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作者：Zhu, Chen; Dalsgaard, Bo; Li, Wande; Kaiser-Bunbury, Christopher N.; Simmons, Benno I.; Ren, Peng; Zhao, Yuhao; Zeng, Di; Goncalves, Fernando; Zhang, Xue; Chang, Longxiao; Ding, Ping; Si, Xingfeng
作者单位：Zhejiang University; University of Copenhagen; East China Normal University; University of Exeter; University of Zurich
摘要：Habitat fragmentation is causing the collapse of seed dispersal interactions and ecosystem functioning. When management and conservation strategies aim to sustain ecosystem functioning of fragmented forests, species' traits and functional performance are critical in guiding decisions. However, to date, we lack a quantitative understanding of the role of frugivores' body size and dispersal ability in ecosystem sustainability among fragmented forests. Focusing on avian frugivory and seed dispers...
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作者：Li, Liangzi; Scott, W. Shem; Khristich, Alexandra N.; Armenia, Jillian F.; Mirkin, Sergei M.
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作者：Tepekule, Burcu; Barcik, Weronika; Staiger, Willy I.; Bergada-Pijuan, Judith; Scheier, Thomas; Brulisauer, Laura; Hall, Alex R.; Gunthard, Huldrych F.; Hilty, Markus; Kouyos, Roger D.; Brugger, Silvio D.
作者单位：University of Zurich; University Zurich Hospital; University of Zurich; University Zurich Hospital; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Bern
摘要：Despite the rising challenge of antibiotic resistance, current approaches to eradicate nasal pathobionts Staphylococcus aureus and Streptococcus pneumoniae rely on antibac-terials. An alternative is the artificial inoculation of commensal bacteria, i.e., probiotic treatment, supported by the increasing evidence for commensal- mediated inhibition of pathogens. To systematically investigate the potential of this approach, we developed a quantitative framework simulating the nasal microbiome dyna...
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作者：Viegas, Jennifer
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作者：Brennecke, Benjamin; Civili, Beatrice; Sabale, Pramod M.; Barluenga, Sofia; Meyer, Benjamin; Winssinger, Nicolas
作者单位：University of Geneva; University of Geneva
摘要：Affinity proteins based on a three-helix bundle (affibodies, alphabodies, and computationally de novo designed ones) have been shown to be a general platform to discover binders with properties reminiscent of antibodies, combining high target specificity with affinities reaching well below the nanomolar. Herein, we report a strategy, coined self-assembled proteomimetic (SAP), to mimic such three-helix bundle architecture with a hybridization-enforced two-helix coiled coil that is obtained by t...
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作者：Wang, Zhihua; Cheng, Puxin; Han, Wenqing; Shi, Rongchao; Xu, Jian; Zheng, Yongshen; Xu, Jialiang; Bu, Xian-He
作者单位：Nankai University; Sinopec
摘要：Adaptive crystals have attracted significant attention from solid- state chemists and crystal engineers for their promising applications in memories, capacitors, sensors, and actuators. Among them, thermosalient crystals are particularly favored thanks to their efficient energy conversions and rapid responses. However, the mechanisms for the mechanical responses of thermosalient crystals remain largely unclear. Herein we demonstrate that thermosalient effects of molecular crystals could be dri...
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作者：Xu, Liang; Zhao, Xiao Hong; Zhang, Yuan Yuan; Zhang, Meng Yao; Zhang, Long Yue; Ye, Kai Hong; Teng, Liu; Han, Man Man; Yue, Yi Meng; Yang, Jiezhen; Ogle, Rachel; Netherton, Jacob; Tang, Deng; Lan, Siqi; Baker, Mark; Ye, Yan; Liu, Tao; Wang, Yu Fang; Zhang, Xu Dong; Fan, Tianli; Jin, Lei
作者单位：University of Newcastle; Zhengzhou University; Fudan University; Sichuan University; Anhui Medical University; University of New South Wales Sydney; Children's Cancer Institute; Children's Medical Research Institute - Australia; Zhengzhou University; University of Newcastle
摘要：The introns of the gene encoding the long noncoding RNA (lncRNA) GAS5 host up to 10 C/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between these snoRNAs and GAS5 is unknown. Here, we show that the expression of SNORD80, but not the other snoRNAs, parallels GAS5 expression and is regulated alongside GAS5 in response to cellular stress. The 2 '- O- methylation at the A496 site, located within a segment of GAS5 complementing the conserve...
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作者：Zhu, Haofang; Kong, Bin; Che, Junyi; Zhao, Yuanjin; Sun, Lingyun
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作者：Ikeda, Toma; Nojima, Tatsuya; Yamamoto, Souma; Yamada, Ryusei; Niwa, Tatsuya; Konno, Hiroki; Taguchi, Hideki
作者单位：Institute of Science Tokyo; Tokyo Institute of Technology; Institute of Science Tokyo; Tokyo Institute of Technology; Kanazawa University; Kanazawa University; Kanazawa University
摘要：According to classical Anfinsen's dogma, a protein folds into a single unique confor-mation with minimal Gibbs energy under physiological conditions. However, certain proteins may fold into two or more conformations from single amino acid sequences. Here, we designed a protein that adopts interconvertible alternative functional confor-mations, termed seesaw protein (SSP). An SSP was engineered by fusing GFP lacking the C- terminal beta- strand and dihydrofolate reductase (DHFR) lacking the N- ...
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作者：Proffitt, Tomos; Medeiros, Paula de Sousa; Martins, Waldney Pereira; Luncz, Lydia, V
作者单位：Max Planck Society; Universidade do Algarve; Universidade Estadual de Montes Claros; Universidade Estadual de Montes Claros
摘要：The evolution of stone tool technology marks a significant milestone in hominin devel-opment, enabling early humans to manipulate their environments. The oldest known evidence, dating to 3.3 Ma, indicates a combination of percussive and flake production activities. Studying the archaeological signature of percussive stone tool use in living primate provides a potential analog to the origin of stone flake technology in the hom-inin lineage. Here, we present a yellow- breasted capuchin (Sapajus ...
