7期

最新文章

• Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer's disease AI翻译
  作者：Yang, Xin; Wang, Ye; Qiao, Yi; Lin, Jingwen; Lau, Jackie K. Y.; Fu, Wing-Yu; Fu, Amy K. Y.; Ip, Nancy Y.
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
  摘要：Cell surface receptors, including erythropoietin- producing hepatocellular A4 (EphA4), are important in regulating hippocampal synapse loss, which is the key driver of memory decline in Alzheimer's disease (AD). However, the cell- specific roles and mechanisms of EphA4 are unclear. Here, we show that EphA4 expression is elevated in hippocampal CA1 astrocytes in AD conditions. Specific knockout of astrocytic EphA4 ameliorates excitatory synapse loss in the hippocampus in AD transgenic mouse mod...
• Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY 1/2 for binding to Spindlins AI翻译
  作者：Arlt, Martin F.; Kruger, Alyssa N.; Swanepoel, Callie M.; Mueller, Jacob L.
  作者单位：University of Michigan System; University of Michigan
  摘要：The house mouse X and Y chromosomes have recently acquired multicopy, rapidly evolving gene families representing an evolutionary arms race. This arms race between proteins encoded by X- linked Slxl1/Slx and Y- linked Sly gene families can distort offspring sex ratio, but how these proteins compete remains unknown. Here, we report how Slxl1/Slx and Sly encoded proteins compete in a protein family-specific and dose- dependent manner using yeast. Specifically, SLXL1 competes with SLY1 and SLY2 f...
• A method for unsupervised learning of coherent spatiotemporal patterns in multiscale data AI翻译
  作者：Lapo, Karl; Ichinaga, Sara M.; Kutz, J. Nathan
  作者单位：University of Innsbruck; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：The unsupervised and principled diagnosis of multiscale data is a fundamental obstacle in modern scientific problems from, for instance, weather and climate prediction, neurology, epidemiology, and turbulence. Multiscale data are characterized by a combination of processes acting along multiple dimensions simultaneously, spatiotemporal scales across orders of magnitude, nonstationarity, and/or invariances such as translation and rotation. Existing methods are not well-suited to multiscale data...
• AI protocol for retrieving protein dynamic structures from two- dimensional infrared spectra AI翻译
  作者：Ye, Sheng; Zhu, Lvshuai; Zhao, Zhicheng; Wu, Fan; Li, Zhipeng; Wang, Binbin; Zhong, Kai; Sun, Changyin; Mukamel, Shaul; Jiang, Jun
  作者单位：Anhui University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University of Groningen; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Understanding the dynamic evolution of protein structures is crucial for uncovering their biological functions. Yet, real- time prediction of these dynamic structures remains a significant challenge. Two- dimensional infrared (2DIR) spectroscopy is a powerful tool for analyzing protein dynamics. However, translating its complex, low- dimensional signals into detailed three- dimensional structures is a daunting task. In this study, we introduce a machine learning- based approach that accurately...
• Ratio- based indicators for cytosolic Ca2+with visible light excitation AI翻译
  作者：Zhou, Xinqi; Belavek, Kayla J.; Navarro, Marisol X.; Martinez, Kayli N.; Hinojosa, Abigail; Miller, Evan W.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Calcium ions (Ca2+) play central roles in cellular physiology. Fluorescent indicators for Ca2+ ions revolutionized our ability to make rapid, accurate, and highly parallel measurement of Ca2+ concentrations in living cells. The use of ratio- based imaging with one particular indicator, fura- 2, allowed practitioners to correct for a number of experimental confounds, including dye bleaching, variations in sample thickness, and fluctuations in illumination intensity. Ratio- based imaging with fu...
• Unequal resource division occurs in the absence of group division and identity AI翻译
  作者：Deschrijver, Eliane; Ramsey, Richard
  作者单位：University of Sydney; Macquarie University; Ghent University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Based on the seminal minimal group experiment, the widely influential social identity theory has, in the last 45 y, led to the belief that discrimination follows from intergroup relations and social identity. A large body of research evidenced that people discriminate against members of their out versus ingroup, even if groups and identities were assigned on the basis of a quantity estimate, aesthetic judgment, or a chance outcome. But to what extent may unequal resource division be accounted ...
• Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses AI翻译
  作者：Neuman, Benjamin W.; Smart, Alexandria; Gilmer, Orian; Smyth, Redmond P.; Vaas, Josef; Boeker, Nicolai; Samborskiy, Dmitry, V; Bartenschlager, Ralf; Seitz, Stefan; Gorbalenya, Alexander E.; Caliskan, Neva; Lauber, Chris
  作者单位：Texas A&M University System; Texas A&M University College Station; Helmholtz Association; Helmholtz-Center for Infection Research; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Helmholtz Association; Helmholtz-Center for Infection Research; Lomonosov Moscow State University; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of Regensburg
  摘要：Positive- strand RNA viruses of the order Nidovirales have the largest known RNA genomes of vertebrate and invertebrate viruses with 36.7 and 41.1 kb, respectively. The acquisition of a proofreading exoribonuclease (ExoN) by an ancestral nidovirus enabled crossing of the 20 kb barrier. Other factors constraining genome size variations in nidoviruses remain poorly defined. We assemble 76 genome sequences of invertebrate nidoviruses from >500.000 published transcriptome experiments and triple th...
• Mapping of the full polarization switching pathways for HfO2 and its implications AI翻译
  作者：Hu, Qi; Lv, Shuning; Tsai, Hsiaoyi; Xue, Yufeng; Jing, Xixiang; Lin, Fanrong; Tong, Chuanjia; Cao, Tengfei; Teobaldi, Gilberto; Liu, Li - Min
  作者单位：Beihang University; Beihang University; Northwestern Polytechnical University; Nanjing University of Aeronautics & Astronautics; Nanjing University of Aeronautics & Astronautics; Central South University; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory
  摘要：The discovery of ferroelectric phases in HfO2 offers insights into ferroelectricity. Its unique fluorite structure and complex polarization switching pathways exhibit distinct characteristics, challenging conventional analysis methods. Combining group theory and first- principles calculations, we identify numerous unconventional electric polarization switching pathways in HfO2 with energy barriers of 0.32 to 0.57 eV as a function of the different shift in the suboxygen lattices. In total, we i...
• To enhance sustainable development goal research, open up commercial satellite image archives AI翻译
  作者：Rufin, Philippe; Meyfroidt, Patrick; Akinyemi, Felicia O.; Estes, Lyndon; Ibrahim, Esther Shupel; Jain, Meha; Kerner, Hannah; Lisboa, Sa Nogueira; Lobell, David; Nakalembe, Catherine; Persello, Claudio; Picoli, Michelle C. A.; Ribeiro, Natasha; Sitoe, Almeida Alberto; Waha, Katharina; Wang, Sherrie
  作者单位：Universite Catholique Louvain; Humboldt University of Berlin; Fonds de la Recherche Scientifique - FNRS; Karlstad University; University of Bern; Clark University; Leibniz Association; Leibniz Zentrum fur Agrarlandschaftsforschung (ZALF); University of Michigan System; University of Michigan; Arizona State University; Arizona State University-Tempe; Eduardo Mondlane University; Stanford University; Stanford University; University System of Maryland; University of Maryland College Park; University of Twente; Food & Agriculture Organization of the United Nations (FAO); University of Augsburg; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
• Osteocyte connexin hemichannels and prostaglandin E2 release dictate bone marrow mesenchymal stromal cell commitment AI翻译
  作者：Zhang, Jingruo; Acosta, Francisca M.; Wang, Xuewei; Zhao, Dezhi; Zhang, Lidan; Hua, Rui; Guo, Qianjin; Zhong, Leilei; Qin, Ling; Riquelme, Manuel A.; Jiang, Jean X.
  作者单位：University of Texas System; University of Texas at San Antonio; University of Pennsylvania
  摘要：Bone is a dynamic organ constantly undergoing remodeling with both bone formation and resorption. Bone formation is mediated by osteoblasts originating from the differentiation of bone marrow (BM) mesenchymal stem and progenitor cells (BM- MSPCs). However, how bone cells communicate with BM-MSPCs to coordinate bone formation remains largely elusive. Here, we unveil a key role of osteocyte connexin 43 (Cx43) hemichannels in regulating the lineage commitment of BM- MSPCs. Two transgenic mouse mo...