8期

最新文章

• pH- dependent dissociation from CTLA-4 in early endosomes improves both safety and antitumor activity of anti- CTLA-4 antibodies AI翻译
  作者：Zhang, Meiyu; Li, Jinmei; Yan, Kepeng; Zhou, Haoyue; Mei, Song; Wang, Benyu; Li, Dongyang; Du, Xuexiang; Liu, Mingyue; Zhang, Peng; Fields, James K.; Ye, Lei; Zheng, Pan; Liu, Yang; Lenardo, Michael J.; Zhang, Yan
  作者单位：Chinese Academy of Sciences; Shanghai Jiao Tong University; University System of Maryland; University of Maryland Baltimore; Shandong University; Shandong University; Sichuan University; Capital Medical University; Johns Hopkins University; Johns Hopkins Medicine; Shanghai Jiao Tong University; Shanghai Jiao Tong University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Shanghai Jiao Tong University; Chinese Academy of Sciences
  摘要：Anti- CTLA- 4 Abs (ACAs) are a breakthrough for cancer therapy, but their potential is limited by immunotherapy- related adverse events (irAE). We previously reported that ACAs with acidic pH- sensitive binding to CTLA- 4 exhibit higher antitumor activity with fewer irAE. We now test a panel of variants of Ipilimumab (Ipi), the first ACA cancer therapeutic, for tumoricidal efficacy and irAE. Surprisingly, not all pH- sensitive Ipi variants exhibited an enhanced therapeutic index. Ipi13, which ...
• Learning-based inference of longitudinal image changes: Applications in embryo development, wound healing, and aging brain AI翻译
  作者：Kim, Heejong; Karaman, Batuhan K.; Zhao, Qingyu; Wang, Alan Q.; Sabuncu, Mert R.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Stanford University
  摘要：Longitudinal imaging data are routinely acquired for health studies and patient monitoring. A central goal in longitudinal studies is tracking relevant change time. Traditional methods remove nuisance variation with custom pipelines to focus on significant changes. In this work, we present a machine learning-based method that automatically ignores irrelevant changes and extracts the time-varying signal interest. Our method, called Learning-based Inference of Longitudinal imAge Changes (LILAC),...
• Planar device-enabled speckle illumination for dark- field label- free imaging beyond the diffraction limit AI翻译
  作者：Fan, Zetao; You, Xinxiang; Zhang, Douguo
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Dark- field microscopy is a technique used in optical microscopy to increase the contrast in unstained samples, making it possible to observe details that would otherwise be difficult to see under bright- field microscopy; thus, it has been widely employed in biological research, material science, and medical diagnostics. However, most dark- field microscopy methods cannot overcome the optical diffraction limit and require a bulky dark- field condenser and precise alignment of each optical ele...
• Explicitly unbiased large language models still form biased associations AI翻译
  作者：Bai, Xuechunzi; Wang, Angelina; Sucholutsky, Ilia; Griffiths, Thomas L.
  作者单位：University of Chicago; Stanford University; New York University; Princeton University; Princeton University
  摘要：Large language models (LLMs) can pass explicit social bias tests but still harbor implicit biases, similar to humans who endorse egalitarian beliefs yet exhibit subtle biases. Measuring such implicit biases can be a challenge: As LLMs become increasingly proprietary, it may not be possible to access their embeddings and apply existing bias measures; furthermore, implicit biases are primarily a concern if they affect the actual decisions that these systems make. We address both challenges by in...
• Experimental electronic structures of the FeIV=O bond in S=1 heme vs. nonheme sites: Effect of the porphyrin ligand AI翻译
  作者：Braun, Augustin; Gee, Leland B.; Waters, Max D. J.; Jose, Anex; Baker, Michael L.; Mara, Michael W.; Babicz, Jeffrey T., Jr.; Ehudin, Melanie A.; Quist, David A.; Zhou, Ang; Kroll, Thomas; Titus, Charles J.; Lee, Sang-Jun; Nordlund, Dennis; Sokaras, Dimosthenis; Yoda, Yoshitaka; Kobayashi, Yasuhiro; Tamasaku, Kenji; Hedman, Britt; Hodgson, Keith O.; Karlin, Kenneth D.; Que, Lawrence, Jr.; Solomon, Edward I.
