7期

最新文章

• Photostationary state assumption seriously underestimates NOx emissions near large point sources at 10 to 60 m pixel resolution AI翻译
  作者：Chen, Lang; Song, Zhe; Yao, Ningning; Xi, Huan; Li, Jian; Gao, Peng; Chen, Yulei; Su, Haoyuan; Sun, Yuhai; Jiang, Boqiong; Chen, Jianmin; Zhang, Yuanhang; Zhu, Tong; Li, Pengfei; Pang, Xiaobing; Yu, Shaocai
  作者单位：Zhejiang Gongshang University; Zhejiang Gongshang University; Zhejiang University; Fudan University; Peking University; Chinese Academy of Sciences; Shanghai Institute of Technical Physics, CAS; Zhejiang University of Technology
• Detrimental influence of Arginase-1 in infiltrating macrophages on poststroke functional recovery and inflammatory milieu AI翻译
  作者：Kim, Hyung Soon; Jee, Seung Ah; Einisadr, Ariandokht; Seo, Yeojin; Seo, Hyo Gyeong; Jang, Byeong Seong; Park, Hee Hwan; Chung, Won-Suk; Kim, Byung Gon
  作者单位：Ajou University; Ajou University; Korea Advanced Institute of Science & Technology (KAIST); Institute for Basic Science - Korea (IBS); Ajou University
  摘要：Poststroke inflammation critically influences functional outcomes following ischemic stroke. Arginase- 1 (Arg1) is considered a marker for anti- inflammatory macrophages, associated with the resolution of inflammation and promotion of tissue repair in various pathological conditions. However, its specific role in poststroke recovery remains to be elucidated. This study investigates the functional impact of Arg1 expressed in macrophages on poststroke recovery and inflammatory milieu. We observe...
• Machine learning-enhanced surface- enhanced spectroscopic detection of polycyclic aromatic hydrocarbons in the human placenta AI翻译
  作者：Neumann, Oara; Ju, Yilong; Alvarado, Andres B. Sanchez -; Zhou, Guodong; Jiang, Weiwu; Moorthy, Bhagavatula; Suter, Melissa A.; Patel, Ankit; Nordlander, Peter; Halas, Naomi J.
  作者单位：Rice University; Rice University; Rice University; Rice University; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Rice University
  摘要：The detection and identification of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, polycyclic aromatic compounds (PACs), are essential for environmental and health monitoring, for assessing toxicological exposure and their associated health risks. PAHs/PACs are the most dangerous chemicals found in tobacco smoke, and cigarette use during pregnancy can convey these molecules to the developing fetus through the placenta. This exposure is associated with many negative health outco...
• Allosteric genetically encoded biosensor for spatiotemporal monitoring of endogenous RNA dynamics in living cells AI翻译
  作者：Yuan, Deyu; He, Huan; Song, William; Ma, Duhan; Xie, Mingfeng; Wang, Yuchun; Wei, Jinliang; Wei, Jinliang; He, Qianyu; Bao, Yongli; Zhao, Yongyun
  作者单位：Northeast Normal University - China; Sichuan University
  摘要：Functions of RNAs are associated with their abundance and unique subcellular localizations. RNA imaging methods for spatiotemporal monitoring of RNA dynamics would facilitate the discovery of unknown functions of RNA, yet improving RNA imaging is challenging because of limitations in methods for directly monitoring native RNA, especially the dynamics of RNA transport and concentration fluctuation. Herein, a label- free and conformation switching-based genetically encoded sensor, termed the Dua...
• Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection AI翻译
  作者：Cremin, Michael; Ramirez, Valerie T.; Sanchez, Kristina; Tay, Emmy; Murray, Kaitlin; Brust-Mascher, Ingrid; Reardon, Colin
  作者单位：University of California System; University of California Davis
  摘要：Immune responses in the intestine are intricately balanced to prevent pathogen entry without inducing immunopathology. The nervous system is well established to interface with the immune system to fine- tune immunity in various organ systems including the gastrointestinal tract. Specialized sensory neurons can detect bacteria, bacterial products, and the resulting inflammation, to coordinate the immune response in the gastrointestinal tract. These sensory neurons release peptide neurotransmitt...
