7期

最新文章

• Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis AI翻译
  作者：Ma, Lanjing; Pang, Zhongqiu; Zhang, Haijiao; Yang, Xueling; Zheng, Shaoqin; Chen, Yi; Ding, Weijie; Han, Qing; Zhang, Xi; Cao, Liu; Fei, Teng; Wang, Qiang; Gao, Daming; He, Aina; Hu, Ke-Bang; Li, Xuexin; Sheng, Ren
  作者单位：Northeastern University - China; NewYork-Presbyterian Hospital; Columbia University; Northeastern University - China; China Medical University; South China University of Technology; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Shanghai Jiao Tong University; Jilin University; China Medical University; China Medical University; China Medical University; Karolinska Institutet
  摘要：Clear cell renal cell carcinoma (ccRCC) is the predominant human renal cancer with surging incidence and fatality lately. Hyperactivation of hypoxia- inducible factor (HIF) and mammalian target of rapamycin (mTOR) signaling are the common signatures in ccRCC. Herein, we employed spontaneous ccRCC model to demonstrate the indispensability of an underappreciated Ser/Thr kinase, CDKL3, in the initiation and progression of ccRCC. Ablation of CDKL3 does not affect normal kidney, but abrogates Akt-m...
• Structural characterization of influenza group 1 chimeric hemagglutinins as broad vaccine immunogens AI翻译
  作者：Nguyen, Yen Thi Kim; Zhu, Xueyong; Han, Julianna; Rodriguez, Alesandra J.; Sun, Weina; Yu, Wenli; Palese, Peter; Krammer, Florian; Ward, Andrew B.; Wilson, Ian A.
  作者单位：Scripps Research Institute; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Medical University of Vienna; Scripps Research Institute
  摘要：Chimeric hemagglutinins (cHA) appear to be promising for the design and development of universal influenza vaccines. Influenza A group 1 cHAs, cH5/1, cH8/1, and cH11/1, comprising an H1 stem attached to either an H5, H8, or H11 globular head, have been used sequentially as vaccine immunogens in human clinical trials and induced high levels of broadly protective antibodies. Using X- ray crystallography and negative- stain electron microscopy, we determined structures of cH5/1, cH8/1, and cH11/1...
• Geometric modeling of knitted fabrics AI翻译
  作者：Niu, Lauren; Dion, Genevieve; Kamien, Randall D.
  作者单位：Drexel University; University of Pennsylvania
  摘要：It is undeniable that, by any metric, geometry plays a central role in our understanding of the physical world. From celestial mechanics (1) to soap bubbles (2) and from optics (3) to gravity (4), the rigor of geometric logic intoxicates our thinking. Indeed, because of their intrinsic elegance and potential application, tools have been developed to make materials that assemble into a targeted topography. Whether it be through the techniques of origami (5-7), thermal activation of local materi...
• Photopic flicker optoretinography captures the light- driven length modulation of photoreceptors during phototransduction AI翻译
  作者：Tomczewski, Slawomir; Curatolo, Andrea; Foik, Andrzej; Wegrzyn, Piotr; Balamut, Bartlomiej; Wielgo, Maciej; Kulesza, Wiktor; Galinska, Anna; Kordecka, Katarzyna; Gulati, Sahil; Fernandes, Humberto; Palczewski, Krzysztof; Wojtkowski, Maciej
  作者单位：Polish Academy of Sciences; Institute of Physical Chemistry of the Polish Academy of Sciences; Polytechnic University of Milan; University of Warsaw; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：In this study, we used an inhibitor of phosphodiesterase 6 (PDE6) to examine the impact of changes in the conformation of the PDE6 protein on the light- induced process responsible for altering the length of the outer segments of photoreceptor cells in both human and rodent eyes. We employed a imaging method called spatiotemporal optical coherence tomography, which ensures high contrast and phase stability within the strongly we recorded nanometer- scale changes in human cones and rods in resp...
• Debiasing job ads by replacing masculine language increases gender diversity of applicant pools AI翻译
  作者：He, Joyce C.; Kang, Sonia K.
  作者单位：University of California System; University of California Los Angeles; University of Toronto; University Toronto Mississauga
  摘要：Job advertisements for jobs in male- dominated fields tend to contain more masculine language, and a commonly proposed intervention to increase gender diversity in applicant pools is to remove this language. In our research, we offer predictions about the broader impact of such interventions on individuals who may not fit with traditional masculine identity. Across four multimethod studies (N = 37,920) spanning both field and lab settings, we demonstrate that a gender debiasing intervention th...
