Tibet, and its driving forces, have been highly uncertain. Here, we present seismic evidence from a full-waveform tomographic model that reveals flat...
• Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance AI翻译
  作者：Zhang, Boyao; Orning, Pontus; Lehman, Jesse W.; Dinis, Alexandre; Torres-Ulloa, Leslie; Elling, Roland; Kelliher, Michelle A.; Bertin, John; Proulx, Megan K.; Goguen, Jon D.; Ryan, Liv; Kandasamy, Richard K.; Espevik, Terje; Pai, Athma A.; Fitzgerald, Katherine A.; Lien, Egil
  作者单位：University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; Norwegian University of Science & Technology (NTNU); University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of Freiburg; University of Freiburg; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; GlaxoSmithKline; Glaxosmithkline USA; Sanofi-Aventis; Sanofi USA; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; Mayo Clinic; Norwegian University of Science & Technology (NTNU); University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School
  摘要：Multiple cell death and inflammatory signaling pathways converge on two critical factors: receptor- interacting serine/threonine kinase 1 (RIPK1) and caspase-8. Careful regulation of these molecules is critical to control apoptosis, pyroptosis, and inflammation. Here, we found a pivotal role of Raver1 as an essential regulator of Ripk1 pre-mRNA splicing, expression, and functionality and the subsequent caspase-8- dependent inflammatory cell death. We show that Raver1 influences mRNA diversity ...