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作者：Rachuri, Swaksha; Nepal, Binod; Shukla, Anurag; Ramanathan, Aarti; Morrisey, Joanne M.; Daly, Thomas; Mather, Michael W.; Bergman, Lawrence W.; Kortagere, Sandhya; Vaidya, Akhil B.
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作者：Ziabari, Omid Saleh; Liu, Fangzhou; Deem, Kevin D.; Liu, Xiaomi; Kholwadwala, Akhil; Brisson, Jennifer A.
作者单位：University of Rochester; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Understanding how morphology evolves requires identifying the types of mutations that contribute to changes in development. We integrated comparative genomics and transcriptomics to reconstruct the evolution and regulation of follistatin paralogs in relation to the evolution of aphid winged and wingless morphs. We find that different pea aphid follistatin duplicates play an essential molecular role in both the male and female wing dimorphisms, linking the genetic and environmental control of m...
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作者：Zittlau, Katharina I.; Zachor-Movshovitz, Daniel; Leushkin, Yegor; Brener, Roy Schimmel; Morgenstern, David; Ben-Nissan, Gili; Sharon, Michal
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
摘要：The proteasome is a multisubunit degradation machinery that is essential for maintaining protein homeostasis by breaking down unnecessary or damaged proteins into peptides. While most of these peptides are further processed into amino acids, a subset evades complete degradation and plays key roles in biological processes such as antigen presentation, signaling, and apoptosis. However, the variability in peptide lengths and the diverse composition of proteasomes make their comprehensive identif...