• Identification of a protective antigen reveals the trade- off between iron acquisition and antigen exposure in a global fungal pathogen AI翻译
  作者：Li, Yeqi; Pham, Tuyetnhu; Hipsher, Kenton; Lee, Christopher W. J.; Jiao, Jie; Penninger, Josef M.; Kronstad, James W.; Fan, Yumeng; Zhao, Youbao; Ambati, Suresh; Meagher, Richard B.; Xie, Xiaofeng; Lin, Xiaorong
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of British Columbia; University of British Columbia; Medical University of Vienna; Helmholtz Association; Helmholtz-Center for Infection Research; Austrian Academy of Sciences; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); University System of Georgia; University of Georgia
  摘要：Systemic infections caused by Cryptococcus claim over 161,000 lives annually, with global mortality rate close to 70% despite antifungal therapies. Currently, no vaccine is available. To develop an effective multivalent vaccine against this free- living oppor-tunistic eukaryotic pathogen, it is critical to identify protective antigens. We previously discovered ZNF2oe strains elicit protective host immune responses and increase the abundance of antigens present in the capsule, which is required...
• Photoreceptor- induced LHL4 protects the photosystem II monomer in Chlamydomonas reinhardtii AI翻译
  作者：Dannay, Marie; Bertin, Chloe; Cavallari, Eva; Albanese, Pascal; Tolleter, Dimitri; Giustini, Cecile; Menneteau, Mathilde; Brugiere, Sabine; Coute, Yohann; Finazzi, Giovanni; Demarsy, Emilie; Ulm, Roman; Allorent, Guillaume
  作者单位：Centre National de la Recherche Scientifique (CNRS); CEA; INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University of Geneva; CEA; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University of Geneva; Universite Paris Saclay; UNICANCER; Gustave Roussy; Centre National de la Recherche Scientifique (CNRS)
  摘要：Photosynthesis, the fundamental process using light energy to convert carbon dioxide to organic matter, is vital for life on Earth. It relies on capturing light through light- harvesting complexes (LHC) in photosystem I (PSI) and PSII and on the conver-sion of light energy into chemical energy. Composition and organization of PSI and PSII core complexes are well conserved across evolution. PSII is particularly sensitive to pho-todamage but benefits from a large diversity of photoprotective mec...
• Clinical evaluation of patterned dried plasma spot cards to support quantification of HIV viral load and reflexive genotyping AI翻译
  作者：Morbioli, Giorgio Gianini; Baillargeon, Keith R.; Kalimashe, Monalisa N.; Kana, Vibha; Zwane, Hloniphile; van der Walt, Cheri; Tierney, Allison J.; Mora, Andrea C.; Goosen, Mark; Jagaroo, Rivashni; Brooks, Jessica C.; Hunt, Gillian; Jordan, Michael R.; Tang, Alice; Mace, Charles R.
  作者单位：Tufts University; National Institute for Communicable Diseases (NICD); Tufts University; Massachusetts Department of Public Health; Tufts University
  摘要：Quantifying viral load, a key indicator required to achieve control and elimination of the HIV epidemic, requires cell- free plasma or serum to ensure measurements are not biased by proviral DNA contained in infected CD4 T lymphocytes. Plasma separation cards (PSC) collect and preserve a dried specimen, which makes them practical solutions for decentralized sample collection and transport in limited- resource settings. However, physiological variations in hematocrit levels can introduce signif...
• Spatial profiling of the interplay between cell type- and vision- dependent transcriptomic programs in the visual cortex AI翻译
  作者：Xie, Fangming; Jain, Saumya; Xu, Runzhe; Butrus, Salwan; Tan, Zhiqun; Xu, Xiangmin; Shekhar, Karthik; Zipursky, S. Lawrence
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University System of Georgia; Georgia Institute of Technology; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Irvine; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：How early sensory experience during critical periods of postnatal life affects the organization of the mammalian neocortex at the resolution of neuronal cell types is poorly understood. We previously reported that the functional and molecular profiles of layer 2/3 (L2/3) cell types in the primary visual cortex (V1) are vision- dependent [S. Cheng et al., Cell 185, 311-327.e24 (2022)]. Here, we characterize the spatial organization of L2/3 cell types with and without visual experience. Spatial ...
• Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos AI翻译
  作者：Azbazdar, Yagmur; De Robertis, Edward M.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：We recently reported that microinjection of Xenopus nodal- related (xnr) mRNAs into beta- catenin- depleted Xenopus embryos rescued a complete dorsal axis. Xnrs mediate the signal of the Nieuwkoop center that induces the Spemann-Mangold organizer in the overlying mesoderm, a process inhibited by the Nodal antagonist Cerberus-short (CerS). However, beta- catenin also induces a second signaling center in the dorsal prospective ectoderm, designated the Blastula Chordin and Noggin Expression (BCNE...