8期

最新文章

• Mussel- inspired cross- linking mechanisms enhance gelation and adhesion of multifunctional mucin- derived hydrogels AI翻译
  作者：Degen, George D.; Stevens, Corey A.; Carcamo-Oyarce, Gerardo; Song, Jake; Bej, Raju; Tang, Peng; Ribbeck, Katharina; Haag, Rainer; Mckinley, Gareth H.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Free University of Berlin; Pontificia Universidad Catolica de Chile
  摘要：Mucus supports human health by hydrating, lubricating, and preventing infection of wet epithelial surfaces. The beneficial material properties and bioactivity of mucus stem from glycoproteins called mucins, motivating the development of mucin- derived hydro- gels for wound dressings and antifouling coatings. However, these applications require robust gelation and adhesion to a wide range of substrates. Inspired by the chemical cross- linking and water- tolerant adhesion of marine mussel adhesi...
• Viral circular RNA-encoded protein, ceVP28, divulges an antiviral response in invertebrates AI翻译
  作者：Limkul, Sirawich; Phiwthong, Tannatorn; Wanvimonsuk, Supitcha; Seabkongseng, Tuangrak; Aunkam, Phirom; Jaree, Phattarunda; Luangtrakul, Waruntorn; Mahanil, Kanjana; Teamtisong, Kamonluck; Tittabutr, Panlada; Teaumroong, Neung; Sarnow, Peter; Wang, Han-Ching; Somboonwiwat, Kunlaya; Boonchuen, Pakpoom
  作者单位：Suranaree University of Technology; Chulalongkorn University; Mahidol University; Suranaree University of Technology; Stanford University; National Cheng Kung University; National Cheng Kung University
  摘要：Invertebrates mostly use innate immunity to counteract pathogenic infections. In this study, shrimp was used as a model organism to explore the functions of circular RNAs (circRNAs) derived from white spot syndrome virus (WSSV). We identified four viral transcriptomic data of WSSV- infected shrimp. CircVP28, which contains an internal ribosome entry site, was further characterized to determine its potential as a template for protein translation. We observed the presence of a truncated, circRNA...
• Toward equitable major histocompatibility complex binding predictions AI翻译
  作者：Glynn, Eric; Ghersi, Dario; Singh, Mona
  作者单位：Princeton University; Princeton University; University of Nebraska System; University of Nebraska Omaha; Princeton University
  摘要：Deep learning tools that predict peptide binding by major histocompatibility complex (MHC) proteins play an essential role in developing personalized cancer immunotherapies and vaccines. In order to ensure equitable health outcomes from their application, MHC binding prediction methods must work well across the vast landscape of MHC alleles observed across human populations. Here, we show that there are alarming disparities across individuals in different racial and ethnic groups in how much b...
• Modeling energy requirements for oxygen production on AI翻译
  作者：Leger, Dorian; Ghaffari-Tabrizi, Fardin; Shaw, Matthew; Rasera, Joshua; Dickson, David; Valentin, Baptiste; Morlock, Anton; Thoresen, Freja; Cowley, Aidan
  作者单位：European Space Agency; European Astronaut Center; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Mineral Resources; Imperial College London; Colorado School of Mines; Helmholtz Association; Karlsruhe Institute of Technology
  摘要：Spacecraft using combustion engines require substantial amounts of oxygen for their propellant. The Moon could be a source of oxygen for rocket propellant, since the material composing the lunar surface can be processed to extract oxygen. However, little is known about overall energy requirements of the processes described in the literature for oxygen extraction from lunar regolith. This knowledge gap constrains the planning of lunar missions, since the scale of energy infrastructure required ...
• Adapting C4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in sorghum and sugarcane AI翻译
  作者：Salesse-Smith, Coralie E.; Adar, Noga; Kannan, Baskaran; Nguyen, Thaibinhduong; Wei, Wei; Guo, Ming; Ge, Zhengxiang; Altpeter, Fredy; Clemente, Tom E.; Long, Stephen P.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Nebraska System; University of Nebraska Lincoln; University of Nebraska System; University of Nebraska Lincoln; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Meta- analyses and theory show that with rising atmospheric [CO2], Rubisco has become the greatest limitation to light- saturated leaf CO2 assimilation rates (A(sat)) in C-4 crops. So would transgenically increasing Rubisco increase A(sat) and result in increased productivity in the field? Here, we successfully overexpressed the Rubisco small subunit (RbcS) with Rubisco accumulation factor 1 (Raft) in both sorghum and sugarcane, resulting in significant increases in Rubisco content of 13 to 25...
