7期

最新文章

• Superfluid weight cross-over and critical temperature enhancement in singular flat bands AI翻译
  作者：Jiang, Guodong; Torma, Paivi; Barlas, Yafis
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; Aalto University
  摘要：Nonanalytic Bloch eigenstates at isolated band degeneracy points exhibit singular behavior in the quantum metric. Here, a description of superfluid weight for zero- energy flat bands in proximity to other high-energy bands is presented, where they together form a singular band gap system. When the singular band gap closes, the geometric and conventional contributions to the superfluid weight as a function of the superconducting gap exhibit different cross-over behaviors. The scaling behavior o...
• Downscaling mutualistic networks from species to individuals reveals consistent interaction niches and roles within plant populations AI翻译
  作者：Quintero, Elena; Arroyo-Correa, Blanca; Isla, Jorge; Rodriguez-Sanchez, Francisco; Jordano, Pedro
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); University of Sevilla
  摘要：Species- level networks emerge as the combination of interactions spanning multiple individuals, and their study has received considerable attention over the past 30 y. However, less is known about the structure of interaction configurations within species, even though individuals are the actual interacting units in nature. We compiled 46 empirical, individual- based, interaction networks on plant- animal seed dispersal mutualisms, comprising 1,037 plant individuals across 29 species from vari...
• Liver- specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes AI翻译
  作者：Rust, Lauren N.; Wettengel, Jochen M.; Ryu, Junghyun; Piekarski, Nadine; Yusova, Sofiya; Lutz, Savannah S.; Naldiga, Spandana; Hinrichs, Brayden J.; Sullivan, Michelle N.; Lo, Jamie O.; Protzer, Ulrike; V. Smedley, Jeremy; Sacha, Jonah B.; Hanna, Carol B.; Bimber, Benjamin N.; Hennebold, Jon D.; Burwitz, Benjamin J.
  作者单位：Oregon Health & Science University; Oregon National Primate Research Center; German Center for Infection Research; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University; Oregon National Primate Research Center
  摘要：Hepatitis B virus (HBV) poses a significant global health challenge, necessitating the urgent development of curative therapeutics. However, this progress is impeded by the lack of robust, immunocompetent preclinical animal models due to HBV's strict species specificity. We previously showed that vector- mediated expression of the HBV entry receptor, fully susceptible to HBV infection. In this study, we have generated transgenic macaques expressing hNTCP, marking the creation of the first tran...
• Reply to Chen et al.: Coarse simulations overestimate the distance to recover NO-NO2-O3 photochemical steady state in fresh NOx plumes AI翻译
  作者：Varon, Daniel J.; Jervis, Dylan; Pandey, Sudhanshu; Gallardo, Sebastian L.; Balasus, Nicholas; Yang, Laura Hyesung; Jacob, Daniel J.
  作者单位：Harvard University; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Comision Nacional de Energia Atomica (CNEA); Centro Atomico Bariloche
• 撤稿声明: DAT (deacylating autotransporter toxin) from Bordetella parapertussis demyristoylates Gαi GTPases and contributes to cough AI翻译
  作者：Hiramatsu, Yukihiro; Nishida, Takashi; Ota, Natsuko; Tamaki, Yuki; Nugraha, Dendi K.; Horiguchi, Yasuhiko
• The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms AI翻译
  作者：Kharrat, Ons; Yamaryo-Botte, Yoshiki; Nasreddine, Rouba; Voisin, Sebastien; Aumer, Thomas; Cammue, Bruno P. A.; Madinier, Jean-Baptiste; Knobloch, Thomas; Thevissen, Karin; Nehme, Reine; Aucagne, Vincent; Botte, Cyrille; Bulet, Philippe; Landon, Celine
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); Universite de Orleans; Bayer AG; KU Leuven
  摘要：Fungal infections represent a significant global health concern, with a growing prevalence of antifungal drug resistance. Targeting glucosylceramides (GlcCer), which are func-tionally important glycosphingolipids (GSL) present in fungal membranes, represents a promising strategy for the development of antifungal drugs. GlcCer are associated with the antifungal activity of certain plant and insect defensins. The 44- residue ETD151 peptide, optimized from butterfly defensins, is active against s...
• In the shadow of antibiotics AI翻译
  作者：Rasouly, Aviram; Nudler, Evgeny
  作者单位：New York University; Howard Hughes Medical Institute; New York University
• The MutRS quorum-sensing system controls lantibiotic mutacinproduction in the human pathogenStreptococcus mutans AI翻译
  作者：Wyllie, Ryan M.; Jensen, Paul A.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Microbes use quorum-sensing systems to respond to ecological and environmentalchanges. In the oral microbiome, the pathogenic bacteriumStreptococcus mutansusesquorum-sensing to control the production of bacteriocins. These antimicrobial peptideskill off ecological competitors and allowS. mutansto dominate the microenvironmentof dental plaques and form dental caries. One class of bacteriocins produced byS. mutans, the lantibiotic mutacins, are particularly effective at killing due to theirbroad...
• Fractional magnetic charges and channeling of Faraday lines by disclinations in artificial spin ice AI翻译
  作者：Hurben, Anthony; Hao, Yinchen; Chioar, Ioan- Augustin; Yang, Liu; Strandqvist, Nanny; Saccone, Michael; Bingham, Nicholas S.; Ramberger, Justin; Leighton, Chris; Nisoli, Cristiano; Schiffer, Peter
  作者单位：Yale University; Princeton University; United States Department of Energy (DOE); Los Alamos National Laboratory; United States Department of Energy (DOE); Los Alamos National Laboratory; University of Minnesota System; University of Minnesota Twin Cities
  摘要：We have studied the magnetic moments of artificial spin ice arrays of nanomagnets in both undistorted square arrays and in arrays with a topological defect induced by a single disclination. We confirm that the disclination induces global, macroscopic changes in the low- energy collective states of the nanomagnet moment configuration. Specifically, the disclination leads to Faraday lines of effective magnetic flux that run from the center all the way to the edge of the arrays. Moreover, the geo...
• Impairment of DET1 causes neurological defects and lethality in mice and humans AI翻译
  作者：Karayel, Ozge; Soung, Allison; Gurung, Hem; Schubert, Alexander F.; Klaeger, Susan; Kschonsak, Marc; Al-Maraghi, Aljazi; Bhat, Ajaz A.; Akil, ammira S. Alshabeeb; Dugger, Debra L.; Webster, Joshua D.; French, Dorothy M.; Anand, Dhullipala; Soni, Naharmal; Fakhro, Khalid A.; Rose, Christopher M.; Harris, Seth F.; Ndoja, Ada; Newton, Kim; Dixit, Vishva M.
  作者单位：Roche Holding; Genentech; Roche Holding USA; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Sidra Medical & Research Center; Roche Holding; Roche Holding USA; Genentech; Sidra Medical & Research Center; Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Qatar Foundation (QF); Weill Cornell Medical College Qatar
  摘要：COP1 and DET1 are components of an E3 ubiquitin ligase that is conserved from plants to humans. Mammalian COP1 binds to DET1 and is a substrate adaptor for the CUL4A-DDB1-RBX1 RING E3 ligase. Transcription factor substrates, including c-Jun, ETV4, and ETV5, are targeted for proteasomal degradation to effect rapid transcriptional changes in response to cues such as growth factor deprivation. Here, we link a homozygous DET1(R26W) mutation to lethal developmental abnormalities in humans. Experime...