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作者：Lamb, Joleah B.; Abu, Nur; Limbong, Steven R.; Jompa, Jamaluddin; Feeney, William E.; Harvell, C. Drew
作者单位：University of California System; University of California Irvine; Universitas Muhammadiyah Sorong; Universitas Hasanuddin; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Cornell University
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作者：Vo, Lam; Avgidis, Fotios; Mattingly, Henry H.; Edmonds, Karah; Burger, Isabel; Balasubramanian, Ravi; Shimizu, Thomas S.; Kazmierczak, Barbara I.; Emonet, Thierry
作者单位：Yale University; Yale University; AMOLF; Simons Foundation; Flatiron Institute; Yale University; Yale University; Yale University
摘要：Cell populations must adjust their phenotypic composition to adapt to changing environments. One adaptation strategy is to maintain distinct phenotypic subsets within the population and to modulate their relative abundances via gene regulation. Another strategy involves genetic mutations, which can be augmented by stress- response pathways. Here, we studied how a migrating bacterial population regulates its phenotypic distribution to traverse diverse environments. We generated isogenic Escheri...
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作者：Adu, Oluwafemi F.; Lee, Hyunwook; Frueh, Simon P.; Schoenle, Marta, V; Weichert, Wendy S.; Flyak, Andrew I.; Hafenstein, Susan L.; Parrish, Colin R.
作者单位：Cornell University; University of Minnesota System; University of Munich; University of Minnesota System; University of Minnesota Twin Cities; Mayo Clinic
摘要：Host antibody responses are key components in the protection of animals against pathogens, yet the defining properties of viral antigens and induction of B cell responses that result in varied protection are still poorly understood. Parvoviruses are simple molecular structures that display 60 repeated motifs on their capsid surface, and rapidly induce strong antibody responses that protect animals from infection. We recently showed that following canine parvovirus infection of its natural host...
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作者：Huang, Delai; Kapadia, Emaan H.; Liang, Yipeng; Shriver, Leah P.; Dai, Shengkun; Patti, Gary J.; Humbel, Bruno M.; Laudet, Vincent; Parichy, David M.
作者单位：University of Virginia; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Okinawa Institute of Science & Technology Graduate University; Okinawa Institute of Science & Technology Graduate University; University of Virginia
摘要：The often- distinctive pigment patterns of vertebrates are varied in form and function and depend on several types of pigment cells derived from embryonic neural crest or latent stem cells of neural crest origin. These cells and the patterns they produce have been useful for uncovering features of differentiation and morphogenesis that underlie adult phenotypes, and they offer opportunities to discover how patterns and the cell types themselves have diversified. In zebrafish, a body pattern of...
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作者：Alhashim, Mohammed G.; Hausknecht, Kaylie; Brenner, Michael P.
作者单位：Harvard University; Saudi Aramco; Harvard University
摘要：Inverse design of complex flows is notoriously challenging because of the high cost of high dimensional optimization. Usually, optimization problems are either restricted to few control parameters, or adjoint-based approaches are used to convert the optimization problem into a boundary value problem. Here, we show that the recent advances in automatic differentiation (AD) provide a generic platform for solving inverse problems in complex fluids. To demonstrate the versatility of the approach, ...
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作者：Wu, Emily J.; Kandalkar, Ankita T.; Ehrmann, Julian F.; Tong, Alexander B.; Zhang, Jing; Cong, Qian; Wu, Hao
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Northeastern University; University of California System; University of California Berkeley; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：Death domain fold (DDF) superfamily proteins are critically important players in pathways of cell death and inflammation. DDFs are often essential scaffolding domains in receptors, adaptors, or effectors of these pathways by mediating homoand hetero- oligomerization including helical filament assembly. At the downstream ends of these pathways, effector oligomerization by DDFs brings the enzyme domains into proximity for their dimerization and activation. Hundreds of structures of these domains...
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作者：Borniego, M. Lucia; Singla-Rastogi, Meenu; Baldrich, Patricia; Sampangi-Ramaiah, Megha Hastantram; Karimi, Hana Zand; McGregor, Madison; Meyers, Blake C.; Innes, Roger W.
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作者：Gao, Haiyou; Wei, Xiumei; Li, Kang; Cao, Yi; Rao, Wenzhuo; Zhang, Jiansong; Wang, Ding; Yang, Jialong
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作者：Saks, Andrew J.; Barrie, Kyle R.; Rebowski, Grzegorz; Dominguez, Roberto
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：Arp2/3 complex generates branched actin networks essential for numerous motile functions of the cell. It comprises seven subunits: actin- related proteins (Arps) 2 and 3 and five scaffolding subunits (ArpC1-5). The complex adopts two major conformations: inactive, with the Arps interacting end- to- end, and active, with the Arps aligned side- by- side like subunits in the actin filament. Activation involves several cofactors, including ATP, WASP- family nucleation- promoting factors (NPFs), ac...
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作者：Stier, Christina; Balestrieri, Elio; Fehring, Jana; Focke, Niels K.; Wollbrink, Andreas; Dannlowski, Udo; Gross, Joachim
作者单位：University of Munster; University of Munster; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Munster
摘要：Understanding the evolving dynamics of the brain throughout life is pivotal for anticipating and evaluating individual health. While previous research has described age effects on spectral properties of neural signals, it remains unclear which ones are most indicative of age- related processes. This study addresses this gap by analyzing resting- state data obtained from magnetoencephalography (MEG) in 350 adults (18 to 88 y). We employed advanced time- series analysis at the brain region level...
