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作者：Denk-Lobnig, Marlis K.; Wood, Kevin B.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Bacteria frequently inhabit surface- attached communities where rich social interac-tions can significantly alter their population- level behavior, including their response to antibiotics. Understanding these collective effects in spatially heterogeneous communi-ties is an ongoing challenge. Here, we investigated the spatial organization that emerges from antibiotic exposure in initially randomly distributed communities containing antibiotic- resistant and - sensitive strains of Enterococcus f...
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作者：Li, Jinan; Oh, Seung-Il; Liu, Chang; Zhao, Bo
作者单位：Indiana University System; Indiana University Bloomington
摘要：Aminoglycosides (AGs) are highly potent, broad- spectrum antibiotics frequently used as first- line treatments for multiple life- threatening infections. Despite their severe oto-toxicity, causing irreversible hearing loss in millions of people annually, no preventive therapy has been approved. We previously reported that GABARAP and several other central autophagy proteins are essential for AG- induced hearing loss. This finding opens avenues for the rational design and development of inhibit...
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作者：Heneghan, Padraic G.; Salzberg, Letal I.; Cinneide, Eoin o; Dewald, Jan A.; Weinberg, Christina E.; Wolfe, Kenneth H.
作者单位：University College Dublin; Leipzig University
摘要：Zymocin is a well- characterized killer toxin secreted by some strains of the yeast Kluyveromyces lactis. It acts by cleaving a specific tRNA in sensitive recipient cells. Zymocin is encoded by a killer plasmid or virus- like element (VLE), which is a linear DNA molecule located in the cytosol. We hypothesized that a tRNA- cleaving toxin similar to zymocin may have caused the three parallel changes to the nuclear genetic code that occurred during yeast evolution, in which the codon CUG became ...
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作者：Tan, Haohan; Zhao, Yuqian; Jin, Peng; Xu, Xiang; Zhou, Xinchen; Marchesoni, Fabio; Huang, Jiping
作者单位：Fudan University; Fudan University; Harbin Institute of Technology; Shanghai Jiao Tong University; Tongji University; University of Camerino
摘要：Enhancing thermoelectric conversion efficiency (TCE) is pivotal for advancing global energy conservation and emission reduction initiatives. Traditional approaches primarily focus on microscopic strategies such as bandgap engineering, chemical potential adjustments, and entropy engineering. However, these methods face substantial limitations in practical applications due to challenging material property requirements. Additionally, the efficiencies achieved remain modest, constrained by the int...
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作者：Dai, Yimei; Jiang, Yunyun; Cao, Canran; Xu, Yongtai; Lai, Siting; Zhu, Wenchao; Gao, Meng; Li, Feifei; He, Sicong; Xu, Jin
作者单位：South China University of Technology; South China University of Technology; South China University of Technology; South China University of Technology; South China University of Technology; Southern University of Science & Technology
摘要：Hemolysis induces tissue damage by releasing cellular contents into the plasma. It is widely accepted that hemolysis- derived toxic molecules are cleared by macrophages or metabolized in hepatocytes. In zebrafish, we found that scavenger endothelial cells (SECs), a specialized endothelium with remarkable endocytosis capability, engulf both macromolecular hemoglobin (Hb) and small molecular unconjugated bilirubin (UCB), two primary toxic byproducts of hemolysis. These engulfment processes are m...
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作者：Shikuma, Nicholas J.
作者单位：California State University System; San Diego State University; California State University System; San Diego State University
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作者：Joshy, Dennis; Santpere, Gabriel; Yi, Soojin V.
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作者：Schaeffer, Breanna M.; Truscott, Tadd T.; Dickerson, Andrew K.
作者单位：University of Tennessee System; University of Tennessee Knoxville; King Abdullah University of Science & Technology
摘要：Samaras are known for their elegant and robust autorotation, a resilience that persistsin the adverse conditions imposed by high-speed raindrops. Like flying insects, samarasdescending from tall trees are likely to be struck by raindrops in an intense storm. In thisstudy, we detail the collision dynamics for impact regions across the samara body andthe drop-shedding mechanisms that samaras exhibit to return to autorotation. Impactsacross the samara body can pitch the samara up to 60 degrees an...
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作者：He, Xing; Gupta, Mayanak K.; Abernathy, Douglas L.; Granroth, Garrett E.; Ye, Feng; Winn, Barry L.; Boatner, Lynn; Delaire, Olivier
作者单位：Duke University; Bhabha Atomic Research Center (BARC); United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Duke University; Duke University
摘要：Understanding the complex temporal and spatial correlations of ions in disordered perovskite oxides is critical to rationalize their functional properties. Here, we provide insights into the longstanding controversy regarding the off-centering of transition metal (TM) ions in the archetypal ferroelectric alloy KTa1-xNbxO3 (KTN). By mapping the full energy (E) and wavevector (Q) dependence of the dynamical structure factor S(Q, E) using neutron scattering, and rationalizing our observations wit...
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作者：Hasson, Michael; Marvin, M. Colin; Lapotre, Mathieu G. A.