• Identification of FSH- regulated and estrous stage-specific transcriptional networks in mouse ovaries AI翻译
  作者：Walters, Kathryn; Baldwin, Amber; Liu, Zhenghui; Larsen, Mark; Mukherjee, Neelanjan; Kumar, T. Rajendra
  作者单位：University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus
  摘要：Follicle- stimulating hormone (FSH) acts by binding to FSHRs expressed on ovarian granulosa cells and produces estradiol. FSH is essential for female fertility because mice lacking FSH (Fshb KO) are anestrous and infertile. Although several in vitro cell culture and ex vivo approaches combined with pharmacological hormone treatment were used to identify FSH- regulated genes, how FSH orchestrates ovarian gene net-works in vivo has not been investigated. Whether FSH- regulated genes display estr...
• Receptor clustering tunes and sharpens the selectivity of multivalent binding AI翻译
  作者：Xie, Zhaoping; Angioletti-Uberti, Stefano; Dobnikar, Jure; Frenkel, Daan; Curk, Tine
  作者单位：Johns Hopkins University; Imperial College London; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Cambridge; Johns Hopkins University
  摘要：The immune system exploits a wide range of strategies to combine sensitivity with selectivity for optimal response. We propose a generic physical mechanism that allows tuning the location and steepness of the response threshold of cellular processes activated by multivalent binding. The mechanism is based on the possibility to modulate the attraction between membrane receptors. We use theory and simulations to show how tuning interreceptor attraction can enhance or suppress the binding of mult...
• Persistence selection between simulated biogeochemical cycle variants for their distinct effects on the Earth system AI翻译
  作者：Boyle, Richard A.; Moody, Edmund R. R.; Babcock, Gunnar; Mcshea, Daniel W.; alvarez-Carretero, Sandra; Lenton, Timothy M.; Donoghue, Philip C. J.
  作者单位：University of Exeter; University of Bristol; Cornell University; Duke University
  摘要：The average long- term impact of Darwinian evolution on Earth's habitability remains extremely uncertain. Recent attempts to reconcile this uncertainty by Darwinizing nonreplicating biogeochemical processes subject to persistence- based selection conform with the historicity of the geochemical record but lack mechanistic clarity.Here, we present a theoretical framework showing how: 1) A biogeochemical cycle- biota- variant (CBV) can be defined non- arbitrarily as one biologically facilitated p...
• Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel AI翻译
  作者：Loiodice, Melanie; Drula, Elodie; Mciver, Zak; Antonyuk, Svetlana; Basle, Arnaud; Lima, Marcelo; Yates, Edwin A.; Byrne, Dominic P.; Coughlan, Jamie; Leech, Andrew; Mesdaghi, Shahram; Rigden, Daniel J.; Drouillard, Sophie; Helbert, William; Henrissat, Bernard; Terrapon, Nicolas; Wright, Gareth S. A.; Couturier, Marie; Cartmell, Alan
  作者单位：Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; INRAE; Centre National de la Recherche Scientifique (CNRS); INRAE; University of York - UK; University of Liverpool; Newcastle University - UK; Keele University; University of York - UK; University of Liverpool; King Abdulaziz University; Technical University of Denmark; University of Essex; University of York - UK; University of York - UK
  摘要：Acidic glycans are essential for the biology of multicellular eukaryotes. To utilize them, microbial life including symbionts and pathogens has evolved polysaccharide lyases (PL) that cleave their 1,4 glycosidic linkages via a beta- elimination mechanism. PL family 33 (PL33) enzymes have the unusual ability to target a diverse range of glycosamino-glycans (GAGs), as well as the bacterial polymer, gellan gum. In order to gain more detailed insight into PL33 activities we recombinantly expressed...
• Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis AI翻译
  作者：Zhang, Xiaoyu; Liu, Yan; Wang, Ning
  作者单位：University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center
  摘要：Male germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed that lactate induces epigenetic modification in cells through histone lysine lactylation. Here, we report dynamic histone lactylation at histone H4- lysine 5 (K5),- K8, and- K12 during meiosis prophase I in mouse spermatogenesis. By profiling the genome-wide occupancy of histone H4- K8 lactylation...