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Johns Hopkins University; University of Minnesota System; University of Minnesota Twin Cities; Stanford University; Japan Synchrotron Radiation Research Institute; Kyoto University; RIKEN; University of Manchester; Diamond Light Source; United States Department of Energy (DOE); Argonne National Laboratory
  摘要：High-valent FeIV=O species are common intermediates in biological and artificial catalysts. Heme and nonheme S=1 FeIV=O sites have been synthesized and studied for decades but little quantitative experimental comparison of their electronic structures has been available, due to the lack of direct methods focused on the iron. This study allows a rigorous determination of the electronic structure of a nonheme FeIV=O center and its comparison to an FeIV=O heme site using 1s2p resonant inelastic X-...
• Editorial Expression of Concern for Duckworth et al., Role of test motivation in intelligence testing AI翻译
  作者：Duckworth, Angela Lee; Quinn, Patrick D.; Lynam, Donald R.
• STING- induced noncanonical autophagy regulates endolysosomal homeostasis AI翻译
  作者：Huang, Tuozhi; Sun, Chenglong; Du, Fenghe; Chen, Zhijian J.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center
  摘要：The cGAS-STING pathway mediates innate immune responses to cytosolic DNA. In addition to its well- established role in inducing inflammatory cytokines, activation of the cGAS-STING pathway also induces noncanonical autophagy, a process involving the conjugation of the ATG8 family of ubiquitin-like proteins to membranes of the endolysosomal system. The mechanisms and functions of STING- induced autophagy remain poorly understood. In this study, we demonstrated that STING activation induced form...
• A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER- positive breast cancer AI翻译
  作者：Yi, Jia; Du, Jiao; Chen, Xue; Nie, Rui-chao; Hu, Guo-sheng; Wang, Lei; Zhang, Yue-ying; Chen, Shang; Wen, Xiao-sha; Luo, Di-xian; He, Hua; Liu, Wen
  作者单位：Xiamen University; Xiamen University; Xiamen University; Jinfeng Laboratory; Xiamen University; Shenzhen University; Naval Medical University
  摘要：The molecular mechanisms underlying estrogen receptor (ER)- positive breast carcinogenesis and drug resistance remain incompletely understood. Elevated expression of CCND1 is linked to enhanced invasiveness, poorer prognosis, and resistance to drug therapies in ER- positive breast cancer. In this study, we identify a highly expressed circular RNA (circRNA) derived from FOXK2, called circFOXK2, which plays a key role in stabilizing CCND1 mRNA, thereby promoting cell cycle progression, cell grow...
• A size-dependent ideal solution model for liquid-solid phase equilibria prediction in aqueous organic solutions AI翻译
  作者：Alliston, Spencer P.; Dames, Chris; Powell-Palm, Matthew J.
  作者单位：University of California System; University of California Berkeley; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station
  摘要：Predictive synthesis of aqueous organic solutions with desired liquid-solid phase equilibria could drive progress in industrial chemistry, cryopreservation, and beyond, but is limited by the predictive power of current solution thermodynamics models. In particular, few analytical models enable accurate liquidus and eutectic prediction based only on bulk thermodynamic properties of the pure components, requiring instead either direct measurement or costly simulation of solution properties. this...
• Cryo- EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria AI翻译
  作者：Di Trani, Justin M.; Yu, Jiacheng; Courbon, Gautier M.; Rodriguez, Ana Paula Lobez; Cheung, Chen-Yi; Liang, Yingke; Coupland, Claire E.; Bueler, Stephanie A.; Cook, Gregory M.; Brzezinski, Peter; Rubinstein, John L.
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; Stockholm University; University of Otago; Queensland University of Technology (QUT); University of Alberta
  摘要：To investigate the structure of the mycobacterial oxidative phosphorylation machinery, we prepared inverted membrane vesicles from Mycobacterium smegmatis, enriched for vesicles containing complexes of interest, and imaged the vesicles with electron cryomicroscopy. We show that this analysis allows determination of the structure of both mycobacterial ATP synthase and the supercomplex of respiratory complexes III and IV in their native membrane. The latter structure reveals that the enzyme mala...