• A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism AI翻译
  作者：Elling, Felix J.; Pierrel, Fabien; Chobert, Sophie-Carole; Abby, Sophie S.; Evans, Thomas W.; Reveillard, Arthur; Pelosi, Ludovic; Schnoebelen, Juliette; Hemingway, Jordon D.; Boumendjel, Ahcene; Becker, Kevin W.; Blom, Pieter; Cordes, Julia; Nathan, Vinitra; Baymann, Frauke; Lucker, Sebastian; Spieck, Eva; Leadbetter, Jared R.; Hinrichs, Kai-Uwe; Summons, Roger E.; Pearson, Ann
  作者单位：Harvard University; University of Kiel; VetAgro Sup; Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Massachusetts Institute of Technology (MIT); University of Bremen; University of Bremen; Swiss Federal Institutes of Technology Domain; ETH Zurich; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Radboud University Nijmegen; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); University of Hamburg; California Institute of Technology; California Institute of Technology; Royal Dutch Shell; Boston University
  摘要：The dominant organisms in modern oxic ecosystems rely on respiratory quinones with high redox potential (HPQs) for electron transport in aerobic respiration and photosynthesis. The diversification of quinones, from low redox potential (LPQ) in anaerobes to HPQs in aerobes, is assumed to have followed Earth's surface oxygenation similar to 2.3 billion years ago. However, the evolutionary origins of HPQs remain unresolved. Here, we characterize the structure and biosynthetic pathway of an ancest...
• An acetyltransferase moonlights as a regulator of the RNA binding repertoire of the RNA chaperone Hfq in Escherichia coli (vol 120, e2311509120, 2024) AI翻译
  作者：Luo, Xing; Zhang, Aixia; Tai, Chin-Hsien; Chen, Jiandong; Majdalani, Nadim; Storz, Gisela; Gottesman, Susan
• Structural requirements of KAI2 ligands for activation of signal transduction AI翻译
  作者：Kushihara, Rito; Nakamura, Akihiko; Takegami, Katsuki; Seto, Yoshiya; Kato, Yusuke; Dohra, Hideo; Ohnishi, Toshiyuki; Todoroki, Yasushi; Takeuchi, Jun
  作者单位：Shizuoka University; Shizuoka University; Shizuoka University; National Institutes of Natural Sciences (NINS) - Japan; Institute for Molecular Science (IMS); Meiji University; Shizuoka University; Shizuoka University
  摘要：Karrikin Insensitive 2 (KAI2), identified as the receptor protein for karrikins (KARs), which are smoke- derived seed germination stimulants, belongs to the same alpha/beta- hydrolase family as D14, the receptor for strigolactones (SLs). KAI2 is believed to recognize an endogenous butenolide (KAI2 ligand; KL), but the identity of this compound remains unknown. Recent studies have suggested that ligand hydrolysis by KAI2 is a prerequisite for receptor activation to induce interaction with the t...
• Urban groundwater supplies facing dual pressures of depletion and contamination in China AI翻译
  作者：Sun, Siao; Liu, Hui; Konar, Megan; Fu, Guangtao; Fang, Chuanglin; Huang, Zhongwei; Li, Guagndong; Qi, Wei; Tang, Qiuhong
  作者单位：Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Illinois System; University of Illinois Urbana-Champaign; University of Exeter; Nanjing University of Information Science & Technology; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS
  摘要：Groundwater is essential to urban water supplies throughout the world, but we do not understand how quantity and quality issues may jeopardize the ability of cities to meet their water needs. Here, we present a national analysis of both quantity and quality challenges facing China's urban groundwater supply security, using high- resolution groundwater depletion modeling and a recently compiled dataset detailing quality violations in drinking groundwater sources. We estimate that 180 cities (ab...
• Fungal effector disables cathepsin-driven Toll immunity in insects AI翻译
  作者：Tay, Rebecca J.; Hsueh, Yen-Ping
  作者单位：Academia Sinica - Taiwan